Preface

Brown, Edward M.; Conigrave, Arthur D.

doi:10.1016/j.beem.2013.05.009

Cited by 3 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, Ca 2+ acts as a multipurpose messenger, exerting effects at the cellular, subcellular, and extracellular levels. A very interesting and comprehensive list of reviews on the CaR has been recently published by leading experts in the field of extracellular Calcium-sensing and signalling [ 7 ]. Other key topics, such as the structure-function relationships [ 8 ] and role of the CaR in cancer [ 9 ], have also been very recently covered elsewhere and will be named here in the corresponding paragraphs.…”

Section: Introductionmentioning

confidence: 99%

The Different Facets of Extracellular Calcium Sensors: Old and New Concepts in Calcium-Sensing Receptor Signalling and Pharmacology

Gerbino

Colella

2018

IJMS

View full text Add to dashboard Cite

The current interest of the scientific community for research in the field of calcium sensing in general and on the calcium-sensing Receptor (CaR) in particular is demonstrated by the still increasing number of papers published on this topic. The extracellular calcium-sensing receptor is the best-known G-protein-coupled receptor (GPCR) able to sense external Ca2+ changes. Widely recognized as a fundamental player in systemic Ca2+ homeostasis, the CaR is ubiquitously expressed in the human body where it activates multiple signalling pathways. In this review, old and new notions regarding the mechanisms by which extracellular Ca2+ microdomains are created and the tools available to measure them are analyzed. After a survey of the main signalling pathways triggered by the CaR, a special attention is reserved for the emerging concepts regarding CaR function in the heart, CaR trafficking and pharmacology. Finally, an overview on other Ca2+ sensors is provided.

show abstract

Section: Introductionmentioning

confidence: 99%

The Different Facets of Extracellular Calcium Sensors: Old and New Concepts in Calcium-Sensing Receptor Signalling and Pharmacology

Gerbino

Colella

2018

IJMS

View full text Add to dashboard Cite

show abstract

“…It regulates Ca 2+ and other metal ion homeostasis and promotes cell proliferation and differentiation. [14,15] Extracellular environmental stress can activate CaSR and increase intracellular calcium ions concentration, hence affecting the release of transforming growth factor 𝛽 (TGF-𝛽). [16,17] And studies demonstrate that TGF-𝛽 is crucial for bone homeostasis via the TGF-𝛽-type I/II receptors (T𝛽RI/II)-Smad2/3 pathway, which induces osteoblast proliferation, differentiation, and mineralization.…”

Section: Introductionmentioning

confidence: 99%

Novel Calcium‐Binding Peptide from Bovine Bone Collagen Hydrolysates and Its Potential Pro‐Osteogenic Activity via Calcium‐Sensing Receptor (CaSR)

Qi,

Zhang,

Guo

et al. 2023

Molecular Nutrition Food Res

View full text Add to dashboard Cite

ScopeThis paper aims to explore the osteogenic activity and potential mechanism of the peptide‐calcium chelate, and provides a theoretical basis for peptide‐calcium chelates as functional foods to prevent or improve osteoporosis.Methods and resultsIn this research, a novel peptide (Phe‐Gly‐Leu, FGL) with a high calcium‐binding capacity is screened from bovine bone collagen hydrolysates (CPs), calcium binding sites of which mainly included carbonyl, amino and carboxyl groups. The FGL‐Ca significantly enhances the osteogenic activity of MC3T3‐E1 cells (survival rate, differentiation, and mineralization). The results of calcium fluorescence labeling and molecular docking show that FGL‐Ca may activate calcium‐sensing receptor (CaSR), leading to an increase in intracellular calcium concentration, then enhancing osteogenic activity of MC3T3‐E1 cells. Further research found that FGL‐Ca significantly promotes the mRNA and protein expression levels of CaSR, transforming growth factor β (TGF‐β1), TGF‐β‐type II receptor (TβRII), Smad2, Smad3, osteocalcin (OCN), alkaline phosphatase (ALP), osteoprotegrin (OPG), and collagen type I (COLI). Subsequently, in the signal pathway intervention experiment, the expression levels of genes and proteins related to the TGF‐β1/Smad2/3 signaling pathway that are promoted by FGL‐Ca are found to decrease.ConclusionsThese results suggest that FGL‐Ca may activate CaSR, increase intracellular calcium concentration, and activate TGF‐β1/Smad2/3 signaling pathway, which may be one of the potential mechanisms for enhancing osteogenic activity.

show abstract

“…However, the CaR is also a factor in other more common pathologies that include chronic kidney disease 6 , cancer 7 , cardiovascular pathologies 8 – 11 , and Alzheimer’s disease 12 . For a complete survey of CaR’s function in molecular physiology and pathology, readers are referred to some of the many recent reviews on the topic 13 .…”

Section: Introductionmentioning

confidence: 99%

Recent advances in understanding the extracellular calcium-sensing receptor

et al. 2016

View full text Add to dashboard Cite

The extracellular calcium-sensing receptor (CaR), a ubiquitous class C G-protein-coupled receptor (GPCR), is responsible for the control of calcium homeostasis in body fluids. It integrates information about external Ca 2+ and a surfeit of other endogenous ligands into multiple intracellular signals, but how is this achieved? This review will focus on some of the exciting concepts in CaR signaling and pharmacology that have emerged in the last few years.

show abstract

Preface

Cited by 3 publications

References 0 publications

The Different Facets of Extracellular Calcium Sensors: Old and New Concepts in Calcium-Sensing Receptor Signalling and Pharmacology

The Different Facets of Extracellular Calcium Sensors: Old and New Concepts in Calcium-Sensing Receptor Signalling and Pharmacology

Novel Calcium‐Binding Peptide from Bovine Bone Collagen Hydrolysates and Its Potential Pro‐Osteogenic Activity via Calcium‐Sensing Receptor (CaSR)

Recent advances in understanding the extracellular calcium-sensing receptor

Contact Info

Product

Resources

About