Diffusion of ionic and non-ionic contrast agents in articular cartilage with increased cross-linking—Contribution of steric and electrostatic effects

Kulmala, K.A.M.; Karjalainen, Hannu M.; Kokkonen, Harri; Tiitu, Virpi; Kovanen, Vuokko; Jurvelin, Jukka S.; Korhonen, Rami K.; Töyräs, Juha

doi:10.1016/j.medengphy.2013.03.010

Cited by 23 publications

(24 citation statements)

References 45 publications

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“…cruciate) ligament evaluation [89, [94][95][96]. The resulting contrast-enhanced CT attenuation reflect the mechanical and biochemical properties of the tissue [20,[97][98][99] and the technique can be translated to a clinical scanner [100]. Anionic agents diffuse into cartilage inversely to the fixed charge density in the extracellular matrix as determined with microCT.…”

Section: Techniques/usesmentioning

confidence: 99%

Use of contrast media in computed tomography and magnetic resonance imaging in horses: Techniques, adverse events and opportunities

Nelson

Goodrich

Barrett

et al. 2017

Equine Veterinary Journal

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The use of contrast media in computed tomography (CT) and magnetic resonance imaging (MRI) is increasing in horses. These contrast-enhanced imaging techniques provide improved tissue delineation and evaluation, thereby expanding diagnostic capabilities. While generally considered safe, not all contrast media exhibit the same safety profiles. The safety of contrast media use and descriptions of adverse events occurring in horses are sparsely reported. This review summarises the reported evidence of contrast media use and adverse events that occur in horses, with added contribution from other veterinary species and studies in man for comparison. This comprehensive data set empowers equine clinicians to develop use and monitoring strategies when working with contrast media. Finally, it summarises the current state-of-the-art and highlights the potential applications of contrast-enhanced CT and MRI for assessment of diseased or injured equine tissues, as well as (patho)physiological processes.

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Section: Techniques/usesmentioning

confidence: 99%

Use of contrast media in computed tomography and magnetic resonance imaging in horses: Techniques, adverse events and opportunities

Nelson

Goodrich

Barrett

et al. 2017

Equine Veterinary Journal

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“…From these sections, the water content was determined with the freeze drying method 29 . Subsequently, hydroxyproline and uronic acid contents, which correspond to the collagen and PG contents respectively, were determined.…”

Section: Histology and Compositional Analysesmentioning

confidence: 99%

Contrast enhanced imaging of human meniscus using cone beam CT

Honkanen

Danso

Suomalainen

et al. 2015

Osteoarthritis and Cartilage

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“…16,17 Intact bovine patellae (n ¼ 14) were obtained from a local abattoir (Atria Oyj, Kuopio, Finland). Ethical approval was not required, as the animals were not slaughtered for the purposes of this study.…”

Section: Sample Preparationmentioning

confidence: 99%

“…16,17,26 Briefly, the amount of the collagen specific amino acid, hydroxyproline, was measured spectrophotometrically to estimate the total amount of collagen. 27 HPLC was used to separate hydroxylysyl pyridinoline (HP), lysyl pyridinoline (LP), and pentosidine (Pent).…”

Section: Biochemical Analysismentioning

confidence: 99%

Infrared microspectroscopic determination of collagen cross-links in articular cartilage

et al. 2017

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, "Infrared microspectroscopic determination of collagen cross-links in articular cartilage," J. Biomed. Opt. 22(3), 035007 (2017), doi: 10.1117/1.JBO.22.3.035007. Abstract. Collagen forms an organized network in articular cartilage to give tensile stiffness to the tissue. Due to its long half-life, collagen is susceptible to cross-links caused by advanced glycation end-products. The current standard method for determination of cross-link concentrations in tissues is the destructive high-performance liquid chromatography (HPLC). The aim of this study was to analyze the cross-link concentrations nondestructively from standard unstained histological articular cartilage sections by using Fourier transform infrared (FTIR) microspectroscopy. Half of the bovine articular cartilage samples (n ¼ 27) were treated with threose to increase the collagen cross-linking while the other half (n ¼ 27) served as a control group. Partial least squares (PLS) regression with variable selection algorithms was used to predict the cross-link concentrations from the measured average FTIR spectra of the samples, and HPLC was used as the reference method for cross-link concentrations. The correlation coefficients between the PLS regression models and the biochemical reference values were r ¼ 0.84 (p < 0.001), r ¼ 0.87 (p < 0.001) and r ¼ 0.92 (p < 0.001) for hydroxylysyl pyridinoline (HP), lysyl pyridinoline (LP), and pentosidine (Pent) cross-links, respectively. The study demonstrated that FTIR microspectroscopy is a feasible method for investigating cross-link concentrations in articular cartilage.

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Diffusion of ionic and non-ionic contrast agents in articular cartilage with increased cross-linking—Contribution of steric and electrostatic effects

Cited by 23 publications

References 45 publications

Use of contrast media in computed tomography and magnetic resonance imaging in horses: Techniques, adverse events and opportunities

Use of contrast media in computed tomography and magnetic resonance imaging in horses: Techniques, adverse events and opportunities

Contrast enhanced imaging of human meniscus using cone beam CT

Infrared microspectroscopic determination of collagen cross-links in articular cartilage

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