Macplocimine A, a new 18-membered macrolide isolated from the filamentous sulfur bacteria Thioploca sp.

Li, Xiang; Vanner, S; Wang, Wenliang; Li, Yongchang; Gallardo, Víctor A.; Magarvey, Nathan A.

doi:10.1038/ja.2013.52

Cited by 5 publications

(4 citation statements)

References 21 publications

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“…(benthic microbial mat, Chile). 171 Verrucosispora sp. (deep-sea sediment, S. China Sea) was the source of three further abyssomicin polyketides abyssomicin J-L 156-158.…”

Section: Marine-sourced Bacteria (Excluding From Mangroves)mentioning

confidence: 99%

Marine natural products

et al. 2015

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This review covers the literature published in 2013 for marine natural products (MNPs), with 982 citations (644 for the period January to December 2013) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1163 for 2013), together with the relevant biological activities, source organisms and country of origin. Reviews, biosynthetic studies, first syntheses, and syntheses that lead to the revision of structures or stereochemistries, have been included.

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“…(benthic microbial mat, Chile). 171 Verrucosispora sp. (deep-sea sediment, S. China Sea) was the source of three further abyssomicin polyketides abyssomicin J-L 156-158.…”

Section: Marine-sourced Bacteria (Excluding From Mangroves)mentioning

confidence: 99%

Marine natural products

et al. 2015

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“…e ., non-ribosomal peptide synthetase (NRPSs), and polyketide synthetase (PKSs) genes [ 30 ], presumably originating from cyanobacteria, as suggested after genome analysis of other vacuolated sulfur bacteria [ 30 , 31 ]. For example, a new macrolide compound, denominated Macplocimine A, was isolated from massive Thioploca -dominated mat samples, collected off central Chile [ 105 ].…”

Section: Resultsmentioning

confidence: 99%

Genomic features of “Candidatus Venteria ishoeyi”, a new sulfur-oxidizing macrobacterium from the Humboldt Sulfuretum off Chile

et al. 2017

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The Humboldt Sulfuretum (HS), in the productive Humboldt Eastern Boundary Current Upwelling Ecosystem, extends under the hypoxic waters of the Peru-Chile Undercurrent (ca. 6°S and ca. 36°S). Studies show that primeval sulfuretums held diverse prokaryotic life, and, while rare today, still sustain species-rich giant sulfur-oxidizing bacterial communities. We here present the genomic features of a new bacteria of the HS, “Candidatus Venteria ishoeyi” (“Ca. V. ishoeyi”) in the family Thiotrichaceae.Three identical filaments were micro-manipulated from reduced sediments collected off central Chile; their DNA was extracted, amplified, and sequenced by a Roche 454 GS FLX platform. Using three sequenced libraries and through de novo genome assembly, a draft genome of 5.7 Mbp, 495 scaffolds, and a N50 of 70 kbp, was obtained. The 16S rRNA gene phylogenetic analysis showed that “Ca. V. ishoeyi” is related to non-vacuolate forms presently known as Beggiatoa or Beggiatoa-like forms. The complete set of genes involved in respiratory nitrate-reduction to dinitrogen was identified in “Ca. V. ishoeyi”; including genes likely leading to ammonification. As expected, the sulfur-oxidation pathway reported for other sulfur-oxidizing bacteria were deduced and also, key inorganic and organic carbon acquisition related genes were identified. Unexpectedly, the genome of “Ca. V. ishoeyi” contained numerous CRISPR repeats and an I-F CRISPR-Cas type system gene coding array. Findings further show that, as a member of an eons-old marine ecosystem, “Ca. V. ishoeyi” contains the needed metabolic plasticity for life in an increasingly oxygenated and variable ocean.

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“…38 As for V12 and VS2, the amide structure may not facilitate the antiviral effect. However, the antiviral effects of these inhibitors in plant were not as good as predicted.…”

Section: Discussionmentioning

confidence: 99%

Discovery of novel inhibitors of RNA silencing suppressor P19 based on virtual screening

Lei

Deng

et al. 2018

RSC Adv.

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To control plant viruses, viral RNA silencing suppressors are important drug targets due to their key roles in interfering antiviral RNA silencing. Here we have presented a strategy, combining virtual and experimental screening, to discover the inhibitors of viral suppressor. By docking 157 026 compounds from a natural product library into P19 model, eighteen candidate compounds were selected. Candidates VS2, VS12, VS14 and VS15 displayed strong binding ability to P19 in the surface plasmon resonance imaging assay with K D values of 136.2, 111.6, 81.2 and 124.5 nM, respectively. Then the inhibition activities of these inhibitors on the association between P19 and siRNA were also affirmed by electrophoretic mobility shift assay. Moreover, the antiviral effects on plants showed that compounds VS14 and VS15 both exhibited antiviral activities against Tomato bushy stunt virus (TBSV) in vivo with inhibition rates of 32.35% and 16.61% in 11 dpi, respectively. This strategy would be a powerful tool for the discovery of novel antiviral agents and provide new insights into the control of plant viruses.

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Macplocimine A, a new 18-membered macrolide isolated from the filamentous sulfur bacteria Thioploca sp.

Cited by 5 publications

References 21 publications

Marine natural products

Marine natural products

Genomic features of “Candidatus Venteria ishoeyi”, a new sulfur-oxidizing macrobacterium from the Humboldt Sulfuretum off Chile

Discovery of novel inhibitors of RNA silencing suppressor P19 based on virtual screening

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