Traumeel vs. diclofenac for reducing pain and improving ankle mobility after acute ankle sprain: A multicentre, randomised, blinded, controlled and non‐inferiority trial

Abstract

BackgroundAcute ankle sprains are common and activity limiting injuries, and topical diclofenac gel has proven efficacy in alleviating pain and restoring function. This trial aimed to compare a topical natural agent, Traumeel with topical diclofenac gel (1%) in the management of acute ankle sprain.MethodsThis prospective, multicentre, randomised, blinded, active-control and non-inferiority study involved 449 physically active adults sustaining unilateral grade 1 or 2 ankle sprain within the past 24 h. Participants were randomised to receive 2 g of Traumeel ointment (T-O) (n = 152) or Traumeel gel (T-G) (n = 150) or diclofenac gel (D-G) (n = 147), administered topically to the ankle three times a day for 14 days, with 6-weeks follow up.ResultsDay 7 median percentage reductions in Visual Analogue Scale pain score were 60.6%, 71.1% and 68.9% for the T-O, T-G and D-G groups, respectively. Total pain relief was reported by 12 (8.5%), 7 (5.0%) and 8 (5.9%) participants in each group, respectively. Median improvements in Foot and Ankle Ability Measure Activities of Daily Living subscale score were 26.2, 26.2 and 25.0 points for T-O, T-G and D-G groups, respectively. Mann–Whitney effect sizes and lower bound confidence intervals demonstrated non-inferiority of Traumeel vs. diclofenac for reducing pain and functional improvement. At 6 weeks, participants reported total pain relief and normal functioning. Adverse events (n = 43) were reported by 31/447 participants (6.9%). Treatments were equally well tolerated.ConclusionsT-O and T-G decreased pain and improved joint function to the same extent as D-G in acute ankle sprain, and were well tolerated.

The Risk Factors for Ankle Sprain in Cadets at a Male Military School in Iran: A Retrospective Case-control Study

“…It is believed that the inversion mechanisms are responsible for 85% to 90% of ankle sprains [2]. As for activity practiced by the cadet when he had the injury, the most ankle sprains (56.25%) occurred in training, compared with only 37.5% in matches.…”

“…Many researchers have identi ied the ankle sprain responsible for 15% to 45% of whole injuries in contact and noncontact sports and also responsible for 75% of ankle injuries and inversion mechanisms cause 85% to 90% of these injuries [1,2].…”

“…Hand dominance, age, body mass index (BMI), skill level, and shoe type have been identi ied as the main risk factors [18][19][20][21][22][23][24]. Differences in the measurement techniques, dissimilar baseline risks associated with different sports, disparities in statistical analyses, the differences in methods of data collection and differences in de initions of injury and severity caused the lack of consensus [2]. There was little evidence about the risk factors of ankle sprain in uniformed groups in the literature [8].…”

Efficacy of Local Nsaids Therapy With Osteoarthritis Different Localization

“…(2013) [28] проведено сравнение эффективности 2 препаратов по влиянию на интенсивность боли и улучше-ние подвижности лодыжки при растяжении связок: гомео-патическое обезболивающее средство в форме мази (n = 152) или геля (n = 150) и диклофенак гель 1%-ный (n = 147). В исследовании приняли участие 449 физически активных лиц с растяжением связок лодыжки 1-2 ст.…”

“…Уже на 7-й день во всех группах отмечено уменьшение выраженности болевого синдрома: в группе диклофенак-гель 1%-ный -в 68,9% случаев, улучшение в тесте «Оценка повседневной активности и функционального состояния стопы и лодыжки» в группе диклофенак-гель 1%-ный -на 25 пунктов. В исследовании продемонстрирована эффек-тивность геля диклофенак 1%-ный на 7-й день от начала терапии в отношении интенсивности болевого синдрома после перенесенной травмы стопы [28].…”