Abstract:Aim: This preliminary study was performed to test the reliability and validity of the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery (MCCB), developed by the National Institute of Mental Health MATRICS initiative, as an assessment tool in a Japanese-language version (MCCB-J).
Methods:The subjects for the present study were 37 patients with schizophrenia. Each subject gave written informed consent to participate in the research. In order to examine… Show more
“…UPSA-B and MCCB. In fact, cognitive function evaluated by the BACS used here has been shown to correlate with performance on the MCCB Japanese version (Kaneda et al, 2013). …”
Section: Discussionmentioning
confidence: 80%
“…Cognitive assessment was conducted by the Japanese version of the Brief Assessment of Cognition in Schizophrenia (BACS) (Kaneda et al, 2013), based on the original version (Keefe et al, 2004). The cognitive domains included in the BACS are verbal memory, working memory, motor speed, verbal fluency, attention, and executive function.…”
Section: Methodsmentioning
confidence: 99%
“…The cognitive domains included in the BACS are verbal memory, working memory, motor speed, verbal fluency, attention, and executive function. The primary measure from each test of the BACS was standardized by creating z-scores whereby the mean score of Japanese healthy controls was set to zero and the standard deviation set to one (Kaneda et al, 2013). A composite score was calculated by averaging all z-scores of the six primary measures.…”
The Specific Levels of Functioning Scale (SLOF) has been reported to provide a measure of social function in patients with schizophrenia. The aim of this multi-center study was to determine convergent validity of the Japanese version of SLOF, and if cognitive insight would be associated with social function. Fifty-eight patients with schizophrenia participated in the study. Social function, neurocognition, and daily activity skills were evaluated by the Social Functioning Scale (SFS), Brief Assessment of Cognition in Schizophrenia (BACS) and UCSD Performance-based Skills Assessment-Brief (UPSA-B), respectively. We also assessed cognitive insight with the Beck Cognitive Insight Scale (BCIS). Significant relationships were noted between scores on the SLOF vs. those of the SFS, BACS, UPSA-B, and BCIS. Specifically, the correlation between performance on the UPSA-B and SLOF scores was significantly more robust compared to the correlation between performance on the UPSA-B and scores on the SFS. Similarly, the correlation between scores on the BACS and SLOF tended to be more robust than that between the BACS and SFS. Importantly, while the correlation between scores on the BCIS and SLOF reached significance, it was not so between scores on the BCIS and SFS. The SLOF Japanese version was found to provide a measure of social consequences in patients with schizophrenia. Importantly, this study is the first to indicate the relationship between cognitive insight and social function evaluated by the SLOF. This finding is consistent with the observation that SLOF scores were considerably associated with performances on objective functional measures.
“…UPSA-B and MCCB. In fact, cognitive function evaluated by the BACS used here has been shown to correlate with performance on the MCCB Japanese version (Kaneda et al, 2013). …”
Section: Discussionmentioning
confidence: 80%
“…Cognitive assessment was conducted by the Japanese version of the Brief Assessment of Cognition in Schizophrenia (BACS) (Kaneda et al, 2013), based on the original version (Keefe et al, 2004). The cognitive domains included in the BACS are verbal memory, working memory, motor speed, verbal fluency, attention, and executive function.…”
Section: Methodsmentioning
confidence: 99%
“…The cognitive domains included in the BACS are verbal memory, working memory, motor speed, verbal fluency, attention, and executive function. The primary measure from each test of the BACS was standardized by creating z-scores whereby the mean score of Japanese healthy controls was set to zero and the standard deviation set to one (Kaneda et al, 2013). A composite score was calculated by averaging all z-scores of the six primary measures.…”
The Specific Levels of Functioning Scale (SLOF) has been reported to provide a measure of social function in patients with schizophrenia. The aim of this multi-center study was to determine convergent validity of the Japanese version of SLOF, and if cognitive insight would be associated with social function. Fifty-eight patients with schizophrenia participated in the study. Social function, neurocognition, and daily activity skills were evaluated by the Social Functioning Scale (SFS), Brief Assessment of Cognition in Schizophrenia (BACS) and UCSD Performance-based Skills Assessment-Brief (UPSA-B), respectively. We also assessed cognitive insight with the Beck Cognitive Insight Scale (BCIS). Significant relationships were noted between scores on the SLOF vs. those of the SFS, BACS, UPSA-B, and BCIS. Specifically, the correlation between performance on the UPSA-B and SLOF scores was significantly more robust compared to the correlation between performance on the UPSA-B and scores on the SFS. Similarly, the correlation between scores on the BACS and SLOF tended to be more robust than that between the BACS and SFS. Importantly, while the correlation between scores on the BCIS and SLOF reached significance, it was not so between scores on the BCIS and SFS. The SLOF Japanese version was found to provide a measure of social consequences in patients with schizophrenia. Importantly, this study is the first to indicate the relationship between cognitive insight and social function evaluated by the SLOF. This finding is consistent with the observation that SLOF scores were considerably associated with performances on objective functional measures.
“…The MCCB has good test-retest reliability, practicability, and tolerability,40 and it is reported that the Japanese version of the MCCB has good psychometric properties and validity 55. It was reported that the Japanese version had high internal consistency (Cronbach coefficient alpha was 0.72) 55. In the present study, data were collected using the Japanese version by clinical psychologists who were well trained for the use of it.…”
Section: Methodsmentioning
confidence: 85%
“…The MCCB composite score gives equal weighting to each of the seven cognitive domains. The MCCB has good test-retest reliability, practicability, and tolerability,40 and it is reported that the Japanese version of the MCCB has good psychometric properties and validity 55. It was reported that the Japanese version had high internal consistency (Cronbach coefficient alpha was 0.72) 55.…”
PurposeThe purpose of the present study was to examine clinical factors related to social function in people with schizophrenia.Patients and methodsThe participants were 55 stabilized outpatients with schizophrenia. Their mean age was 39.36 (SD =10.65) years. Social function was assessed using the Quality of Life Scale (QLS). Cognitive function was evaluated with the Measurement and Treatment Research to Improve Cognition in Schizophrenia Consensus Cognitive Battery (MCCB). Clinical symptoms were assessed using the Positive and Negative Syndrome Scale (PANSS), the Calgary Depression Scale for Schizophrenia, and the Drug-Induced Extrapyramidal Symptoms Scale.ResultsNeither the MCCB cognitive domain score nor composite score was correlated with the QLS scores. However, of the 10 MCCB subtests, the Trail Making Test Part A and the Brief Assessment of Cognition in Schizophrenia-Symbol Coding (BACS-SC) scores were positively correlated with the QLS scores. Among clinical variables, especially the PANSS negative syndrome scale score had a strong negative correlation with the QLS scores. Stepwise regression analyses showed that the PANSS negative syndrome scale score was an independent predictor of the QLS scores, and although the BACS-SC score predicted the QLS common objects and activities subscale score, the association was not so strong compared to the PANSS negative syndrome scale score.ConclusionThese results indicate that speed of processing evaluated by BACS-SC could predict some aspect of social function but negative symptoms have a much stronger impact on global social function in people with schizophrenia.
Aim: MATRICS Consensus Cognitive Battery was developed by the National Institute of Mental Health to establish acceptance criteria for measuring cognitive changes in schizophrenia and can be used to assess cognitive functions in other psychiatric disorders. We used a Japanese version of MATRICS Consensus Cognitive Battery to explore the changes in multiple cognitive functions in patients with mild cognitive impairment and mild Alzheimer's disease. Methods: We administered the Japanese version of MATRICS Consensus Cognitive Battery to 11 patients with mild cognitive impairment (MCI), 11 patients with Alzheimer's disease, and 27 healthy controls. All Japanese versions of MATRICS Consensus Cognitive Battery domain scores were converted to t-scores using sample means and standard deviations and were compared for significant performance differences among healthy control, MCI, and mild Alzheimer's disease groups. Results: Compared with healthy controls, patients with MCI and mild Alzheimer's disease demonstrated the same degree of impairment to processing speed, verbal learning, and visual learning. Reasoning and problem-solving showed significant impairments only in mild Alzheimer's disease. Verbal and visual abilities in working memory showed different performances in the MCI and mild Alzheimer's disease groups, with the Alzheimer's disease group demonstrating significantly more deficits in these domains. No significant difference was found among the groups in attention/vigilance and social cognition. Conclusions: The Japanese version of MATRICS Consensus Cognitive Battery can be used to elucidate the characteristics of cognitive dysfunction of normal aging, MCI, and mild dementia in clinical practice.
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