The effect of nebulized salbutamol or isotonic saline on exercise-induced bronchoconstriction in elite skaters following a 1,500-meter race: study protocol for a randomized controlled trial

Driessen, J.M.M.; Gerritsma, M.; Westbroek, Jaap; Hacken, Nick H. T. ten; Jongh, Franciscus H.C. de

doi:10.1186/1745-6215-14-204

Cited by 2 publications

(2 citation statements)

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“…Short-acting β2-agonists are used therapeutically by athletes with asthma related conditions to prevent and/or reverse the bronchoconstriction of the airways, leading to restoration of airway function. [1][2][3][4][5] The majority of athletes treat symptoms of exercise-induced bronchoconstriction (EIB) through the use of salbutamol, making it the most commonly used inhaled β2agonist in these individuals. 4 However other β2-agonists, such as terbutaline, are available which is a suitable alternative to salbutamol, should an athlete not respond appropriately to salbutamol treatment.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Inhaled Terbutaline on 3-km Running Time-Trial Performance

Molphy¹,

Dickinson²,

Chester³

et al. 2019

International Journal of Sports Physiology and Performance

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Terbutaline is a prohibited drug except for athletes with a therapeutic use exemption certificate; terbutaline’s effects on endurance performance are relatively unknown. Purpose: To investigate the effects of 2 therapeutic (2 and 4 mg) inhaled doses of terbutaline on 3-km running time-trial performance. Methods: A total of 8 men (age 24.3 [2.4] y; weight 77.6 [8] kg; and height 179.5 [4.3] cm) and 8 women (age 22.4 [3] y; weight 58.6 [6] kg; and height 163 [9.2] cm) free from respiratory disease and illness provided written informed consent. Participants completed 3-km running time trials on a nonmotorized treadmill on 3 separate occasions following placebo and 2- and 4-mg inhaled terbutaline in a single-blind, repeated-measures design. Urine samples (15 min postexercise) were analyzed for terbutaline concentration. Data were analyzed using 1-way repeated-measures analysis of variance, and significance was set at P < .05 for all analyses. Results: No differences were observed for completion times (1103 [201] s, 1106 [195] s, 1098 [165] s; P = .913) for the placebo or 2- and 4-mg inhaled trials, respectively. Lactate values were higher (P = .02) after 4 mg terbutaline (10.7 [2.3] mmol·L−1) vs placebo (8.9 [1.8] mmol·L−1). Values of forced expiratory volume in the first second of expiration (FEV1) were greater after inhalation of 2 mg (5.08 [0.2]; P = .01) and 4 mg terbutaline (5.07 [0.2]; P = .02) compared with placebo (4.83 [0.5] L) postinhalation. Urinary terbutaline concentrations were mean 306 (288) ng·mL−1 and 435 (410) ng·mL−1 (P = .2) and peak 956 ng·mL−1 and 1244 ng·mL−1 after 2 and 4 mg inhaled terbutaline, respectively. No differences were observed between the male and female participants. Conclusions: Therapeutic dosing of terbutaline does not lead to an improvement in 3-km running performance despite significantly increased FEV1. The findings suggest that athletes using inhaled terbutaline at high therapeutic doses to treat asthma will not gain an ergogenic advantage during 3-km running performance.

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Section: Introductionmentioning

confidence: 99%

The Effects of Inhaled Terbutaline on 3-km Running Time-Trial Performance

Molphy¹,

Dickinson²,

Chester³

et al. 2019

International Journal of Sports Physiology and Performance

View full text Add to dashboard Cite

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“…In recent decades, the pages of medical publications were dedicated to the search for methods for predicting the occurrence of exercise-induced bronchial obstruction in athletes [9,10]. It has been shown that the subjective symptoms of exercise-induced bronchial obstruction before and after beta2-agonist administration do not correlate with the changes in airway caliber in athletes.…”

Section: Introductionmentioning

confidence: 99%

Changes in Cardiovascular and Respiratory Systems in Young Athletes

Сенаторова

Onikiienko

2020

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Changes in cardiorespiratory complex of adult athletes are the subject of scientific researches. However, there is a lack of researches that would assess such changes in children and adolescents involved in intensive physical training. The purpose of the study was to evaluate functional and morphological changes of cardiovascular and respiratory systems in boys of primary school age engaged in football. Materials and methods. 109 male children aged 10-11 years were enrolled in the study, among which 81 children have been attending sports football schools, 28 children didn’t have regular physical activity. The study design included a general clinical examination, a spirometry, the condition of cardiovascular system was assessed with echocardiography, and ambulatory blood pressure monitoring (ABPM). Results. The boys 10-11 years of age who play sports have higher values of minute respiratory volume and cardiac indices, which may support the hypothesis of the myocardial hypertrophy development, although they correspond to normal Z-score values. According to ABPM results the duration of physical activity may influence on transition from vasodilation to vasoconstriction. Conclusions. We obtained statistically significant quantitative differences in the functional state of the cardiovascular and respiratory systems in children-athletes. The changes found in young athletes may result to further supervision of a pediatric cardiologist, but decision should be made individually.

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The effect of nebulized salbutamol or isotonic saline on exercise-induced bronchoconstriction in elite skaters following a 1,500-meter race: study protocol for a randomized controlled trial

Cited by 2 publications

References 18 publications

The Effects of Inhaled Terbutaline on 3-km Running Time-Trial Performance

The Effects of Inhaled Terbutaline on 3-km Running Time-Trial Performance

Changes in Cardiovascular and Respiratory Systems in Young Athletes

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