Nanomaterials for Reducing Amyloid Cytotoxicity

Zhang, Min; Mao, Xiaobo; Yu, Yue; Wang, Chenxuan; Yang, Yan; Wang, Chen

doi:10.1002/adma.201301210

Cited by 173 publications

(139 citation statements)

References 161 publications

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“…However, the delivery of diagnostic and therapeutic agents to the brain also is severely limited by the presence of the BBB [1][2][3][4]. To overcome this barrier, many delivery strategies have been attempted, such as local injection, induction of enhanced permeability and targeted delivery [5][6][7]. Unfortunately, delivery of diagnostic and therapeutic agents across the BBB is still a major challenge for Alzheimer's disease (AD), as well as for many other neurological diseases.…”

Section: Introductionmentioning

confidence: 98%

Sialic acid (SA)-modified selenium nanoparticles coated with a high blood–brain barrier permeability peptide-B6 peptide for potential use in Alzheimer’s disease

et al. 2015

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Section: Introductionmentioning

confidence: 98%

Sialic acid (SA)-modified selenium nanoparticles coated with a high blood–brain barrier permeability peptide-B6 peptide for potential use in Alzheimer’s disease

et al. 2015

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“…18–19 AuNPs are non-toxic, inert, biocompatible, and easily visible using microscopic and spectroscopic techniques as a result of their density and optical properties, respectively. 20 AuNPs with the size of a few to tens of nanometers exhibit a strong surface plasmon resonance (SPR) absorption band, primarily due to the coherent oscillation of nearly free conduction electrons. 21 The attributes of the SPR band are dependent on the size and shape of the nanoparticles themselves in addition to their surrounding media.…”

Section: Introductionmentioning

confidence: 99%

Gold Nanoparticles as a Probe for Amyloid-β Oligomer and Amyloid Formation

et al. 2017

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The process of amyloid-β (Aβ) amyloid formation is pathologically linked to Alzheimer’s disease (AD). The identification of Aβ amyloids and intermediates that are crucial players in the pathology of AD is critical for exploring the underlying mechanism of Aβ aggregation and the diagnosis of the disease. Herein, we performed a gold nanoparticle (AuNP)-based study to detect the formation of Aβ amyloid fibrils and oligomers. Our results demonstrate that the intensity of the surface plasmon resonance (SPR) absorption band of the AuNPs is sensitive to the quantity of Aβ40 amyloids. This allows the SPR assay to be used for detection and semi-quantification of Aβ40 amyloids, and characterization of the kinetics of Aβ amyloid formation. Furthermore, our study demonstrates that the SPR band intensity of the AuNPs is sensitive to the presence of oligomers of both Aβ40 and an Aβ40 mutant, which forms more stable oligomers. The kinetics of the stable oligomer formation of the Aβ40 mutant can also be monitored following the SPR band intensity change of AuNPs. Our results indicate that this nanoparticle based method can be used for mechanistic studies of early protein self-assembly and fibrillogenesis.

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“…7 Misfolding of hIAPP into amyloid fibrils with β-sheet structure is the most prominent hallmark of T2DM disease. 8,9 Therefore, the inhibition of amyloid fibril formation has been believed to be a potential strategy in the development of the therapy for T2DM and other neurodegenerative diseases. 10 On this account, the search for the inhibitors of fibril formation of amyloid peptides/proteins has become an active area of research and a variety of inhibitors has been studied and developed.…”

Section: Introductionmentioning

confidence: 99%

The effects of a series of carbon dots on fibrillation and cytotoxicity of human islet amyloid polypeptide

Wang

Zhu

et al. 2016

J. Mater. Chem. B

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Carbon dots (CDs) have been widely used as the candidates of drug carriers and bio-imaging probes because of their high drug loading capacity and intrinsic fluorescence property, as well as good biocompatibility. In this study, the potential role of CDs in regulating the aggregation behavior of human islet amyloid polypeptide (hIAPP) was explored for the first time. Five kinds of CDs belonging to three categories, namely polymer dots (PDs-1 and PDs-2), carbon nanodots (CNDs and CQDs), and graphene quantum dots (GQDs), were prepared and characterized. The fibrillation behaviors of hIAPP in the presence of these CDs were monitored by the ThT assay and TEM/AFM imaging and the cytotoxicity of the systems was tested by the MTT and LDH release assays. Our results showed that the polymer dots and carbon nanodots inhibit hIAPP fibrillation, while the GQDs promoted the formation of hIAPP fibrils. The PDs and GQDs that were nontoxic in INS-1 cells exerted efficiencies in decreasing the cell death induced by hIAPP through different mechanisms. The inhibitory activity and mechanism of the CDs were closely associated with their structures and surface properties. Our results shed light on a new potential application of CDs in therapeutics. .

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Nanomaterials for Reducing Amyloid Cytotoxicity

Cited by 173 publications

References 161 publications

Sialic acid (SA)-modified selenium nanoparticles coated with a high blood–brain barrier permeability peptide-B6 peptide for potential use in Alzheimer’s disease

Sialic acid (SA)-modified selenium nanoparticles coated with a high blood–brain barrier permeability peptide-B6 peptide for potential use in Alzheimer’s disease

Gold Nanoparticles as a Probe for Amyloid-β Oligomer and Amyloid Formation

The effects of a series of carbon dots on fibrillation and cytotoxicity of human islet amyloid polypeptide

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