The effects of bupivacaine injection and oral nitric oxide on extraocular muscle in the rabbit

Abstract

Bupivacaine injection increased the EOM tension in rabbits to some extent. NO augmented the effect of bupivacaine.

Lidocaine Inhibits Myoblast Cell Migration and Myogenic Differentiation Through Activation of the Notch Pathway

“…After injection with LAs, muscles initially show degeneration and inflammation followed by regeneration with increased diameters of muscle fibers. 24 Satellite cells play a key role in this process. In this study, we investigated how one specific LA, lidocaine, affects satellite cells under laboratory conditions.…”

“…When using local anesthetics for treatment of strabismus, the tension of the EOMs sometimes increases after a longterm recovery period. 24 We propose that after the initial damage, EOMs experience a delay in the repair of these muscles due to a maintenance or even enlargement of satellite cell pools. The subsequent repair may eventually form muscle fibers of increased strength to provide the necessary forces required for appropriate eye alignment.…”