Oral<i>Huangqi</i>Formulae for Stable Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis

Wu, Lei; Chen, Yuanbin; Xu, Yinji; Guo, Xinfeng; Li, Xiaoyan; Zhang, Anthony Lin; May, Brian H.; Xue, Charlie Changli; Wen, Zehuai; Lin, Lin

doi:10.1155/2013/705315

Cited by 15 publications

(17 citation statements)

References 15 publications

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“…Using Chinese medicines or integrated Chinese and Western medicines to treat stable COPD has significant efficacy [6], improving pulmonary function and increasing diaphragm muscular tension [7]. A large amount of high-quality and high-level evidence has shown that its efficacy in improving symptoms, reducing exacerbations, and improving exercise capacity and quality of life is better than treatment with Western medicines alone [8–10]. …”

Section: Introductionmentioning

confidence: 99%

Effect of Radix Stemonae concentrated decoction on the lung tissue pathology and inflammatory mediators in COPD rats

Wang

Yang

et al. 2016

BMC Complement Altern Med

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BackgroundChronic obstructive pulmonary disease (COPD) is a common and frequently occurring respiratory disease. At present, western medicine treatment of COPD mainly focuses on symptomatic treatment. Using Chinese medicines or integrated Chinese and Western medicines to treat stable COPD has significant efficacy. In this study, we aimed to observe the effect of Radix Stemonae concentrated decoction on the lung tissue pathology and inflammatory mediators in COPD rats and explore its possible mechanism.MethodsSD rats were randomized into blank group, COPD model group and Radix Stemonae group, 10 cases in each group. Rats were fed for 112 days. Before the rats were sacrificed, lung function of the animals was tested. The right lower lung was fixed for morphologic observation. The inflammatory mediators in serum were determined using enzyme-linked immuno sorbent assay.ResultsBody weight of animals in the model group was significantly decreased compared with blank group (P < 0.05). After gavage therapy with Radix Stemonae, body weight was significantly increased (P < 0.05). Compared with the blank group, pulmonary functions of rats in the model group were significantly abnormal (P < 0.05), while in Radix Stemonae group, these indicators turned much better than model group (P < 0.05). As for pathological changes in lungs, airway inflammation in the model group was aggravated. In the Radix Stemonae group, inflammation and emphysema were much milder. The concentrations of TNF-α, IL-8 and LTB4 in both model group and Radix Stemonae group were increased significantly (P < 0.05). But the levels in Radix Stemonae group were decreased significantly than model group (P < 0.05).ConclusionRadix Stemonae concentrated decoction may mitigate and improve airway rebuilding in the lungs of COPD rats by inhibiting the release of inflammatory mediators.

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Section: Introductionmentioning

confidence: 99%

Effect of Radix Stemonae concentrated decoction on the lung tissue pathology and inflammatory mediators in COPD rats

Wang

Yang

et al. 2016

BMC Complement Altern Med

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“…The detailed method followed the reported one [ 44 ]. Two reviewers (Shanshan Wang and Jinfeng Zhang) independently extracted data.…”

Section: Methodsmentioning

confidence: 99%

The Efficacy of Shen Shuaining Capsule on Chronic Kidney Disease: A Systematic Review and Meta‐Analysis

Wang

Zhang

Guo

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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Objective. To evaluate the efficacy of Shen shuaining capsule on treating chronic kidney disease (CKD). Methods. All randomized controlled trials (RCTs) of Shen shuaining capsule in treating CKD were collected from CBM, CNKI, VIP, Wanfang, EMBASE, MEDLINE, PubMed, and Cochrane library clinical controlled trials database. Two reviewers independently performed analysis of the included trials according to the inclusion and exclusion criteria. The risk of bias tool was from the Cochrane Handbook version 5.1.0. The Review Manager 5.2 software was employed for data analysis. Funnel plot and Egger's test were applied to evaluate publication bias. Results. 20 studies including 1606 participants met the inclusion criteria, most of which were of low quality. Meta-analysis indicated that Shen shuaining capsule was effective for CKD in terms of SCR, BUN, Hb, and response rate and with less adverse effects, of which SCR and BUN decreased significantly (MD = −84.72, 95% CI: −107.36, −62.07, P < 0.00001) (MD = −4.30, 95% CI: −5.71, −2.89, P < 0.00001); Hb and response rate increased significantly (MD = 9.94, 95% CI: 9.24, 10.64, P < 0.00001) (OR = 4.25, 95% CI (3.32, 5.42), P < 0.00001). Conclusion. Shen shuaining capsule significantly reduced SCR and BUN, increased HB, and improved total efficiency of the symptoms and signs in patients with CKD. Subgroup analysis found that Shen shuaining capsule group was better than control group. Due to low quality of the methodology of included studies, further high-quality researches were needed to study its efficacy and safety.

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“…As a highly potent herb widely used to treat various diseases, AR has played an indispensable role in healthcare throughout Chinese history [1,2]. Traditionally, AR is used for the treatment of anemia, weakness, fever, wounds, chronic fatigue, multiple allergies, loss of appetite, uterine bleeding and uterine prolapse [3,4,5]. Modern pharmacological studies and clinical practices indicate that AR and its main active ingredients possess various biological properties and are widely used to treat cardiovascular diseases, diabetes mellitus, cancer, respiratory diseases and nervous system diseases [8].…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

A Systematic Review of Phytochemistry, Pharmacology and Pharmacokinetics on Astragali Radix: Implications for Astragali Radix as a Personalized Medicine

Guo

Lou

Kong

et al. 2019

IJMS

100

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Astragali radix (AR) is one of the most widely used traditional Chinese herbal medicines. Modern pharmacological studies and clinical practices indicate that AR possesses various biological functions, including potent immunomodulation, antioxidant, anti-inflammation and antitumor activities. To date, more than 200 chemical constituents have been isolated and identified from AR. Among them, isoflavonoids, saponins and polysaccharides are the three main types of beneficial compounds responsible for its pharmacological activities and therapeutic efficacy. After ingestion of AR, the metabolism and biotransformation of the bioactive compounds were extensive in vivo. The isoflavonoids and saponins and their metabolites are the major type of constituents absorbed in plasma. The bioavailability barrier (BB), which is mainly composed of efflux transporters and conjugating enzymes, is expected to have a significant impact on the bioavailability of AR. This review summarizes studies on the phytochemistry, pharmacology and pharmacokinetics on AR. Additionally, the use of AR as a personalized medicine based on the BB is also discussed, which may provide beneficial information to achieve a better and more accurate therapeutic response of AR in clinical practice.

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OralHuangqiFormulae for Stable Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis

Cited by 15 publications

References 15 publications

Effect of Radix Stemonae concentrated decoction on the lung tissue pathology and inflammatory mediators in COPD rats

Effect of Radix Stemonae concentrated decoction on the lung tissue pathology and inflammatory mediators in COPD rats

The Efficacy of Shen Shuaining Capsule on Chronic Kidney Disease: A Systematic Review and Meta‐Analysis

A Systematic Review of Phytochemistry, Pharmacology and Pharmacokinetics on Astragali Radix: Implications for Astragali Radix as a Personalized Medicine

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