“…Early randomized studies of brief intervention for drug use among adults found statistically significant effects for at least one of the primary outcomes (Baker et al, 2005; Bernstein et al, 2005; Copeland et al, 2001; Davis, Baer, Saxon, & Kivlahan, 2003; Humeniuk et al, 2012; McCambridge & Strang, 2004; Stephens, Roffman, & Curtin, 2000; Zahradnik et al, 2009), although some studies found no difference in outcomes (Marsden et al, 2006; Stein, Herman & Anderson, 2009; Woodruff et al, 2014). Also, published articles on SBIRT projects for drug use funded by the Substance Abuse and Mental Health Services Administration (SAMHSA) reported significant reductions in drug use and other problems from baseline to follow-up (Gryczynski et al, 2011; InSight Project Research Group, 2009; Madras et al, 2009; Woodruff, Eisenberg, McCabe, Clapp, & Hohman, 2013), although use of a single-group design in these projects precludes strong conclusions about the causal effect of SBIRT on drug use. The positive findings from this earlier body of research, however, have not been supported by two recent large randomized trials that found no significant effect on illicit drug use in primary healthcare settings (Roy-Byrne et al, 2014; Saitz et al, 2014).…”