Low-glycaemic index diets in the management of blood lipids: a systematic review and meta-analysis

Fleming, Patrick; Godwin, Marshall

doi:10.1093/fampra/cmt029

Cited by 30 publications

(23 citation statements)

References 14 publications

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“…Medium-chain fatty acids have also been found to reduce cholesterol, triglycerides and lipoproteins levels 36 . Interestingly, several studies also suggest that preferential intake of low-glycaemic index carbohydrates reduces lipid blood content 45, 46 . Growth retardation is also a detrimental side effect often observed in children on KD.…”

Section: Discussionmentioning

confidence: 99%

“…~10% in the MAD) and similar proportions of proteins and fat. Given the beneficial impact of polyunsaturated fatty acids and low glycaemic index 46 on health parameters including blood lipid content, and the manageability of medium-chain triglycerides gastrointestinal side effects, it is also reasonable to anticipate that the CD approach may be well tolerated by patients.…”

Section: Discussionmentioning

confidence: 99%

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Non-ketogenic combination of nutritional strategies provides robust protection against seizures

Dallérac

Moulard

Benoist

et al. 2017

Sci Rep

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Epilepsy is a neurological condition that affects 1% of the world population. Conventional treatments of epilepsy use drugs targeting neuronal excitability, inhibitory or excitatory transmission. Yet, one third of patients presents an intractable form of epilepsy and fails to respond to pharmacological anti-epileptic strategies. The ketogenic diet is a well-established non-pharmacological treatment that has been proven to be effective in reducing seizure frequency in the pharmaco-resistant patients. This dietary solution is however extremely restrictive and can be associated with complications caused by the high [fat]:[carbohydrate + protein] ratio. Recent advances suggest that the traditional 4:1 ratio of the ketogenic diet is not a requisite for its therapeutic effect. We show here that combining nutritional strategies targeting specific amino-acids, carbohydrates and fatty acids with a low [fat]:[proteins + carbohydrates] ratio also reduces excitatory drive and protects against seizures to the same extent as the ketogenic diet. Similarly, the morphological and molecular correlates of temporal lobe seizures were reduced in animals fed with the combined diet. These results provide evidence that low-fat dietary strategies more palatable than the ketogenic diet could be useful in epilepsy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Non-ketogenic combination of nutritional strategies provides robust protection against seizures

Dallérac

Moulard

Benoist

et al. 2017

Sci Rep

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“…We found five meta-analyses which studied effects of GI on HDL-C [4][5][6][7][8]. All meta-analyses denied a significant effect of GI on HDL-C.…”

Section: Effects Of Gi On Hdl-cmentioning

confidence: 99%

“…All meta-analyses denied a significant effect of GI on HDL-C. However, three meta-analyses showed that compared with high GI, low GI reduced total cholesterol (TC) and low-density lipoprotein (LDL)-C [5][6][7]. Only one meta-analysis showed that low GI significantly reduced triglyceride (TG) [4]; however, other four studies challenged a significant effect of low GI on TG.…”

Section: Effects Of Gi On Hdl-cmentioning

confidence: 99%

“…Fleming P, et al [5] RCTs on the effect of low-GI diets on serum lipid levels 4 studies There was no significant effect on HDL-C levels Low-GI diets were shown to have a significant effect on decreasing TC and LDL-C over a short time span (5 -12 weeks). There was no significant effect on TG levels…”

Section: Assessed Studies Subjects Studied Effects On Hdl-c Effects Omentioning

confidence: 99%

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Effects of Glycemic Index and Intake of Dietary Fiber on Serum HDL-Cholesterol Levels

Yanai

Tada

2018

J Endocrinol Metab

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We previously studied effects of glycemic index (GI) and intake of dietary fiber on serum high-density lipoprotein (HDL)-C levels to make "Dietary Reference Intakes for Japanese 2015", by using data obtained by clinical trials which evaluated effects of GI and intake of dietary fiber on HDL-C in Asian populations. We found that low GI and an increased intake of dietary fiber may be beneficially associated with HDL metabolism. Here we review meta-analyses on the effects of GI and intake of dietary fiber on serum HDL-C levels, to make "Dietary Reference Intake for Japanese 2020". A search was conducted by using PubMed, Embase and Google Scholar, and the search period was comprised up to May 2018. In spite of significant associations of low GI and dietary fiber intake with reduction of low-density lipoprotein (LDL)-C, we could not observe any significant influences of low GI and dietary fiber intake on HDL metabolism.

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Low glycaemic index diets for the prevention of cardiovascular disease

Clar¹,

Al-Khudairy

Loveman³

et al. 2017

Cochrane Database of Systematic Reviews

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Low-glycaemic index diets in the management of blood lipids: a systematic review and meta-analysis

Abstract: This meta-analysis suggests that a low-GI diet may help lower total and LDL cholesterol. The generalizability of these findings is likely limited by heterogeneity in individual study definitions of low- or high-GI diets.

Cited by 30 publications

References 14 publications

Non-ketogenic combination of nutritional strategies provides robust protection against seizures

Non-ketogenic combination of nutritional strategies provides robust protection against seizures

Effects of Glycemic Index and Intake of Dietary Fiber on Serum HDL-Cholesterol Levels

Low glycaemic index diets for the prevention of cardiovascular disease

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