Primary proximal urethral adenocarcinoma: Case report and brief review

Siosaki, Marcos Duarte; Machado, Roberto Días; Souza, Ana Tarsila Fonseca; Magnabosco, Wesley Justino; Santos, Alexandre César; Gonçalves, Fernando Zapparoli; Pereira, Fernando Coutinho; Silva, Carlos Flávio de Araújo; Faria, Eliney Ferreira

doi:10.5489/cuaj.399

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Cited by 4 publications

(1 citation statement)

References 7 publications

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“…The commonest histological types in males are urothelial carcinoma (77.6%), squamous cell carcinoma (11.9%) and adenocarcinoma while in female's commonest histological types are squamous cell carcinoma (60%), followed by transitional cell carcinoma (20%), adenocarcinoma (10%), undifferentiated tumors (8%) and melanoma (2%) [9,10].…”

Section: Introductionmentioning

confidence: 99%

Challenges in Management of Primary Urethral Carcinoma: Case Series and Literature Review

Oj¹,

Ar²,

Js³

et al. 2021

COS

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Section: Introductionmentioning

confidence: 99%

Challenges in Management of Primary Urethral Carcinoma: Case Series and Literature Review

Oj¹,

Ar²,

Js³

et al. 2021

COS

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MRI of female urethra and periurethral pathologies

Davis¹,

Lalwani²,

Menias³

2023

Magnetic Resonance Imaging of the Pelvis

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A PAX-8-Positive Female Urethral Adenocarcinoma, Intestinal-Type: A Case Report with Diagnostic Challenges and a Review of the Literature

Torrez

Alba

Zhou

2023

Case Reports in Pathology

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Female urethral adenocarcinoma (FUA) is extremely rare. It is an aggressive malignancy, and clear cell and columnar/mucinous (“intestinal”) represent the two primary histologic subtypes. Diagnosis is often delayed in patients because of their vague symptomatology; hence, they present with an advanced disease and a poor prognosis. The rarity of FUA brings challenges when determining treatment and management, and treatment guidelines for various stages are lacking. We report an intestinal-type FUA that developed from inflammation-related metaplasia in urethral diverticulum with positive paired box 8 (PAX-8) staining. In addition to intestinal-type FUA being extremely rare, this particular entity exhibiting PAX-8 positivity has not been previously described, to the author’s best knowledge. The present report highlights the importance of clinical and radiological assessment as well as histomorphologic and immunophenotypic features for an accurate diagnosis of this rare and aggressive malignancy.

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Primary proximal urethral adenocarcinoma: Case report and brief review

Cited by 4 publications

References 7 publications

Challenges in Management of Primary Urethral Carcinoma: Case Series and Literature Review

Challenges in Management of Primary Urethral Carcinoma: Case Series and Literature Review

MRI of female urethra and periurethral pathologies

A PAX-8-Positive Female Urethral Adenocarcinoma, Intestinal-Type: A Case Report with Diagnostic Challenges and a Review of the Literature

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