Dexmedetomidine Reduced Cytokine Release during Postpartum Bleeding-Induced Multiple Organ Dysfunction Syndrome in Rats

Abstract

Dexmedetomidine (DEX) is an α2-adrenergic agonist. It decreases the levels of norepinephrine release, resulting in a reduction of postsynaptic adrenergic activity. In the present study, the effects of DEX on postpartum bleeding-induced multiple organ dysfunction syndrome (BMODS) were studied in rats in which BMODS was induced by the combination of hypotension and clamping of the superior mesenteric artery. We evaluated the role of dexmedetomidine (DEX) in cytokine release during postpartum BMODS in rats. In summary, the present study demonstrated that DEX administration reduced IFN-r and IL-4 release and decreased lung injury during postpartum BMODS. It is possible that DEX administration decreased inflammatory cytokine production in BMODS by inhibiting inflammation and free radical release by leukocytes independent of the DEX dose.

Role of Intravenous Dexmedetomidine in Prolonging Postoperative Analgesia and Quality of Block Following Spinal Anaesthesia. A Systemic Review and Update

“…Dexmedetomidine has been shown to have organ protective effects in animal models particularly in modulation of cytokine and inflammatory mediators in variety of ischaemia and ischemic-reperfusion injury in animal [78][79][80][81][82][83]. However, such protective effects are not evident in human studies.…”

Dexmedetomidine Analgesia Effects in Patients Undergoing Dental Implant Surgery and Its Impact on Postoperative Inflammatory and Oxidative Stress

“…Along with its beneficial effects, DEX was reported to exert potential anti-inflammatory and antioxidant effects. Previous studies revealed that DEX significantly decreased the levels of inflammatory cytokines during postpartum bleeding-induced multiple organ dysfunction syndrome in rats [ 16 ], in polymicrobial sepsis in mice [ 17 ], during cardiac surgery with cardiopulmonary bypass in human [ 18 ], and in lung injury in dogs [ 19 ] and laparoscopic cholecystectomy in human [ 20 ]. DEX also significantly decreased the levels of free radicals on ischemia-reperfusion injury of epigastric island flaps of rats [ 21 ] and ischemic rat hippocampus [ 22 ].…”

Intercellular adhesion molecule-1 and S-100β in sevoflurane combined with epidural anesthesia for radical resection of lung cancer

“…Studies have found that S-100β is a calcium binding protein of low molecular weight and is found in glial cells of central and peripheral nervous systems (9,10). S-100β in serum is at physiologically low concentration in healthy population, and not easy to detect, but the expression in serum of brain injured people is abnormally increased (11)(12)(13). The level of S-100β in patients' serum can evaluate cognitive function, but its prognostic value in lung cancer has not been studied.…”