Cells behaviors and genotoxicity on topological surface

Yang, Ning; Yang, Miaokun; Bi, Sixin; Chen, L.; Zhu, Zhengyan; Gao, Yingtang; Zhi, Du

doi:10.1016/j.msec.2013.04.035

Cited by 11 publications

(6 citation statements)

References 41 publications

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“…Studies have demonstrated that the surface property of biomaterials represents a very important factor with regard to the design of biomaterials because cell adhesion is largely influenced by the surface properties of artificial biomaterials [ 18 , 19 , 20 , 21 , 22 ]. Moreover, surface properties such as pore size, porosity, permeability, and physical/chemical properties not only impact cell proliferation but also control the direction of cell growth, as demonstrated in an artificial nerve guide conduit [ 23 , 24 ].…”

Section: Discussionmentioning

confidence: 99%

Morphology of Biomaterials Affect O-Glycosylation of HUVECs

Sheng

Guan

et al. 2022

JFB

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Biomaterials have been widely used as substitutes for diseased tissue in surgery and have gained great success and attention. At present, the biocompatibility of biomaterials such as PET woven fabrics is often evaluated both in vitro and in vivo. However, the current experimental methods cannot reveal the relationship between material surfaces and cell adhesion, and few research works have focused on the mechanisms of how the surface morphology of biomaterials affects cell adhesion and proliferation. Thus, it is meaningful to find out how the altered surfaces could affect cell adhesion and growth. In this study, we employed Ar low-temperature plasma treatment technology to create nano-grooves on the warp yarn of PET woven fabrics and seeded human umbellar vein endothelial cells (HUVEC) on these fabrics. We then assessed the O-glycan and N-glycan profiles of the cells grown on different structures of the polyester woven fabrics. The result showed that the surface morphology of polyester woven fabrics could affect the O-glycan profile but not the N-glycan profile of cultured HUVEC. Taken together, the study describes the effects of the surface morphology of biomaterial on the biosynthesis of cellular glycans and may provide new insights into the design and manufacture of biomaterials used as blood vessels based on the expression profiles of O-glycans on cultured cells.

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Section: Discussionmentioning

confidence: 99%

Morphology of Biomaterials Affect O-Glycosylation of HUVECs

Sheng

Guan

et al. 2022

JFB

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“… 22 As the cells adhere to the micropattern, internal mechanical stresses likely act to differentiate the cell, working to match features to function. 23 , 24 However, while sequestering the cells with microchannels may be beneficial to guide cells, the reduction in cell spreading and change in morphology may also generate genetic abnormalities (such as forming micronuclei), 25 , 26 making cell culture platforms with relevant length scales larger than the cells still more desirable. With this quality in mind, casting and embossing remain two of the more reproducible means to produce PS parts, especially on the industrial scale with injection molding equipment, and remain the method of choice for consumer and industrial parts.…”

Section: D Ps: the Basis Of In Vitro Cell Culturementioning

confidence: 99%

The Evolution of Polystyrene as a Cell Culture Material

Lerman

Lembong

Muramoto

et al. 2018

Tissue Engineering Part B: Reviews

197

156

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Polystyrene (PS) has brought in vitro cell culture from its humble beginnings to the modern era, propelling dozens of research fields along the way. This review discusses the development of the material, fabrication, and treatment approaches to create the culture material. However, native PS surfaces poorly facilitate cell adhesion and growth in vitro. To overcome this, liquid surface deposition, energetic plasma activation, and emerging functionalization methods transform the surface chemistry. This review seeks to highlight the many potential applications of the first widely accepted polymer growth surface. Although the majority of in vitro research occurs on two-dimensional surfaces, the importance of three-dimensional (3D) culture models cannot be overlooked. The methods to transition PS to specialized 3D culture surfaces are also reviewed. Specifically, casting, electrospinning, 3D printing, and microcarrier approaches to shift PS to a 3D culture surface are highlighted. The breadth of applications of the material makes it impossible to highlight every use, but the aim remains to demonstrate the versatility and potential as both a general and custom cell culture surface. The review concludes with emerging scaffolding approaches and, based on the findings, presents our insights on the future steps for PS as a tissue culture platform.

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“…[9,[42][43][44] Viscosity and surface morphology of the fabric, including coarseness, topography, porosity, and structure, may influence the ability for cell adhesion, proliferation, and migration. [45] Accordingly, cell behavior can vary as a function of the materials' surface. Figure 2.…”

Section: Surface Morphology Impacts Cell Adhesionmentioning

confidence: 99%

The significance of cadherin for cell–cell interactions and cell adhesions on biomaterials

Shen

et al. 2015

Journal of Adhesion Science and Technology

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Cadherins are surface glycoproteins on plasma membranes and exist in many forms: T-cadherin, neuronal cadherin (N-cadherin), epithelial cadherin (E-cadherin), and vascular endothelial (VE-cadherin). Cadherins play critical roles in cell-cell interactions and are involved in multiple functions related to cell growth and proliferation. Findings from numerous reports have indicated that VE-cadherin regulates the remodeling, gating, and maturation of vascular vessels. The surface morphology of materials also impacts endothelial cell adhesion. This report is an overview of recent research on the effects of cadherins on cell-cell interactions, along with cell adhesions as examined on different materials. This summary will provide novel insights and approaches for research on cell-cell and cell-material interactions and illuminate some of the mechanisms of cell growth on different materials.

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Cells behaviors and genotoxicity on topological surface

Cited by 11 publications

References 41 publications

Morphology of Biomaterials Affect O-Glycosylation of HUVECs

Morphology of Biomaterials Affect O-Glycosylation of HUVECs

The Evolution of Polystyrene as a Cell Culture Material

The significance of cadherin for cell–cell interactions and cell adhesions on biomaterials

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