Oncological and functional results of robotic salvage radical prostatectomy after permanent brachytherapy implants

Orré, M.; Piéchaud, Thierry; Sargos, P.; Richaud, Pierre; Roubaud, Guilhem; Thomas, Laurence

doi:10.1016/j.canrad.2016.11.001

Cited by 9 publications

(7 citation statements)

References 25 publications

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“…As IMRT made radiation field reduction on the peri‐prostate and reduction in fibrotic change and adhesion around the prostate tissue possible, we neither had any difficulty performing RARC nor observed any postoperative complications. Although not many case series of salvage RARP after brachytherapy or proton therapy were reported, several studies suggested feasible outcomes in complications and functional outcomes . Moreover, the patient achieved QOL improvement 6 months following RARC in the global, physical, cognitive, emotional, social nausea, sleep, appetite loss, and constipation.…”

Section: Discussionmentioning

confidence: 97%

“…However, a previous study that investigated the safety of RARC in patients with previous history of pelvic irradiation concluded that complication rates were not differ between the patients with and without pelvic radiation . In addition, recent study for salvage RARP after radiation therapy suggested low complications rates including rectal injuries (<2%) . A robotic procedure can overcome the difficulty of separation between the prostate and rectum.…”

Section: Discussionmentioning

confidence: 99%

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Robot‐assisted radical cystectomy in a patient with muscle‐invasive bladder cancer following radiotherapy for prostate cancer

et al. 2019

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Abbreviations & Acronyms GCb = gemcitabine plus carboplatin IMRT = intensity-modulated radiation therapy MIBC = muscle-invasive bladder cancer NAC = neoadjuvant chemotherapy PC = prostate cancer POD = postoperative day QOL = quality of life RARC = robot-assisted radical cystectomy RARP = robotic-assisted radical prostatectomy RC = radical cystectomy RT = radiotherapy Correspondence: ShingoIntroduction: Muscle-invasive bladder cancer following radiotherapy for prostate cancer is rare. We reported a case of muscle-invasive bladder cancer who underwent robot-assisted radical cystectomy following radiotherapy for prostate cancer. Case presentation: A 72-year-old man was referred to our division with a muscleinvasive bladder cancer. He had a history of intensity-modulated radiation therapy for localized prostate cancer. After three courses of platinum-based neoadjuvant chemotherapy, he obtained a radiologic complete response. He elected for robotassisted radical cystectomy, standard lymph node dissection, and intracorporeal ileal conduit urinary diversion. Pathological findings revealed no residual tumor within the bladder and residual tumor in the prostate. He had discharged without any complications; and quality of life had improved. Conclusion: A robot-assisted approach might be a potential option for well-selected patients with muscle-invasive bladder cancer who have previously received radiotherapy for localized prostate cancer.Although surgical treatment for patients with MIBC who have previously received RT for PC is challenging, this report indicates a robot-assisted approach might be a potential option for well-selected patients with MIBC who have previously received RT for localized PC.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Robot‐assisted radical cystectomy in a patient with muscle‐invasive bladder cancer following radiotherapy for prostate cancer

et al. 2019

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“…The follow-up in the current series is relatively short after sRP, however considering these patients are very-high risk populations, failures are more likely to occur soon after local therapy. The advantage of using robotic platform in this cohort of complex operations needs to be further explored [ 16 17 ]. Overall, it is important to reemphasize the complexity of sRP following multiple local treatments; while cancer control appears excellent this must be balanced by concerns of surgical morbidity.…”

Section: Discussionmentioning

confidence: 99%

Outcomes of salvage radical prostatectomy following more than one failed local therapy

2018

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PurposeTo describe the salvage radical prostatectomy (sRP) experience in patients presenting with recurrent, clinically localized prostate cancer after multiple failed local treatments.Materials and MethodsAmong the 251 sRP performed during 2000–2016, 11 patients had failed multiple local therapies. We describe baseline clinical characteristics at primary cancer diagnosis and prior to sRP, surgical information, complications and oncological outcomes.ResultsThe mean±standard deviation age at sRP was 65±5 years and the median (interquartile range) serum prostate-specific antigen (PSA) level was 2 (1.3) ng/mL. The most common first and subsequent treatments were radiotherapy and cryotherapy, respectively, with median time of 24 months from the last local treatment. The median operative time was 180 minutes and median estimated blood loss was 750 mL. Five (45.5%) patients underwent additional procedures during sRP for pre-operative morbidity from prior treatments (rectourethral fistula, urethral stricture, incontinence). Post-operative complications requiring invasive intervention occurred in 7 (63.6%) patients. Over a median follow-up of 29 (12–96) months, 10 of the 11 men (90.9%) achieved an undetectable PSA in after sRP. Three of these men with an initially undetectable PSA level experienced biochemical recurrence; the remaining 7 are without evidence of disease. Overall, no local recurrence or systemic metastasis was identified at last follow-up.ConclusionssRP is technically feasible and offers durable cancer control in patients with recurrent prostate cancer despite having undergone multiple prior attempts at cure. These patients experience higher rates of post-operative complications and such patients must be appropriately counseled regarding the potential risks and benefits.

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“…Median age at the time of RP was 65 years (IQR: 61-67). Median prostatic volume before VTP was 35 mL (30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46). Median PSA before RP was 5.9 (3.2-7.9) ng/mL.…”

Section: A N U S C R I P Tmentioning

confidence: 99%

“…A C C E P T E D ACCEPTED MANUSCRIPT 22 RALP vs RRP (n=315) <1 pad changed per/d No pad 84% 72% Wallerstedt et al 28 , RALP vs RRP (n=1360) No Pad 66% Haglind et al 24 , RALP VS RRP (n=2431) <1 pad 79 % Donovan et al 29 RRP/RALP/LRP (n=553) <1 pad/day 70% Salvage Prostatectomy Leonardo et al 9 LRP (n=13) after HIFU No pad 69% Lawrentschuk et al 13 RRP (n=15) after HIFU No pad 60% Orré et al 30 RARP (n=7) after brachytherapy No pad 57% Linares Espinos et al 23 LRP/RARP (n=12/16) after ERBT (n=6), brachytherapy (n=3) VTP (n=1), HIFU (n=6), cryotherapy…”

Section: A N U S C R I P Tmentioning

confidence: 99%

Radical Prostatectomy after Vascular Targeted Photodynamic Therapy with Padeliporfin: Feasibility, and Early and Intermediate Results

et al. 2019

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Oncological and functional results of robotic salvage radical prostatectomy after permanent brachytherapy implants

Cited by 9 publications

References 25 publications

Robot‐assisted radical cystectomy in a patient with muscle‐invasive bladder cancer following radiotherapy for prostate cancer

Robot‐assisted radical cystectomy in a patient with muscle‐invasive bladder cancer following radiotherapy for prostate cancer

Outcomes of salvage radical prostatectomy following more than one failed local therapy

Radical Prostatectomy after Vascular Targeted Photodynamic Therapy with Padeliporfin: Feasibility, and Early and Intermediate Results

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