IgE‐mediated basophil tumour necrosis factor alpha induces matrix metalloproteinase‐9 from monocytes

Falkencrone, Sidsel; Poulsen, Lars K.; Bindslev‐Jensen, Carsten; Woetmann, Anders; Ødum, Niels; Poulsen, Britta C.; Blom, Lars; Jensen, Bettina M.; Gibbs, Bernhard F.; Yasinska, Inna M.; Sumbayev, Vadim V.; Skov, Per Stahl

doi:10.1111/all.12143

Cited by 23 publications

(15 citation statements)

References 29 publications

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“…In contrast to basophils, human mast cells are a factory of a plethora of cytokines such as SCF, TNF‐α, IL‐1β, IL‐3, IL‐5, IL‐6, IL‐9, IL‐10, IL‐11, IL‐13, IL‐16, IL‐22, IL‐25/IL‐17E, GM‐CSF, VEGFs, FGF‐2, NGF, amphiregulin, and TSLP . Mast cells were found to be a cell type producing IL‐17A in patients with inflammatory skin and joint diseases .…”

Section: Mediators Produced By Mast Cells and Basophilsmentioning

confidence: 99%

Human mast cells and basophils—How are they similar how are they different?

Varricchi

Raap

Rivellese

et al. 2018

Immunological Reviews

123

116

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Mast cells and basophils are key contributors to allergies and other inflammatory diseases since they are the most prominent source of histamine as well as numerous additional inflammatory mediators which drive inflammatory responses. However, a closer understanding of their precise roles in allergies and other pathological conditions has been marred by the considerable heterogeneity that these cells display, not only between mast cells and basophils themselves but also across different tissue locations and species. While both cell types share the ability to rapidly degranulate and release histamine following high-affinity IgE receptor cross-linking, they differ markedly in their ability to either react to other stimuli, generate inflammatory eicosanoids or release immunomodulating cytokines and chemokines. Furthermore, these cells display considerable pharmacological heterogeneity which has stifled attempts to develop more effective anti-allergic therapies. Mast cell- and basophil-specific transcriptional profiling, at rest and after activation by innate and adaptive stimuli, may help to unravel the degree to which these cells differ and facilitate a clearer understanding of their biological functions and how these could be targeted by new therapies.

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Section: Mediators Produced By Mast Cells and Basophilsmentioning

confidence: 99%

Human mast cells and basophils—How are they similar how are they different?

Varricchi

Raap

Rivellese

et al. 2018

Immunological Reviews

123

116

View full text Add to dashboard Cite

show abstract

“…There are at least two publications reporting TNF-? production by human basophils (88,102). Numerous attempts to detect this cytokine in supernatants of highly purified human basophils activated by IgE-mediated stimuli have produced negative results.…”

Section: Proinflammatory and Immunoregulatory Mediators/cytokines Relmentioning

confidence: 99%

Is There a Role for Basophils in Cancer?

et al. 2020

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“…Blood basophils constitutively express B cell activating factor BAFF, which is upregulated by TLR2 ligands and fMLP, but not by the TLR4 ligand LPS and not by allergens [100]. Purified basophils secrete TNF-α upon anti-IgE stimulation [101]. …”

Section: Progress In Elucidating the Biological Relevance Of Basophilmentioning

confidence: 99%

News in Cellular Allergology: A Review of the Human Mast Cell and Basophil Granulocyte Literature from January 2013 to May 2015

Hoffmann

2015

Int Arch Allergy Immunol

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Mast cell activation releases the mediators associated with type I allergy. As such, the study of mast cell activation is critical for understanding the allergic reaction, and for developing methods to control it. Importantly, another ligand receptor pair (compound 48/80 and MRGPRX2) that activates mast cells in addition to allergen-IgE-FcεRI has been identified. As mast cells mature in tissue from hematopoietic stem cells, their physiology and pathophysiology is difficult to study. Mast cell lines and mast cells cultured from stem cells are often studied instead of tissue mast cells. There has been some progress in the description of the mechanism of the activation of mast cells, substances limiting mast cell activation and in the catalogue of proteases that mast cells express. Basophil granulocytes express FcεRI, bind IgE and respond to allergen crosslinking in a very similar fashion to mast cells. In the recent literature, basophils were mistakenly described as antigen-presenting cells; this has convincingly been disputed in a number of subsequent publications. Their function in physiology and pathophysiology is not known, but they are frequently used to document allergic sensitisation in the basophil activation test. Significant progress has been made in documenting the relevance of basophil activation as a second-line test in allergy diagnosis. Basophil reactivity and sensitivity may reflect symptom severity and allergen threshold, and are used to document and monitor allergy. The physiology and pathophysiology of allergic effector cells remain an important area of research.

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IgE‐mediated basophil tumour necrosis factor alpha induces matrix metalloproteinase‐9 from monocytes

Cited by 23 publications

References 29 publications

Human mast cells and basophils—How are they similar how are they different?

Human mast cells and basophils—How are they similar how are they different?

Is There a Role for Basophils in Cancer?

News in Cellular Allergology: A Review of the Human Mast Cell and Basophil Granulocyte Literature from January 2013 to May 2015

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