Curiethérapie exclusive du cancer de la prostate par implants permanents : indications et résultats. Revue du CC-AFU

Construction of multifunctional organic–inorganic hybrid Bi2S3–PLGA capsules for highly efficient ultrasound-guided radiosensitization of brachytherapy

“…Based on the tumor growth curve and the analysis of Ki67 of tumor cells, it can be concluded that the fabricated Bi 2 S 3 -PLGA capsules can function as the efficient in vivo radiation sensitizer for enhancing the therapeutic efficiency of brachytherapy. In addition, the in situ intratumor administration was adopted because brachytherapy typically implants the radiation source into the tumor clinically, [1][2][3][4] which can maximally accumulate the Bi 2 S 3 -PLGA capsules and P-32 radiation source within the tumors. Thus, the administration dose can be much lower than traditional systemic administration, such as intravenous injection, causing the signicantly reduced toxicities to mice.…”

“…Brachytherapy has been widely used as an efficient therapeutic modality against prostate carcinoma due to its unique advantage of long-term and durable radiation effect by placing the radiation source directly inside the tumor. [1][2][3][4] The implanted radiation source, containing different formations, such as colloids, seeds, and containers, can deliver a signicantly higher radiation dose to the prostate carcinoma with mitigated side-effects to the surrounding normal tissues compared to the traditional external radiation therapy. To increase the accuracy of radiation source placement and ensure that the tumor can receive efficient concentration and distribution of seeds throughout the prostate tumor, the in situ ultrasound imaging was generally applied, by which the catheter can be monitored to guide the implanting process.…”

Suivi après radiothérapie des cancers de prostate : évaluation et prise en charge de la toxicité et de la récidive

“…Après une opération, la radiothérapie entraîne le même taux de complications urinaires à long terme [25]. La curiethérapie expose à un risque majoré de sténose de l'urètre dans près de 5 à 15 % des cas, voire à d'exceptionnelle fistule [26]. L'International Prostate Symptom Score (IPSS) est le facteur le plus prédictif de toxicité urinaire aiguë [27].…”