Clinical and biometrological efficacy of a hyaluronic acid-based mesotherapy product: a randomised controlled study

Abstract

Data demonstrating the efficacy of hyaluronic acid (HA)-based mesotherapy for skin rejuvenation are scarce. The aim of the study is to assess the efficacy of non-reticulated HA-based mesotherapy on skin elasticity and complexion radiance. 55 women with cutaneous ageing signs included in the Full Analysis Set (FAS) population blindly received intradermal micro-injections (50 × 0.02 mL) of non-cross-linked HA filler with mannitol (Glytone 1, HA concentration: 14 mg/g) in one cheek and saline physiological solution in the other according to hemifacial randomisation in 3 monthly sessions. Elasticity (E1 and E2 stiffness parameters) and dermis thickness were measured by cutometry and 20 MHz echography, before (D0) treatment and 1 (1M) and 3 months (3M) after the last injection. A trained panel blindly scored skin complexion radiance from standardised and calibrated photographs, using 100 mm analogue scales. In the FAS population, only HA filler significantly decreased E1 at 1M (−10.9 %, p = 0.026) and 3M (−10.5 %, p = 0.035) compared with D0; its effect versus the control tended to be more persistent, with a difference between treatments at 3M close to significance (p = 0.063). E2 also decreased at 1M (−8.2 %, p = 0.027 in the per protocol population, n = 53) and 3M after HA-treatment only. Dermis thickness significantly increased after HA-treatment at 1M (+3.4 %, p = 0.028) and 3M (+4 %, p = 0.008), and after control-treatment at 1M only (+2.5 %, p = 0.015). The HA filler significantly improved complexion radiance at 3M compared with the control (p = 0.012) and for 51 % of subjects, their skin status. Non-reticulated HA-based mesotherapy significantly and sustainably improves skin elasticity and complexion radiance.

Free radical scavenging properties of mannitol and its role as a constituent of hyaluronic acid fillers: a literature review

“…To date, only a few studies have examined the combination of HA and mannitol in HA products for aesthetic use . HA mesotherapy products containing mannitol have shown improvements in skin viscoelasticity, dermal thickening and complexion compared with controls .…”

Effectiveness of Mesotherapy on Temporomandibular Joint Disorders

“…The necessary number of injections is variable and proportional to the area to treat, but the necessary dose is relatively lower than the needed by other methods. A lot of pathologies seem to benefit from this technique like tendinopathies, enthesopathies, fasciitis, muscular stretches, miofascial disorders, osteoarthritis and many others [23][24][25][26][27][28][29][30]. According to our knowledge there are no studies reporting the treatment effects of this technique in TMJD.…”

“…Till now, few studies had been published about mesotherapy method and no study about its effects on TMJD [23][24][25][26][27][28][29][30]. A lot of aspects should encourage the use of this method.…”

Clinical Assessment of a Mesotherapy Formulation for Skin Rejuvenation in Healthy Volunteers

“…Skin improvement may be explained by different actions: stimulation of injections and induced low inflammatory process and localized vasodilatation [35]. Injections and active compounds contribute to stimulate elastin and collagen synthesis.…”