Binding deficits in memory following medial temporal lobe damage in patients with voltage-gated potassium channel complex antibody-associated limbic encephalitis
Abstract:Some prominent studies have claimed that the medial temporal lobe is not involved in retention of information over brief intervals of just a few seconds. However, in the last decade several investigations have reported that patients with medial temporal lobe damage exhibit an abnormally large number of errors when required to remember visual information over brief intervals. But the nature of the deficit and the type of error associated with medial temporal lobe lesions remains to be fully established. Voltage… Show more
“…relational binding task that we have developed (Pertzov et al, 2013), the number of swap (binding) errors does indeed increase with age.…”
Section: Memory At the Boundaries Between Normal And Abnormal Ageingmentioning
confidence: 87%
“…In fact, our "What was where?" relational memory task succeeded in showing a binding-specific deficit in both patients with focal medial temporal lobe disease (as a result of voltage-gated potassium channel antibody mediated encephalitis; Pertzov et al 2013) as well as asymptomatic mutation carriers for FAD . In both cases, recognition and localization performance was normal (as assessed by localization of one item and the "nearest item control" analysis for three items) but there was a specific impairment in associating the correct items to their correct locations.…”
Section: Format and Structure Of Memorymentioning
confidence: 99%
“…At present, it would appear that impairments in context-rich, relational binding memory functions such as those probed by the "What was where?" object-location test , Pertzov et al 2013, 2015 can be detected in the asymptomatic stage of AD, and are therefore potentially useful clinical research tools. …”
“…relational binding task that we have developed (Pertzov et al, 2013), the number of swap (binding) errors does indeed increase with age.…”
Section: Memory At the Boundaries Between Normal And Abnormal Ageingmentioning
confidence: 87%
“…In fact, our "What was where?" relational memory task succeeded in showing a binding-specific deficit in both patients with focal medial temporal lobe disease (as a result of voltage-gated potassium channel antibody mediated encephalitis; Pertzov et al 2013) as well as asymptomatic mutation carriers for FAD . In both cases, recognition and localization performance was normal (as assessed by localization of one item and the "nearest item control" analysis for three items) but there was a specific impairment in associating the correct items to their correct locations.…”
Section: Format and Structure Of Memorymentioning
confidence: 99%
“…At present, it would appear that impairments in context-rich, relational binding memory functions such as those probed by the "What was where?" object-location test , Pertzov et al 2013, 2015 can be detected in the asymptomatic stage of AD, and are therefore potentially useful clinical research tools. …”
“…VGKC-ab-associated LE showed good results towards the immunotherapy response (Vincent et al, 2004Barajas et al, 2010). Pertzov et al (2013) tested a group of VGKC-Ab patients using 2 newly developed visual short-term memory tasks with a sensitive and continuous measurements. These tests can be used to examine the nature of reporting errors.…”
ABSTRACT.A variety of anti-neuronal cell membrane antibodies such as voltage-gated potassium channel antibody, N-methyl-Daspartate-2B-antibody, and glutamic acid decarboxylase antibody, are correlated with limbic encephalitis (LE). In this study on patients with LE, the clinical manifestations, psychology Wechsler Adult Intelligence Scale, cerebrospinal fluid, electrophysiology, magnetic resonance imaging, and anti-immune therapy were studied and immunological determination was conducted; it was found that patients of Chinese Han nationality showed 2 types of clinical manifestations: simple and complex. Lesions could also be divided into focal and scalable lesions, and the clinical manifestations and lesions scopes were associated with various antibodies and antibody types. The prognosis may improve if early diagnosis is conducted and early anti-immune therapy is implemented in LE patients.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.