The Efficacy of Shen Shuaining Capsule on Chronic Kidney Disease: A Systematic Review and Meta‐Analysis

Abstract

Objective. To evaluate the efficacy of Shen shuaining capsule on treating chronic kidney disease (CKD). Methods. All randomized controlled trials (RCTs) of Shen shuaining capsule in treating CKD were collected from CBM, CNKI, VIP, Wanfang, EMBASE, MEDLINE, PubMed, and Cochrane library clinical controlled trials database. Two reviewers independently performed analysis of the included trials according to the inclusion and exclusion criteria. The risk of bias tool was from the Cochrane Handbook version 5.1.0. The Review Manager 5.2 software was employed for data analysis. Funnel plot and Egger's test were applied to evaluate publication bias. Results. 20 studies including 1606 participants met the inclusion criteria, most of which were of low quality. Meta-analysis indicated that Shen shuaining capsule was effective for CKD in terms of SCR, BUN, Hb, and response rate and with less adverse effects, of which SCR and BUN decreased significantly (MD = −84.72, 95% CI: −107.36, −62.07, P < 0.00001) (MD = −4.30, 95% CI: −5.71, −2.89, P < 0.00001); Hb and response rate increased significantly (MD = 9.94, 95% CI: 9.24, 10.64, P < 0.00001) (OR = 4.25, 95% CI (3.32, 5.42), P < 0.00001). Conclusion. Shen shuaining capsule significantly reduced SCR and BUN, increased HB, and improved total efficiency of the symptoms and signs in patients with CKD. Subgroup analysis found that Shen shuaining capsule group was better than control group. Due to low quality of the methodology of included studies, further high-quality researches were needed to study its efficacy and safety.

CD62P and P10 as predictive markers for assessing the efficacy of hemodialysis in treating end‐stage renal disease

“…End‐stage renal disease (ESRD) is a chronic kidney disease (CKD) manifested as an end stage disease when the irreversibly damaged kidneys disable to maintain the physiological homeostasis of the body, which leads to abnormalities in metabolic waste elimination, disturbances in free water and electrolytes as well as acid‐base imbalance . The clinical manifestations of ESRD are not specific and might include symptoms such as fatigue, anorexia, nausea, edema, soreness in waist, knees, and constipation .…”

Chronic Kidney Disease: Etiology, Pathophysiology, and Management Strategies to Increase Quality of Life

“…As a result, HARC can help prevent the condition from recurring because it has been shown to influence the early stages of stone growth. The mechanism underlying this benefit may be mediated by an antioxidant, nephroprotection, and its influence on urinary stone-forming ingredients and risk factors [53]. Aunaea procumbens efficiently protects rats' kidneys from CCl 4 -induced oxidative damage via the antioxidant and free radical scavenging properties of flavonoids and saponins in the fractions [54].…”

Promoting Plant-Based Therapies for Chronic Kidney Disease

“…These plants and Radix astragali, Salvia miltiorrhiza, Panax notoginseng with Rosewood their extracts are sometimes used alone, but in many countries they are used in polyherbals for the treatment of kidney disease. 36,37 The following section describes these selected plants and their extracts for treating CKD, their mechanisms of action, and their particular beneficial effects for CKD, using pre-clinical and clinical studies. Tables 1 and 2 give a broader list of plants used in pre-clinical and clinical studies for the treatment of CKD.…”