Parental Consanguinity and Nonsyndromic Orofacial Clefts in Children: A Systematic Review and Meta-Analyses

Sabbagh, Heba Jafar; Hassan, Mona Hassan Ahmed; Innes, Nicola; Baik, Alaa Al; Mossey, Peter

doi:10.1597/12-209

Cited by 28 publications

(39 citation statements)

References 41 publications

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“…[5,16] A statistically significant association (P = 0.04) was seen with consanguinity and CP. Similar significant results were reported between consanguinity and OFC, [6,13,15,16,18] whereas Golalipour et al reported that no significant association was seen between consanguinity and OFC. [28] This significance could indicate the biological plausibility between consanguinity and OFC, particularly CP.…”

Section: Discussionsupporting

confidence: 67%

“…[28] This significance could indicate the biological plausibility between consanguinity and OFC, particularly CP. This significance is explained by other studies considering factors such as degree of consanguinity, [18] ascertainment, [6] family history of clefts, and intracluster correlation between siblings affected by OFC. [16] Consanguineous marriages have been debated since Darwinian times.…”

Section: Discussionmentioning

confidence: 98%

“…[5] A meta-analysis revealed an odds ratio of 1.83 (95% confidence interval, 1.31-2.54) implying the risk of having cleft two times higher in children with consanguineous history. [6] Consanguineous marriages are a common social norm in many societies worldwide where marriages are between close blood-related persons varying from first cousins to uncle-niece relations. About 10.4% of couples in the global population are reported to be related as the second cousins or closer; a similar relationship holds true for the progeny of these couples.…”

Section: Introductionmentioning

confidence: 99%

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The relationship between orofacial clefts and consanguineous marriages: A hospital register-based study in Dharwad, South India

Rajeev

Prasad

Shetty

et al. 2017

J Cleft Lip Palate Craniofac Anomal

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This is the published version of a paper published in .Citation for the original published paper (version of record):Rajeev, B., Prasad, K., Shetty, P J., Preet, R. (2017) The relationship between orofacial clefts and consanguineous marriages: A hospital registerbased study in Dharwad, South India. There is a lack of literature reporting the number of people affected with OFCs due to consanguinity. Aims: The aim of this study is to report the occurrence of OFC and associated factors in relation to consanguinity from a craniofacial hospital specializing in OFCs, head and neck cancer, and trauma management in South India. Setting and Design: This was a hospital-based study, retrospective case record analysis. Methodology: One thousand two hundred and forty-seven consecutive patients' secondary data records with cleft lip (CL), cleft palate (CP) and cleft lip and palate (CL/P) were collected from January 2007 to July 2009. Statistics: Frequency of consanguinity in relation to OFC was analyzed using Chi-square test according to the nature of clefts and selected demographic features such as sex, region, and religion. Results: A total of 47.2% patients' parents had consanguineous marriage. Consanguinity was seen in 60.2% of male and 39.7% of female patients. CL/P was noticed in 40.9%, followed by CL (36.7%) and CP (22.2%). Males predominated in all types of clefts proportionally with the study population as compared to females. Statistically, significant association (P = 0.04) was seen with consanguinity and CP. Conclusion: Nearly half of the study population had a positive history of consanguinity. Statistically, a significant association was seen between CP and consanguinity. CL/P cases were the most common type identified, followed by CL and CP. Males predominated in all types of clefts. The Access this article online Website: www.jclpca.org

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Section: Discussionsupporting

confidence: 67%

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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The relationship between orofacial clefts and consanguineous marriages: A hospital register-based study in Dharwad, South India

Rajeev

Prasad

Shetty

et al. 2017

J Cleft Lip Palate Craniofac Anomal

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“…A number of factors are known to affect the prevalence orofacial clefts, including genetic factors such as ethnicity and family history of clefting, as well as environmental factors such as maternal smoking and in-utero exposure to seizure medications (Hill et al 1988, Kallen 2003, Mossey et al 2009, Kucik et al 2012, Lie, Wilcox, and Skjaerven 2001, Sabbagh et al 2014. There is some evidence for deprivation being a risk factor for clefting, however the precise elements of deprivation, and underlying mechanism remains poorly understood (Durning et al 2007, Clark et al 2003.…”

Section: Discussionmentioning

confidence: 99%

Systematic Review and Meta-Analysis of the Birth Prevalence of Orofacial Clefts in Low- and Middle-Income Countries

Kadir

Mossey

Blencowe

et al. 2017

The Cleft Palate-Craniofacial Journal

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In LMICs, approximately 1 in every 730 children is born with CL/P. To optimize comparability across settings, future research should use a standard classification system and standard criteria for data collection and presentation. As clefting is associated with deprivation, understanding the true scale, risks, and preventive measures for orofacial clefts in LMIC is a matter of both scientific and humanitarian importance.

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“…There are several studies suggesting that consanguinity is a risk factor for orofacial cleft, particularly from Saudi Arabia [24,25]. Such findings may suggest the role of genetic etiology, which necessitate the need for genetic analysis.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Incidence of Orofacial Cleft Anomalies in Children with Cleft Lip and Palate Associated with Etiological Deformities in Hail Region, Saudi Arabia

Faraj AlShammari,

Habib AlShammary,

Rasheed Alshubrmi

et al. 2017

IJDSR

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Aim: The aim of this study was to explore the prevalence, incidence and possible etiological risk factors of orofacial cleft in Hail Region, Northern Saudi Arabia. Methodology: This is a retrospective study conducted in Maternity Hospital, Hail, Saudi Arabia. Data of seven years (2011-2017) records of newborn infants were reviewed for the presence of orofacial anomalies (included 27800 files). Results: The overall prevalence rate of orofacial cleft was 1.08 per 1000 births. Out of 30 patients diagnosed with orofacial anomalies, 14(46.7%) were found with cleft palate, 11(36.7%) with bilateral cleft lip and palate, 4(13.3%) with bilateral cleft lip and only one (3.3%) with unilateral cleft lip and palate. Conclusion: The prevalence of orofacial clefts in Northern Saudi Arabia was similar or slightly lower than the higher global reported rates. Cleft palate was the most common type of orofacial cleft in Northern Saudi Arabia.

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Parental Consanguinity and Nonsyndromic Orofacial Clefts in Children: A Systematic Review and Meta-Analyses

Cited by 28 publications

References 41 publications

The relationship between orofacial clefts and consanguineous marriages: A hospital register-based study in Dharwad, South India

The relationship between orofacial clefts and consanguineous marriages: A hospital register-based study in Dharwad, South India

Systematic Review and Meta-Analysis of the Birth Prevalence of Orofacial Clefts in Low- and Middle-Income Countries

Prevalence and Incidence of Orofacial Cleft Anomalies in Children with Cleft Lip and Palate Associated with Etiological Deformities in Hail Region, Saudi Arabia

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