Gingival Overgrowth in Renal Transplant Subjects

Costa, Lidiane Cristina Machado; Costa, Fernando Oliveira; Cortelli, Sheila Cavalca; Cortelli, José Roberto; Cota, Luís Otávio Miranda

doi:10.1097/tp.0b013e3182a1cd0c

Cited by 8 publications

(3 citation statements)

References 29 publications

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“…11–20 Common AEs were hyperlipidemia; comparator-adjusted frequency, 21% 21 ; hypertension, 26% 22 ; cardiac events, 19% 23 ; gingival hyperplasia, 13–43% 24,25 ; and increased creatinine, 12%. 26 The incidence of AEs was not consistently shown to be dose related, and observed drug concentrations among those with certain AEs were often similar to those in patients without these events.…”

Section: Resultsmentioning

confidence: 99%

A Systematic Literature Review Approach to Estimate the Therapeutic Index of Selected Immunosuppressant Drugs After Renal Transplantation

Ericson

Zimmerman

González

et al. 2017

Therapeutic Drug Monitoring

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Background Drugs that exhibit close margins between therapeutic and toxic blood concentrations are considered to have a narrow therapeutic index (NTI). The Food and Drug Administration has proposed that NTI drugs should have more stringent bioequivalence standards for approval of generic formulations. However, many immunosuppressant drugs do not have a well-defined therapeutic index (TI). Methods We sought to determine whether safety, efficacy, and pharmacokinetic data obtained from the medical literature through a comprehensive literature search could be used to estimate the TI of cyclosporine, tacrolimus, and sirolimus. In this analysis, we considered TI ≤2 as a criterion to define a drug as having an NTI. Results Published literature indicates that cyclosporine has a TI of 2–3, which falls just short of our criteria to be classified as having an NTI. We found sirolimus and tacrolimus to have a therapeutic range of 5–12 ng/mL and of 5–20 ng/mL, respectively, but were unable to calculate the TI. Conclusion Although current literature does not provide a clear indication that these drugs have an NTI, the routine use of therapeutic drug monitoring in clinical practice suggests that more stringent testing of their pharmacokinetic and pharmacodynamic properties should be performed prior to the approval of generic formulations.

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Section: Resultsmentioning

confidence: 99%

A Systematic Literature Review Approach to Estimate the Therapeutic Index of Selected Immunosuppressant Drugs After Renal Transplantation

Ericson

Zimmerman

González

et al. 2017

Therapeutic Drug Monitoring

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show abstract

“…As a potent immunosuppressant, cyclosporin A (CsA) has been used for the prevention of transplant rejection or treatment of rheumatoid arthritis. Around 50% of adult transplant patients may encounter CsA-associated gingival enlargement [ 85 , 86 ]. It was suggested that administration of CsA may induce EMT in gingival epithelium [ 62 ], and the upregulation of the EMT inducer Slug was observed in HGFs [ 64 ].…”

Section: Gingival Overgrowthmentioning

confidence: 99%

Emerging Role of MicroRNA-200 Family in Dentistry

Hsieh

Huang

2021

ncRNA

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MicroRNAs (miRNAs) are endogenous non-coding RNAs ~22 nucleotides in length, which have been shown to participate in various biological processes. As one of the most researched miRNAs, the miR-200 family has been found to regulate several factors that are associated with the epithelial to mesenchymal transition (EMT) and cancer stem cells (CSCs) behavior. In this review, we briefly summarize the background of the miR-200 family and their implication in various dental diseases. We focus on the expression changes, biological functions, and clinical significance of the miR-200 family in oral cancer; periodontitis; oral potentially malignant disorder; gingival overgrowth; and other periodontal diseases. Additionally, we discuss the use of the miR-200 family as molecular biomarkers for diagnosis, prognostic, and therapeutic application.

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“…Some immunosuppressants such as cyclosporine A and, according to some authors, tacrolimus are also associated with gingival enlargement. 53 , 139 Proper periodontal maintenance is necessary to avoid the appearance of gingival enlargement. Despite proper periodontal control, gingival enlargement may appear around the implants.…”

Section: Dental Implant Treatmentmentioning

confidence: 99%

Dental implant treatment for renal failure patients on dialysis: a clinical guideline

et al. 2017

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Chronic kidney disease (CKD) is a worldwide public health problem that is growing in prevalence and is associated with severe complications. During the progression of the disease, a majority of CKD patients suffer oral complications. Dental implants are currently the most reliable and successful treatment for missing teeth. However, due to complications of CKD such as infections, bone lesions, bleeding risks, and altered drug metabolism, dental implant treatment for renal failure patients on dialysis is more challenging. In this review, we have summarized the characteristics of CKD and previous publications regarding dental treatments for renal failure patients. In addition, we discuss our recent research results and clinical experience in order to provide dental implant practitioners with a clinical guideline for dental implant treatment for renal failure patients undergoing hemodialysis.

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Gingival Overgrowth in Renal Transplant Subjects

Abstract: There was no incidence of GO, and a decrease in the occurrence and severity of GO was significant in total sample. This decrease can be attributed to changes in pharmacologic and periodontal variables over this period of time.

Cited by 8 publications

References 29 publications

A Systematic Literature Review Approach to Estimate the Therapeutic Index of Selected Immunosuppressant Drugs After Renal Transplantation

A Systematic Literature Review Approach to Estimate the Therapeutic Index of Selected Immunosuppressant Drugs After Renal Transplantation

Emerging Role of MicroRNA-200 Family in Dentistry

Dental implant treatment for renal failure patients on dialysis: a clinical guideline

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