Factors that make it difficult to diagnose cervical tuberculous lymphadenitis

Tachibana, Tomoyasu; Orita, Yorihisa; Fujisawa, Masayoshi; Nakada, Michihiro; Ogawara, Yuya; Matsuyama, Yuko; Abe, Iku; Sato, Yasuharu; Uesaka, Katsuhiko; Nishizaki, Kazunori

doi:10.1007/s10156-013-0615-8

Cited by 11 publications

(18 citation statements)

References 17 publications

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“…13,14 FNAC was able to come up with a diagnosis in 83% (29/35) patients where biopsy was not possible, emphasizing the diagnostic utility of FNAC even when biopsy is difficult. 15 FNAC was found to be a highly accurate method in the diagnosis of TB; with a sensitivity of over ninety percent and a specificity of 100%.This compares favorably with other studies done elsewhere in the developing world where TB is endemic. 10,16 These findings were different from studies done in the developed world where TB is not endemic, where FNA was found to have a very low sensitivity of 46% in the diagnosis of TBLN.…”

Section: Diagnostic Accuracysupporting

confidence: 63%

Diagnostic accuracy of fine needle aspiration cytology in providing a diagnosis of cervical lymphadenopathy among HIV-infected patients

Muyanja¹,

Kalyesubula²,

Namukwaya³

et al. 2015

Afr H. Sci.

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Background: Opportunistic infections and malignancies cause lymphadenopathy in HIV-infected patients. The use and accuracy of fine needle aspiration cytology in diagnosing of cervical lymphadenopathy among HIV-infected patients is not well studied in Uganda. Objective: The aim of this study was to determine the diagnostic accuracy of fine needle aspiration cytology in providing a diagnosis of cervical lymphadenopathy among HIV-infected patients in Uganda. Methods: We consecutively recruited adult HIV-infected patients with cervical lymphadenopathy admitted to Mulago Hospital medical wards. Clinical examination, fine needle aspiration and lymph node biopsy were performed. We estimated the sensitivity, specificity; negative and positive predictive values using histology as the gold standard. Results: We enrolled 108 patients with a mean age of 33 years (range, 18-60), 59% were men and mean CD4 was 83(range, 22-375) cells/mm

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Section: Diagnostic Accuracysupporting

confidence: 63%

Diagnostic accuracy of fine needle aspiration cytology in providing a diagnosis of cervical lymphadenopathy among HIV-infected patients

Muyanja¹,

Kalyesubula²,

Namukwaya³

et al. 2015

Afr H. Sci.

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“…Five articles had data on patient delay [20, 22-25], three on health care delay [19, 26, 27], and three on total delay [21, 28, 29]. …”

Section: Resultsmentioning

confidence: 99%

“…The case definition of TBLA was inconsistent in the different studies with specimens examined with microscopy, culture, polymerase chain reaction, and pathology, and/or cases based on clinical assessment. Most samples were collected using fine-needle aspiration (FNA) and/or excisional biopsy [19, 20, 23-29]. A single article had no information on the type of biopsy [21], while another study used bronchoalveolar lavage fluid, lumbar puncture, paracentesis of ascites fluid, and surgically obtained abdominal biopsies [22].…”

Section: Resultsmentioning

confidence: 99%

“…1). Eleven articles from seven different countries around the world, mainly Europe, were eligible for inclusion [19-29]. All studies except one, specifically designed to investigate delay [27], focused on clinical and diagnostic features in TBLA patients.…”

Section: Resultsmentioning

confidence: 99%

“…We used the terms patient, health care, and total delay, and summarized articles according to these (Table 1). For one study, the mean delay was calculated by the authors based on the values from single observations presented in the article [19]. For readability and comparability, delays presented as weeks or months were calculated into days as 7 and 30.43 days, respectively.…”

Section: Methodsmentioning

confidence: 99%

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Delays in the Diagnosis and Treatment of Tuberculous Lymphadenitis in Low-Incidence Countries: A Systematic Review

et al. 2019

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Early detection and treatment of tuberculosis (TB) is essential to achieve the goals appointed in the WHO End TB Strategy. Tuberculous lymphadenitis (TBLA) is the most common manifestation of extrapulmonary TB, but the diagnosis can be challenging in low-incidence countries due to sparse and inconsistent clinical features, resulting in delay. We aimed to summarize and discuss the current literature on patient delay, health care delay, and total delay (i.e., time to first health care contact, diagnosis, and treatment) in patients with TBLA in TB low-incidence countries. A systematic review using PubMed was conducted, searching for studies set in TB low-incidence countries (defined as <20 per 100,000 citizens) that reported on health care seeking behaviour, patient delay, health care delay, and/or total delay. Studies were categorized by type of delay and compared. We identified 11 heterogeneous studies with highly variable observations. Mean patient delay varied from 55 to 154 days (range, 14–1,461), mean health care delay from 44 to 94 days (range, 7–224) and median total delay from 77.5 to 122 days (range, 0–2,820). Evidently, more comprehensive insights into the diagnostic pathway and delay in TBLA patients are warranted.

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A rare case of cervical tuberculous lymphadenitis followed by impaired consciousness

Hirayama

Nagata

Yoshida

et al. 2022

Journal of Oral and Maxillofacial Surgery, Medicine, and Pathol

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Factors that make it difficult to diagnose cervical tuberculous lymphadenitis

Cited by 11 publications

References 17 publications

Diagnostic accuracy of fine needle aspiration cytology in providing a diagnosis of cervical lymphadenopathy among HIV-infected patients

Diagnostic accuracy of fine needle aspiration cytology in providing a diagnosis of cervical lymphadenopathy among HIV-infected patients

Delays in the Diagnosis and Treatment of Tuberculous Lymphadenitis in Low-Incidence Countries: A Systematic Review

A rare case of cervical tuberculous lymphadenitis followed by impaired consciousness

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