Matrix metalloproteinase-1 gene polymorphisms and periodontitis susceptibility: A meta-analysis based on 11 case-control studies

Hou, Tiezhou; Gao, Ling; Zheng, Jingjing; Liu, Zhongqi; Wu, Cuiyan; Liu, Qing; Wu, Shixun; Guo, Xiong

doi:10.1016/j.gene.2013.02.014

Cited by 8 publications

(6 citation statements)

References 25 publications

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“…Genomic and transcriptomic studies have been focusing on one or a few candidate genes/transcripts . There are also studies where genome‐ or transcriptome‐wide approaches have been conducted, omitting an a priori positive discrimination of certain gene(s) . Regardless of the approach, all studies require the extraction of DNA or RNA from blood, epithelial cells collected from an oral swab, gingival tissue, among other sources.…”

Section: “Omics” Approaches To Periodontitismentioning

confidence: 99%

“…An additional confounder is the low number of evaluated subjects used in contrast to genome‐wide association studies (GWAS) allowing the discrimination of intrapopulation genetic variability. Nevertheless, in large‐scale studies , where these limitations are at least in part overcome, results are not very promising. For instance, in a report by Suzuki et al , five promising genomic markers for periodontitis were detected.…”

Section: “Omics” Approaches To Periodontitismentioning

confidence: 99%

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Uncovering the molecular networks in periodontitis

Trindade

Oppenheim

Helmerhorst

et al. 2014

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Periodontitis is a complex immune-inflammatory disease that results from a preestablished infection in gingiva, mainly due to Gram-negative bacteria that colonize deeper in gingival sulcus and latter periodontal pocket. Host inflammatory and immune responses have both protective and destructive roles. Although cytokines, prostaglandins, and proteases struggle against microbial burden, these molecules promote connective tissue loss and alveolar bone resorption, leading to several histopathological changes, namely destruction of periodontal ligament, deepening of periodontal pocket, and bone loss, which can converge to attain tooth loss. Despite the efforts of genomics, transcriptomics, proteomics/peptidomics, and metabolomics, there is no available biomarker for periodontitis diagnosis, prognosis, and treatment evaluation, which could assist on the established clinical evaluation. Nevertheless, some genes, transcripts, proteins and metabolites have already shown a different expression in healthy subjects and in patients. Though, so far, ‘omics approaches only disclosed the host inflammatory response as a consequence of microbial invasion in periodontitis and the diagnosis in periodontitis still relies on clinical parameters, thus a molecular tool for assessing periodontitis lacks in current dental medicine paradigm. Saliva and gingival crevicular fluid have been attracting researchers due to their diagnostic potential, ease, and noninvasive nature of collection. Each one of these fluids has some advantages and disadvantages that are discussed in this review.

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Section: “Omics” Approaches To Periodontitismentioning

confidence: 99%

Section: “Omics” Approaches To Periodontitismentioning

confidence: 99%

Uncovering the molecular networks in periodontitis

Trindade

Oppenheim

Helmerhorst

et al. 2014

Proteomics Clinical Apps

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show abstract

“…Members of MMP family including MMP-1 have a crucial role in the soft tissue destruction of the periodontium. Meta analyses about the role of MMP-1 polymorphism and increased susceptibility to periodontitis showed inconsistency and highlighted a gap of knowledge in this area [31,32].…”

Section: Discussionmentioning

confidence: 99%

Association of matrix metalloproteinase-1-1607 1G/2G single nucleotide polymorphism genotypes with periodontitis in Iraqi population

et al. 2022

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Objective and background: Periodontitis is an inflammatory disease which is characterized by a progressive loss in the matrix of soft and hard tissue of periodontium particularly the collagen fibers which are cleaved by matrix Metalloproteinase (MMP). Indeed, increased activity of MMP mediates progression of periodontal diseases but population-based genetic variations could determine the susceptibility to the disease. The aim was to investigate association between MMP-1-1607 polymorphism with periodontitis among Iraqi individuals. Subjects and methods: The design of this study was a case-control for Iraqi individuals who were divided into two groups; periodontitis group (cases) and those with healthy periodontium (Control). For each subject, clinical periodontal parameters and demographic characteristics were recorded and venous blood was withdrawn for genetic analysis of MMP-1 by using PCR technique and DNA sequencing. Results: Analysis of MMP-1-1607 genotypes, by Hardy-Weinberg equilibrium, showed significant differences in the total sample. The most predominant MMP-1-1607 genotype among Controls was 1G/2G which was significantly different from periodontitis cohorts. Overall, 13 SNP were detected in periodontitis group versus 17 SNP in Control group. In addition, the periodontitis group showed a significant negative association between the probing pocket depth and MMP-1-1607. Conclusion: Results suggested that polymorphisms in MMP-1-1607 1G/2G may play a protective role and decreasing the susceptibility to periodontitis.

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“…Metalloproteinases show a genetic association with CIPD (Hou et al, 2013). Both proinflammatory cytokines IL-1α and tumor necrosis factor (TNF)-α and the anti-inflammatory cytokines IL-4 and IL-10 demonstrated a correlation with chronic inflammation in patients (Loo et al, 2012).…”

Section: Hla Associations In Cipdmentioning

confidence: 99%