Multi-residue method for determination of selected neonicotinoid insecticides in honey using optimized dispersive liquid–liquid microextraction combined with liquid chromatography-tandem mass spectrometry

Jovanov, Pavle; Guzsvány, Valéria; Franko, Mladen; Lazić, Sanja; Sakač, Marijana; Šarić, Bojana; Banjac, Vojislav

doi:10.1016/j.talanta.2013.02.059

Cited by 125 publications

(68 citation statements)

References 48 publications

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“…The percentage of positive samples is, to some extent, correlated with the detection limits (table S7). For example, in a British study (26), 16 out of 22 samples were positive for clothianidin, but for all of these samples the measured concentrations (>0.02 to 0.82 ng/g) were below the detection limit of a Serbian study (1.0 ng/g) in which no sample tested positive (33). With the improvement of analytical methods, we can therefore expect that the proportion of positive samples will increase.…”

mentioning

confidence: 98%

A worldwide survey of neonicotinoids in honey

Mitchell

Mulhauser²,

Mulot

et al. 2017

Science

382

251

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Growing evidence for global pollinator decline is causing concern for biodiversity conservation and ecosystem services maintenance. Neonicotinoid pesticides have been identified or suspected as a key factor responsible for this decline. We assessed the global exposure of pollinators to neonicotinoids by analyzing 198 honey samples from across the world. We found at least one of five tested compounds (acetamiprid, clothianidin, imidacloprid, thiacloprid, and thiamethoxam) in 75% of all samples, 45% of samples contained two or more of these compounds, and 10% contained four or five. Our results confirm the exposure of bees to neonicotinoids in their food throughout the world. The coexistence of neonicotinoids and other pesticides may increase harm to pollinators. However, the concentrations detected are below the maximum residue level authorized for human consumption (average ± standard error for positive samples: 1.8 ± 0.56 nanograms per gram).

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mentioning

confidence: 98%

A worldwide survey of neonicotinoids in honey

Mitchell

Mulhauser²,

Mulot

et al. 2017

Science

382

251

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“…Since the invention of DLLME technology in 2006 [21], there has been a growing number of publications focused on this extraction technique, including original articles and reviews [22][23][24][25][26][27][28][29][30][31][32].…”

Section: Original Studymentioning

confidence: 99%

Evaluation of dispersive liquid-liquid microextraction for the determination of cobalt and cadmium by flame atomic absorption spectrometry: application in water and food samples

Ojeda¹,

Rojas²

2014

Sample Preparation

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Dispersive liquid-liquid microextraction (DLLME) was applied to the separation and preconcentration of Cd(II) and Co(II) from water and food samples. The influence of the following analytical parameters on the quantitative recoveries of cadmium and cobalt were investigated: pH, extraction solvent volume, dispersing solvent volume and type, and concentration of chelating agent. Under the optimized conditions, the detection limits were 2 μg L

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“…To our best knowledge, no rapid method of analysis of up to 132 insecticides belonging to 29 chemical classes in honey samples, using QuEChERS/LC-MS/MS has been described in the literature. Works available in the literature describe methods that make it possible to determine individual groups of insecticides: benzoylurea (Wang et al 2016), neonicotinoids (Gbylik-Sikorska et al 2015;Jovanov et al 2013Jovanov et al , 2014, organochlorines (Zacharis et al 2012), pyrethroids (Li et al 2013), organophosphorus (Naggar et al 2015;Blasco et al 2004), or several groups of insecticides, but never so many. For instance, Paradis et al (2014) reported the simultaneous determination of 22 insecticides of three chemical classes in honey.…”

Section: Introductionmentioning

confidence: 99%

Liquid Chromatographic MS/MS Analysis of a Large Group of Insecticides in Honey by Modified QuEChERS

2018

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The analytical tool for analysis of pesticide residues in honey must still be improved. Therefore, a sensitive, selective, rapid, and reliable analytical method for the analysis of pesticide residue belonging to 29 different classes at very low concentration levels was developed. Over 130 insecticides were extracted from the honey matrix using different amounts of sample, concentrations of the extraction solvent, and cleanup sorbents. Acceptable extraction recoveries accounting for matrix effect were obtained using the cleanup sorbent combination chitosan/aluminum oxide/C8 (200/200/200 mg) and 1% FA in ACN. Determinations were made by liquid chromatography-tandem mass spectrometry (LC-MS/MS). For most compounds, the recoveries range from 70 to 120%, with relative standard deviations < 20%. Linear correlation coefficients (r2) were higher than 0.99 at concentration levels of 0.001-0.100 mg kg−1. A positive matrix effect was observed for up to 95% of organophosphates and 43% of pyrethroids and a negative effect for 37% of neonicotinoids. This work showed that the presented method is convenient and reliable for quick monitoring of insecticides in honey samples.

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Multi-residue method for determination of selected neonicotinoid insecticides in honey using optimized dispersive liquid–liquid microextraction combined with liquid chromatography-tandem mass spectrometry

Cited by 125 publications

References 48 publications

A worldwide survey of neonicotinoids in honey

A worldwide survey of neonicotinoids in honey

Evaluation of dispersive liquid-liquid microextraction for the determination of cobalt and cadmium by flame atomic absorption spectrometry: application in water and food samples

Liquid Chromatographic MS/MS Analysis of a Large Group of Insecticides in Honey by Modified QuEChERS

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