Benefits of combining inspiratory muscle with ‘whole muscle’ training in children with cystic fibrosis: a randomised controlled trial

Santana‐Sosa, Elena; González-Saiz, Laura; Groeneveld, Iris F.; Villa-Asensi, José Ramón; Agüero, M.I. Barrio Gómez de; Fleck, Steven J.; López-Mojares, Luis M.; Pérez, Manuel Sierra; Lucı́a, Alejandro

doi:10.1136/bjsports-2012-091892

Cited by 51 publications

(97 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Further, special ‘in-room’ exercise interventions (e.g., including light weightlifting while lying in bed) are effective and feasible in isolated, highly immunocompromised children during inpatient hospitalization for pediatric allo-HSCT (98). Finally, other special and simple interventions such as specific inspiratory load training to improve the function of breathing musculature with special, small size breathing devices (e.g., ‘Power breathe’) are easily applicable even in patients’ homes, as we have shown in children with cystic fibrosis (121). In the above mentioned fragile populations, besides the almost unanimous benefits in aerobic capacity or muscle strength, in some patient populations the exercise interventions also produced improvements in: (i) the individuals’ ability to cope independently with daily living (e.g., decreased risk of falls in nonagenarians (118) or improved performance in functional tests in children who had received allo/haploidentical HSCT) (122); or (ii) self-reported QoL, e.g., improved self-report of comfort and resilience in pediatric patients who had undergone HSCT (122).…”

Section: From Preclinical Studies To Clinical Trials: Suggested Feasimentioning

confidence: 96%

Physical function and quality of life in patients with chronic GvHD: a summary of preclinical and clinical studies and a call for exercise intervention trials in patients

Fiuza‐Luces

Simpson

Ramı́rez

et al. 2015

Bone Marrow Transplant

View full text Add to dashboard Cite

Allogeneic Hematopoietic Stem Cell Transplant, to reconstitute hematopoietic and immune status of patients undergoing myeloablative therapy for hematologic disorders, has been of great benefit in minimizing or eradicating disease and extending survival. Patients who undergo allogeneic hematopoietic stem cell transplant (allo-HSCT) are subject to many comorbidities among which the most significant, affecting quality of life (QoL) and survival, are acute (aGVHD) and chronic Graft Versus Host Disease (cGVHD), resulting from donor lymphocytes reacting to and damaging host tissues. Physical activity and exercise have clearly been shown, in both children and adults, to enhance fitness, improve symptomatology and QoL, reduce disease progression and extend survival for many diseases including malignancies. In some cases, vigorous exercise has been shown to be equal to or more effective than pharmacologic therapy. This review addresses how cGVHD affects patients’ physical function and physical domain of QoL, and the potential benefits of exercise interventions along with recommendations for relevant research and evaluation targeted at incorporating this strategy as soon as possible after allo-HSCT and ideally, as soon as possible upon diagnosis of the condition leading to allo-HSCT.

show abstract

Section: From Preclinical Studies To Clinical Trials: Suggested Feasimentioning

confidence: 96%

Physical function and quality of life in patients with chronic GvHD: a summary of preclinical and clinical studies and a call for exercise intervention trials in patients

Fiuza‐Luces

Simpson

Ramı́rez

et al. 2015

Bone Marrow Transplant

View full text Add to dashboard Cite

show abstract

“…[10][11][12][13][14][15] Inspiratory muscle training has been shown to improve cycling endurance, exercising lactate levels, diaphragm thickness, and inspiratory muscle strength in previous studies. [34][35][36][37][38][39] Findings in the literature serve as possible explanations for the large improvement in exercise capacity. In the literature, we also noted descriptions of the effects of inspiratory muscle training on maximal exercise capacity; modified incremental shuttle walk test distance improved (45.4 m) with remarkably large effect sizes in subjects with sarcoidosis after inspiratory muscle training.…”

Section: Functional and Maximal Exercise Capacitymentioning

confidence: 99%

“…Combined aerobic, resistance training, and inspiratory muscle training resulted in improved peripheral muscle strength compared with aerobic training in subjects with chronic heart failure and cystic fibrosis. 37,38 Whether the application of higher intensity and/or longer duration training or a combination of inspiratory muscle training with aerobic/resistance training might provide a treatment effect on peripheral muscle strength in recipients should be investigated.…”

Section: Peripheral Muscle Strengthmentioning

confidence: 99%

Effects of Inspiratory Muscle Training in Subjects With Sarcoidosis: A Randomized Controlled Clinical Trial

Karadalli¹,

Boşnak-Güçlü²,

Camcıoğlu³

et al. 2015

Respir Care

View full text Add to dashboard Cite

BACKGROUND: Respiratory muscle weakness occurs in sarcoidosis and is related to decreased exercise capacity, greater fatigue, dyspnea, and lower quality of life in sarcoidosis patients. The effects of inspiratory muscle training in this population have not been comprehensively investigated so far. This study was planned to investigate the effects of inspiratory muscle training on exercise capacity, respiratory and peripheral muscle strength, pulmonary function and diffusing capacity, fatigue, dyspnea, depression, and quality of life in subjects with sarcoidosis. METHODS: This was a prospective, randomized, controlled, and double blind study. Fifteen sarcoidosis subjects (treatment group) received inspiratory muscle training at 40% of maximal inspiratory pressure (P Imax ), and 15 subjects (control group) received sham therapy (5% of P Imax ) for 6 weeks. Functional and maximal exercise capacity, respiratory and peripheral muscle strength, pulmonary function and diffusing capacity, fatigue, dyspnea, depression, and quality of life were evaluated. RESULTS: Functional (P < .001) and maximal exercise capacity (P ‫؍‬ .038), respiratory muscle strength (P Imax [P < .001] and P Emax [P ‫؍‬ .001]), severe fatigue (P ‫؍‬ .002), and dyspnea perception (P ‫؍‬ .02) were statistically significantly improved in the treatment group compared with controls; no significant improvements were observed in pulmonary function and diffusing capacity, peripheral muscle strength, fatigue, depression, and quality of life between groups after inspiratory muscle training. CONCLUSIONS: Inspiratory muscle training improves functional and maximal exercise capacity and respiratory muscle strength and decreases severe fatigue and dyspnea perception in subjects with early stages of sarcoidosis. Inspiratory muscle training can be safely and effectively included in rehabilitation programs. (ClinicalTrials.gov registration NCT02270333.)

show abstract

“…However, the authors found no such improvement in lung flows and volumes, and they suggested that their results be confirmed in studies with a higher level of methodological quality. ( 7 ) Santana-Sosa et al ( 25 ) observed that RMT combined with general muscle training had beneficial effects for respiratory muscle strength and physical conditioning in children with cystic fibrosis. ( 25 ) In the CLD group, there was an overall post-RMT increase in respiratory muscle strength (i.e., MIP and MEP) of 33%, the greatest improvement being observed in our cystic fibrosis patients, who showed increases of 30 cmH 2 O (42%) and 25 cmH 2 O (45%) in MIP and MEP, respectively.…”

Section: Discussionmentioning

confidence: 99%

Effects of home-based respiratory muscle training in children and adolescents with chronic lung disease

2014

View full text Add to dashboard Cite

OBJECTIVE: Respiratory muscle weakness is a functional repercussion of chronic lung disease (CLD). The objective of this study was to assess the effects of home-based respiratory muscle training (RMT) in children and adolescents with CLD or neuromuscular disease (NMD). METHODS: This was a quasi-experimental study involving children and adolescents with CLD or NMD. Before and after 6 months of home-based RMT, we measured respiratory muscle strength (MIP and MEP), PEF, and peak cough flow (PCF). We made statistical comparisons between the pre-RMT and post-RMT values, as well as evaluating the correlation between the duration and effect of RMT. RESULTS: The study included 29 patients, with a mean age of 12 years (range, 5-17 years), of whom 18 (62.1%) were male. The CLD group comprised 11 patients (37.9%), and the NMD group comprised 18 (62.1%). The mean duration of the RMT was 60 weeks (range, 46-90 weeks) in the CLD group and 39 weeks (range, 24-89 weeks) in the NMD group. In comparison with the pre-RMT values, the post-RMT values for MIP and MEP were significantly higher in both groups, whereas those for PEF and PCF were significantly higher only in the NMD group. We found no correlation between the duration and the effect of RMT. CONCLUSIONS: Home-based RMT appears to be an effective strategy for increasing respiratory muscle strength in children and adolescents with CLD or NMD, although it increased the ability to cough effectively only in those with NMD.

show abstract

Benefits of combining inspiratory muscle with ‘whole muscle’ training in children with cystic fibrosis: a randomised controlled trial

Cited by 51 publications

References 30 publications

Physical function and quality of life in patients with chronic GvHD: a summary of preclinical and clinical studies and a call for exercise intervention trials in patients

Physical function and quality of life in patients with chronic GvHD: a summary of preclinical and clinical studies and a call for exercise intervention trials in patients

Effects of Inspiratory Muscle Training in Subjects With Sarcoidosis: A Randomized Controlled Clinical Trial

Effects of home-based respiratory muscle training in children and adolescents with chronic lung disease

Contact Info

Product

Resources

About