The advances in applying inorganic fluorescent nanomaterials for the detection of hepatocellular carcinoma and other cancers

Chen, Hetao; Shi, Dongxing; Wang, Yu; Zhang, Liwen; Zhang, Qiang; Wang, Baiqi; Xia, Chunhui

doi:10.1039/c5ra14853g

Cited by 10 publications

(1 citation statement)

References 101 publications

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“…Calipers assessed the tumor lengths (L) and widths (W), and the tumor volume by formula V = (L-W2)/2, where W is short of L, was determined. At the end of the experiment, mice were killed by CO 2 inhalation (Chen et al., 2015 ; 2015 ; Han et al., 2019 ; Li et al., 2020 ).…”

Section: Methodsmentioning

confidence: 99%

RETRACTED ARTICLE: A convergent synthetic platform for dual anticancer drugs functionalized by reduced graphene nanocomposite delivery for hepatocellular cancer

Zhang

Han

et al. 2021

Drug Delivery

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Hepatocellular carcinoma (HCC) is widespread cancer with a high degree of morbidity and mortality in individuals worldwide and a serious concern for its resistance to present chemotherapy drugs. In this investigation, the combination of cisplatin (CPT) and metformin (MET) to kill the HepG2 and caco-2 cells was developed into a new pH-responding magnetic nanocomposite based on reduced graphene oxide. Polyhydroxyethyl methacrylic (PHEA) was then linked employing grafting from approach to the reduced graphene oxide by ATRP polymerization (Fe 3 O 4 @rGO-G-PSEA). FT-IR, SEM, XRD, DLS, and TGA analyses evaluated physicochemical characteristics of the nanocomposite. In addition, the cellular uptake property of the nanocomposites was examined by the HepG2 cells. The outcomes of cell viability results indicate that the nanoparticles loaded with MET&CPT showed the lowest concentration rate of HepG2 and Caco-2 cells compared to the drug-loaded single nanocomposite groups and free drugs. The histological analysis has demonstrated relatively safe and does not produce different stress such as swelling and inflammation of the mice organs. Our results show the enhancement in cytotoxicity in HepG2 and Cocoa-2 cells by MET and CPT graphene oxide-based nanocomposite by promoting apoptotic response. Moreover, Fe 3 O 4 @rGO-G-PSEA showed potent in vivo antitumor efficacy but showed no adverse toxicity to normal tissues. Together, this study can provide insight into how surface embellishment may tune these nanocomposites' tumor specificity and provide the basis for developing anticancer efficacy.

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Section: Methodsmentioning

confidence: 99%

RETRACTED ARTICLE: A convergent synthetic platform for dual anticancer drugs functionalized by reduced graphene nanocomposite delivery for hepatocellular cancer

Zhang

Han

et al. 2021

Drug Delivery

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Functionalized fluorescent carbon nanostructures for targeted imaging of cancer cells: a review

et al. 2019

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Ratiometric electrochemical assay for sensitive detecting microRNA based on dual-amplification mechanism of duplex-specific nuclease and hybridization chain reaction

Yuan

Chi

Wen

et al. 2018

Biosensors and Bioelectronics

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The advances in applying inorganic fluorescent nanomaterials for the detection of hepatocellular carcinoma and other cancers

Abstract: The advances, drawbacks and application suggestions of QDs, UCNPs and CDs in HCC and other cancer detection fields are discussed.

Cited by 10 publications

References 101 publications

RETRACTED ARTICLE: A convergent synthetic platform for dual anticancer drugs functionalized by reduced graphene nanocomposite delivery for hepatocellular cancer

RETRACTED ARTICLE: A convergent synthetic platform for dual anticancer drugs functionalized by reduced graphene nanocomposite delivery for hepatocellular cancer

Functionalized fluorescent carbon nanostructures for targeted imaging of cancer cells: a review

Ratiometric electrochemical assay for sensitive detecting microRNA based on dual-amplification mechanism of duplex-specific nuclease and hybridization chain reaction

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