Impact of Pre-Storage and Bedside Filtered Leukocyte-Depleted Blood Transfusions on Infective Morbidity after Colorectal Resection: A Single-Center Analysis of 437 Patients

Abstract

Leukocyte-depleted blood transfusions and, in particular, bedside-filtered blood have a significant negative effect on infectious complications after colorectal resection.

Incidence and Risk Factors for Organ/Space Infection after Radiofrequency-Assisted Hepatectomy or Ablation of Liver Tumors in a Single Center: More than Meets the Eye

“…Our data indicate that blood transfusion has no effect on the development of SSI in liver surgery. However, we cannot draw any conclusion on the effect of the type of transfused blood, as described in colorectal surgery (25), and suggested by Okabayashi et al (15) because only one of our patients received leukocyte-depleted blood.…”

Effect of post-storage filters vs. pre-storage filters for leukoreduction of blood components on clinical outcomes: A systematic review

“…An allergic reaction was found in 75% of the studies analyzed 19,20,[44][45][46] , but it was not considered an outcome in this review because leukoreduction is not an indication for preventing it since its pathophysiology is different from that of FNHTRs and is related to the presence of anti-IgE antibodies in the receptor 4 . Two studies 21,25 analyzed the presence of postsurgical infection for immunomodulation, but one study showed that surgery had a high potential for contamination (colorectal resection) 21 .…”

“…It is important to note that the risk of selection bias is important in studies that analyzed data from before and after the adoption of pre-storage leukoreduction in all transfusions since the sample of patients who received transfusions with post-storage leukoreduction was more restricted and had a higher risk of TR, as already mentioned 20,43,45,46 . The answers to question 6 were unclear in four studies 19,21,43,45 , as there was no report on the follow-up time for evaluating the outcomes. Question 5 was considered not applicable to the quasi-experimental studies of interest for this review because TRs are only transfusional if they occur after the intervention (transfusion), and there is no reason to evaluate them before transfusions.…”

“…A total of 796 records were excluded from screening titles and abstracts because of the pertinence of the study for review. The remaining 26 reports were read in full to con rm their relevance for the review, and 17 were excluded for failing to meet the inclusion criteria 24,[27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42] ; thus, nine studies [19][20][21]25,[43][44][45][46][47] were included in this review.…”

“…Although the bene ts of leukoreduction are recognized, pre-storage leukoreduction has advantages over post-storage, including preventing the accumulation of cytokines that are synthesized during cell storage, preventing RBC hemolysis and interruption of ltration by cell debris resulting from the storage of RBCs and ensuring quality control of the leukoreduction of products intended for transfusion 6,10,19 . Some studies comparing the use of blood components subjected to pre and post-storage ltration have shown that pre-storage leukoreduction is more advantageous for reducing TRs, infection, and postoperative mortality, especially in patients with cancer, transplants, or hematological diseases [19][20][21] . However, other studies have not shown a difference between the ltration time (before and after storage) and the clinical outcome of transfusion patients 24,25 .…”