Pure cerebellitis due to scrub typhus: a unique case report

Karanth, Suman S; Gupta, Anurag; Prabhu, Mukhyaprana

doi:10.1177/0049475513480775

Cited by 13 publications

(9 citation statements)

References 6 publications

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“…AC has also been associated with Salmonella typhi, Bordatella pertussis, Borrelia burgdorferi, Mycoplasma, Coxiella burnetii, group A Streptococcus, and Orientia tsutsugamushi. Similar findings have been described in some vaccines [2][3][4][5][6]. It has also been reported to be associated with influenza A and B [7][8][9][10].…”

Section: Introductionsupporting

confidence: 86%

A Rare Cause of Childhood Cerebellitis-Influenza Infection: A Case Report and Systematic Review of Literature

Gökçe

Kurugöl

Aslan

et al. 2017

Case Reports in Pediatrics

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Section: Introductionsupporting

confidence: 86%

A Rare Cause of Childhood Cerebellitis-Influenza Infection: A Case Report and Systematic Review of Literature

Gökçe

Kurugöl

Aslan

et al. 2017

Case Reports in Pediatrics

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“…[13,21] Misra et al, Viswanathan et al, and Karanth et al have reported cerebellar involvement in scrub typhus. [7,22,23] Cerebrovascular accident Chung et al presented a patient with a 2-week history of fever and chills, along with a 1-week history of skin rash. Scrub typhus was diagnosed with indirect immunofluorescence test and a nested PCR.…”

Section: Clinical Featuresmentioning

confidence: 99%

“…A study conducted by Viswanathan et al had showed decreased CSF sugar level in 23% of scrub typhus patients presenting as meningitis. [23] However, CSF sugar can be normal. [22,40,41] Pai et al have demonstrated the presence of rickettsiae in CSF samples from patients with scrub typhus using nested PCR.…”

Section: Investigationsmentioning

confidence: 99%

Neuropsychiatric Manifestations of Scrub Typhus

Mahajan¹,

Mahajan

2017

Journal of Neurosciences in Rural Practice

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Scrub typhus is caused by Orientia tsutsugamushi characterized by focal or disseminated vasculitis and perivasculitis which may involve the lungs, heart, liver, spleen and central nervous system. It was thought to have been eradicated from India. Recently it is being reported from many areas of India. The clinical picture and severity of the symptoms varies widely. The neurological manifestations of scrub typhus are not uncommon but are diverse. Meningoencephalitis is classical manifestation of scrub typhus but cerebellitis, cranial nerve palsies, plexopathy, transverse myelitis, neuroleptic malignant syndrome and Guillan-Barré syndrome are other manifestations reported in literature. The availability of literature on the neurological manifestations of scrub typhus is limited to case reports mainly. This article reviews various neurological manifestations of scrub typhus reported in literature.

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“…The most common neurological presentation in scrub typhus is as meningitis, meningoencephalitis or encephalitis [46] . Others include cerebral venous thrombosis [47] , GuillainBarre Syndrome [48] , transient Parkinsonism and myoclonus [49] , opsoclonus [50] , cerebellitis [51] , transverse myelitis [52] , polyneuropathy [53] , facial palsy [54] , abducens nerve palsy [55] and bilateral optic neuritis [56] . Multi-organ dysfunction is not uncommon in severe scrub typhus infection.…”

Section: Clinical Featuresmentioning

confidence: 99%

Severe scrub typhus infection: Clinical features, diagnostic challenges and management

Peter

Sudarsan

Prakash

et al. 2015

WJCCM

135

121

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Scrub typhus infection is an important cause of acute undifferentiated fever in South East Asia. The clinical picture is characterized by sudden onset fever with chills and non-specific symptoms that include headache, myalgia, sweating and vomiting. The presence of an eschar, in about half the patients with proven scrub typhus infection and usually seen in the axilla, groin or inguinal region, is characteristic of scrub typhus. Common laboratory findings are elevated liver transaminases, thrombocytopenia and leukocytosis. About a third of patients admitted to hospital with scrub typhus infection have evidence of organ dysfunction that may include respiratory failure, circulatory shock, mild renal or hepatic dysfunction, central nervous system involvement or hematological abnormalities. Since the symptoms and signs are non-specific and resemble other tropical infections like malaria, enteric fever, dengue or leptospirosis, appropriate laboratory tests are necessary to confirm diagnosis. Serological assays are the mainstay of diagnosis as they are easy to perform; the reference test is the indirect immunofluorescence assay (IFA) for the detection of IgM antibodies. However in clinical practice, the enzyme-linked immuno-sorbent assay is done due to the ease of performing this test and a good sensitivity and sensitivity when compared with the IFA. Paired samples, obtained at least two weeks apart, demonstrating a ≥ 4 fold rise in titre, is necessary for confirmation of serologic diagnosis. The mainstay of treatment is the tetracycline group of antibiotics or chloramphenicol although macrolides are used alternatively. In mild cases, recovery is complete. In severe cases with multi-organ failure, mortality may be as high as 24%.

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Pure cerebellitis due to scrub typhus: a unique case report

Cited by 13 publications

References 6 publications

A Rare Cause of Childhood Cerebellitis-Influenza Infection: A Case Report and Systematic Review of Literature

A Rare Cause of Childhood Cerebellitis-Influenza Infection: A Case Report and Systematic Review of Literature

Neuropsychiatric Manifestations of Scrub Typhus

Severe scrub typhus infection: Clinical features, diagnostic challenges and management

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