Sexual behavior and dendritic spine density of posterodorsal medial amygdala neurons in oxytocin knockout female mice

Becker, Ralf; Lazzari, Virgínia; Menezes, Itiana Castro; Morris, Mariana; Rigatto, Katya; Lucion, Aldo Bolten; Rasia‐Filho, Alberto A.; Giovenardi, Márcia

doi:10.1016/j.bbr.2013.07.034

Cited by 21 publications

(12 citation statements)

References 78 publications

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“…However, it cannot be ruled out that other nNOS neuron populations are also involved, for instance, in the rostral preoptic area, where nNOS neurons are part of a neural circuitry mediating ovarian cyclicity and ovulation 54 , and in the paraventricular nucleus (PVN), where nNOS co-localizes with oxytocin. The latter has also been implicated in sexual behavior in female rodents: mating activates PVN oxytocin neurons and increases local oxytocin concentrations, in particular following a pace mating paradigm in which the female controls the mating, thereby linking oxytocin in particular with sexual motivation 55 , 56 . Therefore, further experiments are needed to dissect the precise role of the different nNOS populations in the brain in controlling reproductive behaviors.…”

Section: Discussionmentioning

confidence: 99%

Female sexual behavior in mice is controlled by kisspeptin neurons

et al. 2018

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Sexual behavior is essential for the survival of many species. In female rodents, mate preference and copulatory behavior depend on pheromones and are synchronized with ovulation to ensure reproductive success. The neural circuits driving this orchestration in the brain have, however, remained elusive. Here, we demonstrate that neurons controlling ovulation in the mammalian brain are at the core of a branching neural circuit governing both mate preference and copulatory behavior. We show that male odors detected in the vomeronasal organ activate kisspeptin neurons in female mice. Classical kisspeptin/Kiss1R signaling subsequently triggers olfactory-driven mate preference. In contrast, copulatory behavior is elicited by kisspeptin neurons in a parallel circuit independent of Kiss1R involving nitric oxide signaling. Consistent with this, we find that kisspeptin neurons impinge onto nitric oxide-synthesizing neurons in the ventromedial hypothalamus. Our data establish kisspeptin neurons as a central regulatory hub orchestrating sexual behavior in the female mouse brain.

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Section: Discussionmentioning

confidence: 99%

Female sexual behavior in mice is controlled by kisspeptin neurons

et al. 2018

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“…OTKO males showed reduced social behaviors, but no change in sexual activity [93]. OTKO females displayed a reduction in sexual receptiveness and ovulation [94, 95]. OTKO females showed reduced OT receptors and AVP receptors (AVPR) in the hippocampus.…”

Section: Perinatal Environmental Interventions Have Long-term Consequmentioning

confidence: 99%

Factors promoting vulnerability to dysregulated stress reactivity and stress‐related disease

Russell

Tasker²,

Lucion

et al. 2018

J Neuroendocrinology

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Effective coordination of the biological stress response is integral for the behavioural well-being of an organism. Stress reactivity is coordinated by an interplay of the neuroendocrine system and the sympathetic nervous system. The hypothalamic-pituitary-adrenal (HPA) axis plays a key role in orchestrating the bodily responses to stress, and the activity of the axis can be modified by a wide range of experiential events. This review focuses on several factors that influence subsequent HPA axis reactivity. Some of these factors include early-life adversity, exposure to chronic stress, immune activation and traumatic brain injury. The central premise is that each of these experiences serves as a general vulnerability factor that accelerates future HPA axis reactivity in ways that make individuals more sensitive to stress challenges, therefore feeding forward into the exacerbation of ongoing (or greater susceptibility toward) future stress-related disease states, especially as they pertain to negative affect and overall brain health.

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“…These combined functions, as well as amygdala plasticity (Becker et al 2013), may be altered by the action of neuropeptides (Chung and Moore 2007, 2009; Debiec 2005; Knobloch et al 2012; Kritman et al 2017; Quagliotto et al 2015). …”

Section: Introductionmentioning

confidence: 99%

“…The amygdaloid complex is formed by nuclei with heterogeneous anatomical and functional characteristics (de Olmos et al 2004 ; Rasia-Filho et al 2000 ), integrating endocrine, sympathetic/parasympathetic, behavioral activities, emotion processing, facial expression recognition and feeding behavior (Janak and Tye 2015 ; Quagliotto et al 2015 ). These combined functions, as well as amygdala plasticity (Becker et al 2013 ), may be altered by the action of neuropeptides (Chung and Moore 2007 , 2009 ; Debiec 2005 ; Knobloch et al 2012 ; Kritman et al 2017 ; Quagliotto et al 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Effect of long-term treatment with classical neuroleptics on NPQ/spexin, kisspeptin and POMC mRNA expression in the male rat amygdala

et al. 2018

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Neuroleptics modulate the expression level of some regulatory neuropeptides in the brain. However, if these therapeutics influence the peptidergic circuits in the amygdala remains unclear. This study specifies the impact profile of the classical antipsychotic drugs on mRNA expression of the spexin/NPQ, kisspeptin-1 and POMC in the rat amygdala. Animals were treated with haloperidol and chlorpromazine for 28 days prior to transcript quantification via qPCR. Haloperidol and chlorpromazine induced a change in the expression of all neuropeptides analyzed. Both drugs led to the decrease of Kiss-1 expression, whereas in POMC and spexin/NPQ their up-regulation in the amygdala was detected. These modulating effects on may represent alternative, so far unknown mechanisms, of classical antipsychotic drugs triggering pharmacological responses.

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Sexual behavior and dendritic spine density of posterodorsal medial amygdala neurons in oxytocin knockout female mice

Cited by 21 publications

References 78 publications

Female sexual behavior in mice is controlled by kisspeptin neurons

Female sexual behavior in mice is controlled by kisspeptin neurons

Factors promoting vulnerability to dysregulated stress reactivity and stress‐related disease

Effect of long-term treatment with classical neuroleptics on NPQ/spexin, kisspeptin and POMC mRNA expression in the male rat amygdala

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