Is calcium signaling relevant for long bone growth?

Marcucci, Gemma; Masi, Laura; Cavalli, Loredana; Fossi, Caterina; Franceschelli, Francesco; Brandi, Maria Luisa

doi:10.1016/j.bone.2013.07.008

Cited by 3 publications

(2 citation statements)

References 41 publications

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“…However, there is only one published report describing long‐term follow‐up data in an affected subject. The patient, who required an early parathyroidectomy for survival, exhibited a statural defect as represented by an increased ratio of the upper and the lower segments, but bone tissue was not examined …”

Section: Discussionmentioning

confidence: 99%

“…The patient, who required an early parathyroidectomy for survival, exhibited a statural defect as represented by an increased ratio of the upper and the lower segments, but bone tissue was not examined. (24) Investigation of the potential role of the CaSR in the bone has been the focus of multiple experimental in vitro and in vivo studies. Most in vitro studies have observed that calcium promotes differentiation, proliferation, and mineralized of osteoblastic "nodule" formation in a dose-dependent manner.…”

Section: Discussionmentioning

confidence: 99%

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Bone Matrix Mineralization in Patients With Gain-of-Function Calcium-Sensing Receptor Mutations Is Distinctly Different From that in Postsurgical Hypoparathyroidism

Ovejero

Misof

Gafni

et al. 2018

Journal of Bone and Mineral Research

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The role of the calcium‐sensing receptor (CaSR) as a regulator of parathyroid hormone secretion is well established, but its function in bone is less well defined. In an effort to elucidate the CaSR's skeletal role, bone tissue and material characteristics from patients with autosomal dominant hypocalcemia (ADH), a genetic form of primary hypoparathyroidism caused by CASR gain‐of‐function mutations, were compared to patients with postsurgical hypoparathyroidism (PSH). Bone structure and formation/resorption indices and mineralization density distribution (BMDD), were examined in transiliac biopsy samples from PSH (n = 13) and ADH (n = 6) patients by histomorphometry and quantitative backscatter electron imaging, respectively. Bone mineral density (BMD by DXA) and biochemical characteristics were measured at the time of the biopsy. Because both study groups comprised children and adults, all measured biopsy parameters and BMD outcomes were converted to Z‐scores for comparison. Histomorphometric indices were normal and not different between ADH and PSH, with the exception of mineral apposition rate Z‐score, which was higher in the ADH group. Similarly, average BMD Z‐scores were normal and not different between ADH and PSH. Significant differences were observed for the BMDD: average Z‐scores of mean and typical degree of mineralization (CaMean, CaPeak, respectively) were lower (p = 0.02 and p = 0.03, respectively), whereas the heterogeneity of mineralization (CaWidth) and percentage of lower mineralized areas (CaLow) were increased in ADH versus PSH (p = 0.01 and p = 0.002, respectively). The BMDD outcomes point toward a direct, PTH‐independent role of the CaSR in the regulation of bone mineralization. © 2018 American Society for Bone and Mineral Research.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Bone Matrix Mineralization in Patients With Gain-of-Function Calcium-Sensing Receptor Mutations Is Distinctly Different From that in Postsurgical Hypoparathyroidism

Ovejero

Misof

Gafni

et al. 2018

Journal of Bone and Mineral Research

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Parathyroid hormone

2013

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Progressive Impairment of Prepubertal Growth in Children With APECED

Saari,

Alanko,

Holopainen

et al. 2024

The Journal of Clinical Endocrinology &Amp; Metabolism

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Context Subjects with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) have subnormal adult height. There are several potential APECED-related risk factors for suboptimal height attainment during childhood. Objective To determine the growth patterns in children with APECED Design Retrospective longitudinal study Setting The Finnish national APECED cohort Patients 59 children with APECED Main Outcome Measures Length/height and weight z-scores from birth to the end of prepuberty Results Collectively, 59 children [30 (51%) girls] were included. Their median birth weight z-score (-0.60) was below the population average; 12 (20%) patients were born small for gestational age. Height attainment progressively declined from birth until the end of prepuberty (z-score -1.95), whereas weight-for-height z-score did not (+0.26). Of the 59 patients, 38 (64%) had all height z-scores below 0 during prepuberty, and seven (12%) had z-scores below -2.0. Age at the end of prepuberty, number of APECED manifestations, duration of glucocorticoid treatment, and growth hormone deficiency correlated negatively with height z-score at the end of prepuberty (p < 0.0001; p = 0.041; p = 0.013; p = 0.034, respectively). Conclusions Children with APECED had a progressive growth impairment from birth through prepuberty. Multiple predisposing risk factors were recognized, including disease severity and growth hormone deficiency. Timely interventions are needed to ensure optimal height attainment and new treatment options need to be developed.

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Is calcium signaling relevant for long bone growth?

Cited by 3 publications

References 41 publications

Bone Matrix Mineralization in Patients With Gain-of-Function Calcium-Sensing Receptor Mutations Is Distinctly Different From that in Postsurgical Hypoparathyroidism

Bone Matrix Mineralization in Patients With Gain-of-Function Calcium-Sensing Receptor Mutations Is Distinctly Different From that in Postsurgical Hypoparathyroidism

Parathyroid hormone

Progressive Impairment of Prepubertal Growth in Children With APECED

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