Intercellular adhesion molecule-1 and S-100β in sevoflurane combined with epidural anesthesia for radical resection of lung cancer

Abstract

Significance of intercellular adhesion molecule-1 (ICAM-1) and S-100β protein (S-100β) were investigated in sevoflurane combined with epidural anesthesia for radical resection of lung cancer. In total, 172 patients who underwent radical resection of lung cancer from May 2014 to January 2016 and 160 blood samples from healthy patients in the same period were selected for prospective analysis. Lung cancer patients were the therapy group (TG). Venous blood (2 ml) was taken from patients before anesthesia (T1) and after anesthesia at 30 min (T2), 3 h (T3) and 24 h (T4), respectively. Healthy physical examination samples were the control group (CG). Enzyme linked immunosorbent assay (ELISA) was used to detect the concentration of ICAM-1 and RT-PCR to detect the concentration of S-100β. The changes of ICAM-1 and S-100β concentrations and their significance to patients were analyzed. The serum ICAM-1 and S-100β concentrations in TG were significantly higher than those in CG (P<0.001), and were the highest at T1 (P>0.001), followed by T2 (P<0.001). Of the 172 patients 27 cases had adverse complications during the perioperative period. Patients were divided into the ICAM-1 high concentration group (CHCG), the ICAM-1 low concentration group (CLCG) and the S-100β high concentration group (SHCG) and the S-100β low concentration group (SLCG). The 3-year survival rate of CHCG was significantly lower than CLCG and SLCG (P<0.001). ICAM-1 and S-100β protein in sevoflurane combined with epidural anesthesia for radical resection of lung cancer can effectively predict the perioperative adverse complications of patients, and have better monitoring significance for the prognosis of patients.

From multi-omics integration towards novel genomic interaction networks to identify key cancer cell line characteristics

“…Aberrant expression of REG4 is associated with tumor growth, survival, adhesion but also resistance to apoptosis 23 . Elevated expression of FN1 cluster 8 is of interest, because FN1 is an important gene involved in the development of various cancer types driving proliferation 24 , 25 . AXL expression is associated with various processes in cancer, including proliferation, survival, metastasis and resistance to cancer therapy 26 .…”