Thigh Circumference and Diabetes: Obesity as a Potential Effect Modifier

Abstract

BackgroundThigh circumference is associated with diabetes risk; however, the role of obesity as a potential effect modifier has not been well studied.MethodsWe examined the association between thigh circumference and diabetes in a cross-sectional study of 384 612 Koreans aged 30 to 79 years. The association between diabetes and thigh circumference in relation to body mass index (BMI) was analyzed among 315 628 participants, using multivariate logistic regression. Thigh circumference was categorized into 9 percentile categories—namely, the 2.5th, 5th, 10th, 25th, 50th, 75th, 90th, 95th, and 97.5th percentiles—and the 50th percentile was used as the reference value for thigh circumference. Separate analyses were performed for men and women.ResultsThe association of thigh circumference with diabetes showed contradictory patterns before and after adjustment for BMI and waist circumference. Small thigh circumference was associated with greater risk of diabetes among men and women. This relationship was stronger among participants younger than 50 years, although age was not a significant effect modifier. BMI was a significant effect modifier among men with a BMI of less than 25 kg/m2. Among women, diabetes risk increased with smaller thigh circumference.ConclusionsSmall thigh circumference was associated with diabetes, and this association was stronger among participants with a BMI of less than 25 kg/m2. Thigh circumference might be a useful diabetes marker in lean populations.

Relationship between Dietary Protein or Essential Amino Acid Intake and Training-Induced Muscle Hypertrophy among Older Individuals

“…Furthermore, recent cohort studies have shown that reduced muscle mass alone is associated with an increased risk of diabetes, cardiovascular disease (3,4), and higher mortality (5) among older individuals, highlighting the importance of skeletal muscle to the modulation of metabolism.…”

Examining the association between vestibular function and lower extremity circumference in an aged population

“…In a large cross-sectional study of 384 612 Koreans aged 30-79 years, Jung et al showed that small TC might be a useful diabetes marker in lean populations. 25 Another population-based cohort study also summarized that large TC was connected with a lower risk of developing diabetes, independent of age, WC and body mass index. 26 Furthermore, Li et al claimed that WTR had a strong association with diabetes from the data of NHANES III.…”

“…Furthermore, several studies have discussed the relationship between lower extremity circumferences, diabetes and diabetes‐related complications. In a large cross‐sectional study of 384 612 Koreans aged 30–79 years, Jung et al showed that small TC might be a useful diabetes marker in lean populations . Another population‐based cohort study also summarized that large TC was connected with a lower risk of developing diabetes, independent of age, WC and body mass index .…”

A relação pescoço-coxa (RPCx) pode servir como índice antropométrico para diagnosticar a síndrome metabólica?

“…Studies have shown that, individually, the estimates drawn by NC and TC are capable of indicating risks for the development of chronic diseases, being better than other known anthropometric measures, such as body mass index (BMI). (7)(8)(9)(10)(11)(12) Similarly, research has also emphasized the use of obesity indicators, such as waist-hip ratio and waist-to-height ratio (WHR), in determining cardiovascular and metabolic adverse conditions. (13)(14)(15)(16) However, even with significant results regarding the predictive capacity of the NC and TC estimates, there are no data demonstrating the neck-thigh ra-tio (NTR) as an anthropometric index to measure the role of chronic diseases that condition MS.…”