Exercise after diagnosis and metabolic syndrome among breast cancer survivors: a report from the Shanghai Breast Cancer Survival Study

Bao, Ping‐Ping; Zheng, Ying; Nechuta, Sarah; Gu, Kai; Cai, Hui; Peng, Peng; Lü, Wei

doi:10.1007/s10552-013-0252-7

Cited by 27 publications

(21 citation statements)

References 41 publications

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“…Holmes et al demonstrated a reduction in the risk of death due to breast cancer in women who exercised (3-5 hours per week) after treatment compared to women with a sedentary lifestyle (18). Other research groups have confirmed these results (19)(20)(21)(22). Walsh et al and Daroux-Cole et al suggested that exercise stimulated the immune system in cancer patients (23,24).…”

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confidence: 77%

The Impact of Exercise Training on Breast Cancer

Siewierska

Malicka

Kobierzycki

et al. 2018

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Abstract. Background Breast cancer is still a major medical, social and economic problem due to the increasing prevalence and unsatisfactory treatment results. In 2013, nearly 235,000 new cases of breast cancer were reported in the United States, which accounted for 29% of all malignant neoplasms and was related to 14% risk of death. Based on current trends, over 23 million of new cases will be diagnosed by the year 2030 (1).Numerous scientific reports indicate the impact of physical activity on the development of breast cancer. However, the results are not conclusive (2-9). Westerlind et al. found that in girls aged 10-15 who were more active than their peers with a sedentary lifestyle the risk for developing breast cancer decreased by 30-50% (2). Studies on animal models also confirm this thesis. Malicka et al. demonstrated that moderate intensity training reduced the number of induced tumors in rats (4). Other studies showed that in animals physically active at puberty (rodent treadmill, tunnels and ladders), the risk of developing the disease is decreased, the possible tumor development is delayed and smaller-sized tumors are observed (5-11). Currently, a longer survival time is observed in individuals after cancer treatment who regularly exercise (12)(13)(14)(15)(16)(17). Holmes et al. demonstrated a reduction in the risk of death due to breast cancer in women who exercised (3-5 hours per week) after treatment compared to women with a sedentary lifestyle (18). Other research groups have confirmed these results (19)(20)(21)(22). Walsh et al. and Daroux-Cole et al. suggested that exercise stimulated the immune system in cancer patients (23,24). Fairey et al. found an increase in the number of NK cells in the blood of women who trained and had previously undergone breast cancer treatment (13). It should also be noted that Demarzo and Garcia demonstrated an increase of breast tumor incidence in rats after intense exercise compared to untrained rats (25). Experiments on rats are a recognized model of experimental breast cancer research. The mammary gland model of rodents shows a significant similarity to the human mammary gland. In rodents, terminal end buds are the basic structures forming the mammary ridge while in humans it is the duct lobular unit which forms the 249 This article is freely accessible online.

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confidence: 77%

The Impact of Exercise Training on Breast Cancer

Siewierska

Malicka

Kobierzycki

et al. 2018

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“…However, our results suggest that the metabolic abnormalities and depression observed in BCS may not be attributable to low cardiorespiratory fitness, as these risk factors were present even though a higher VO 2 max was observed in BCS than non-cancer controls. Despite this finding, many studies suggest that depressive symptoms and metabolic dysfunction improve with exercise in BCS [ 44 – 46 ].…”

Section: Discussionmentioning

confidence: 99%

Increased depression and metabolic risk in postmenopausal breast cancer survivors

Serra

Goldberg

Ryan

2016

Diabetol Metab Syndr

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Objective: Breast cancer survivors (BCS) are at high risk for the development of obesity, type 2 diabetes mellitus, and metabolic syndrome. There is increasing interest in the association between depression and metabolic dysfunction, which is relevant in this population as depression is often present in the chronic phase of cancer recovery. Thus, the aim of this study was to evaluate metabolic risk in BCS with and without depression compared to non-cancer controls.Methods: African American (46 %) and Caucasian (54 %) postmenopausal BCS (N = 28; age: 60 ± 2 years; mean ± SEM) were matched for race, age (±2 years), and BMI (±2 kg/m 2 ) to non-cancer controls (N = 28). Center for Epidemiologic Studies Depression Scale (CES-D) >16 or antidepressant medication usage was used to classify depression. Metabolic status was defined by 2-hr glucose during an OGTT and classification of metabolic syndrome.Results: Compared to non-cancer controls, BCS had similar 2-hr glucose, but higher fasting glucose and total cholesterol, and were 2.5 times more likely to have metabolic syndrome (21 vs. 52 %)(P's < 0.05). Conversely, HDL-C was 16 % higher in BCS (P < 0.05). Forty three % of BCS were on antidepressants compared to 14 % in non-cancer controls, despite similar mean CES-D scores (6 ± 1). Depressed BCS (46 %) had a higher BMI, waist circumference, fasting glucose, and more metabolic syndrome components than non-depressed BCS (P's < 0.05). Conclusions:BCS have a heightened prevalence of depression that may be associated with an increased prevalence of metabolic syndrome. These results support the need to monitor weight gain, depression, and the progression of metabolic abnormalities after cancer diagnosis and treatment. Further studies into the mechanistic link between depression and metabolic disease are necessary to identify strategies that can offset their impact on obesity and associated cardiovascular risk following a breast cancer diagnosis.

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“…The growing number of data have shown that metabolic syndrome (MetS) and its independent components are related with plethora of cancers, including a higher risk of having breast cancer (Esposito et al 2012;Uzunlulu, Telci Caklili, and Oguz 2016;Park et al 2017). Similarly, breast cancer survivors were also reported to be susceptible to MetS (Bhandari et al 2014;Bao et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Metabolic Syndrome among Breast Cancer Survivors in East Coast of Peninsular Malaysia

Amirfaiz

Shahril

Lua

et al. 2020

Preprint

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To date, limited data are available on metabolic syndrome (MetS) prevalence among breast cancer survivors in Malaysia. Therefore, this study was conducted to determine the prevalence of MetS and abnormal MetS components among breast cancer survivors in East Coast of Peninsular Malaysia. This cross-sectional study included 95 breast cancer survivors (age 53.7±7.6 years) who have completed main cancer treatments for ≥6 months. Cancer survivors were recruited from two main government hospitals in Kelantan and Terengganu using a purposive sampling method. According to the Harmonized criteria, the MetS prevalence was 50.5%. Among those with MetS, the most prevalent abnormal metabolic components were triglycerides (91.2%), fasting blood glucose (79.6%) and HDL-c level (78.4%). Except for total cholesterol and LDL-c, all other MetS components were significantly different (p<0.05) between those with and without MetS. Significant differences between MetS and non-MetS groups were found for weight, BMI, waist circumference, body fat percentage and cancer stages (p<0.05). Otherwise, no significant difference was reported in other sociodemographic and clinical parameters between cancer survivors with and without MetS. In conclusion, MetS was highly prevalent among breast cancer survivors in this study, with weight, BMI, waist circumference, body fat percentage and cancer stages significantly affect MetS status.

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Exercise after diagnosis and metabolic syndrome among breast cancer survivors: a report from the Shanghai Breast Cancer Survival Study

Cited by 27 publications

References 41 publications

The Impact of Exercise Training on Breast Cancer

The Impact of Exercise Training on Breast Cancer

Increased depression and metabolic risk in postmenopausal breast cancer survivors

Prevalence of Metabolic Syndrome among Breast Cancer Survivors in East Coast of Peninsular Malaysia

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