Fc receptor-like 3 (FCRL3) −169 C/T polymorphism and systemic lupus erythematosus: a meta-analysis

Abstract

Our aim was to determine whether the Fc receptor-like 3 (FCRL3) -169 C/T (rs7528684) polymorphism confers susceptibility to systemic lupus erythematosus (SLE). A meta-analysis was conducted on the associations between the FCRL3 -169 C/T polymorphism and the SLE. A total of nine sets of comparisons containing 3,628 patients and 6,490 controls were considered. The meta-analysis showed no association between the SLE and the FCRL3 -169 C allele in all study patients (odds ratio [OR] = 0.999, 95 % confidence interval [CI] = 0.925-1.080, p = 0.986). Stratification by ethnicity indicated no association between the C allele and the SLE in neither Europeans nor Asians (OR = 1.058, 95 % CI = 0.925-1.250, p = 0.414; OR = 0.981, 95 % CI = 0.884-1.088, p = 0.715). Furthermore, analysis using the recessive model, the dominant model, and the homozygote contrast showed the same pattern for the C allele in European and Asian groups, showing no association between the FCRL3 -169 C/T polymorphism and the SLE. Even after excluding studies whose controls were not in Hardy-Weinberg equilibrium, we found that this did not materially affect the meta-analysis results. However, the single Latin American study did show an association between the FCRL3 polymorphism and the SLE under homozygote contrast (OR for CC vs. TT = 2.689, 95 % CI = 1.152-1.277, p = 0.022). This meta-analysis of published studies including 2,544 patients and 3,913 controls demonstrates that the FCRL3 -169 C/T polymorphism does not confer susceptibility to SLE in Europeans or Asians.

Autoantibodies in SLE: Specificities, Isotypes and Receptors

“…The -169C>T SNP in FCRL3 has been associated with SLE in some ethnic groups [238]. This polymorphism alters the NFκB binding site and is associated with FCRL3 mRNA and surface protein expression [239].…”

Investigation of biomarkers in Endometriosis-associated infertility: Systematic Review

“…The FCRL3 gene rs7528684 polymorphism has been investigated in several autoimmune diseases, such as systemic lupus erythematosus (Song et al 2013), multiple sclerosis (Yuan et al 2016, rheumatoid arthritis (Lin et al 2016), among others. A systematic review and meta-analysis was conducted to investigate an association between endometriosis and autoimmune diseases considering that abnormalities in the immune system have been suggested to explain the origin of ectopic endometrial tissues.…”

Human FcR Polymorphism and Disease

“…The −169C > T SNP is not associated with SLE in Chinese (You et al 2008 ), Koreans (Choi et al 2006 ), or Mexican patients with childhood-onset SLE (Ramirez-Bello et al 2013 ), but the association with the presence of autoantibodies in Polish SLE patients suggests a possible role in production of autoantibodies (Piotrowski et al 2013 ). Results of meta-analyses differ on whether the −169C > T is associated with SLE in different ethnicities (Breunis et al 2013 ; Mao et al 2010 ; Song et al 2013 ), and the mechanism(s) through which this variant may contribute to SLE remains unclear.…”