Comparison of antioxidant activity of hydroethanolic fresh and aged garlic extracts and their effects on cerebral ischemia

The Beneficial Effect of Melatonin in Brain Endothelial Cells against Oxygen-Glucose Deprivation Followed by Reperfusion-Induced Injury

“…In the present study, we induced OGD/R injury, which is known as an appropriate in vitro model of stroke [67, 68], in brain endothelial cells to investigate the effect of ischemia-reperfusion injury. Recent research suggests that antioxidants attenuate oxidative damage induced by ischemia-reperfusion injury by decreasing mechanisms of ROS production [69]. Previous researches have suggested that antioxidants preserve BBB disruption and attenuate ROS generation after cerebral ischemia reperfusion in vivo [70–72] and in vitro [73, 74].…”

Evaluation of the analgesic efficacy of garlic shoots extract in experimental pain models in mice

“…Hence there is a need for new analgesics. Garlic is a global natural herb with medicinal properties 2 like hypoglycemic 3 , memory enhancing 4 , anti-oxidant 5 , antidepressant 6 , anaesthetic 7 , wound healing 8 and antiinflammatory 9 in various animal models. In addition onion extract have been suggested to possess analgesic effects.…”

Allium sativum

“…AGE demonstrated neuroprotective effects in rats with spinal cord injury via its antioxidant activity (Cemil et al 2012 ). Aged garlic extract (AGE) and of 20 % hydroethanolic fresh extracts from garlic clove (GCE) and skin (GSE) protected against cerebral ischaemiainduced injuries in rats (Cervantes et al 2013 ). The results indicated that antioxidants such as SAC present in garlic extracts may regulate ROS concentrations during ischaemia, favour pro-survival pathways and attenuate mitochondrial dysfunction.…”