Region-specific role of Rac in nucleus accumbens core and basolateral amygdala in consolidation and reconsolidation of cocaine-associated cue memory in rats

Ding, Zhixia; Wu, Ping; Luo, Yunping; Shi, Haishui; Shen, Haowei; Wang, Shenjun; Lü, Lin

doi:10.1007/s00213-013-3050-8

Cited by 28 publications

(23 citation statements)

References 87 publications

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“…1E), suggesting that actin depolymerization via sys-temic NMIIi may have disrupted the memory's reconsolidation. This is consistent with a demonstrated role for actin polymerization in the reconsolidation of other forms of memory (Mantzur et al 2009;Rehberg et al 2010;Ding et al 2013;Li et al 2015).…”

supporting

confidence: 88%

Memory disrupting effects of nonmuscle myosin II inhibition depend on the class of abused drug and brain region

et al. 2017

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Depolymerizing actin in the amygdala through nonmuscle myosin II inhibition (NMIIi) produces a selective, lasting, and retrieval-independent disruption of the storage of methamphetamine-associated memories. Here we report a similar disruption of memories associated with amphetamine, but not cocaine or morphine, by NMIIi. Reconsolidation appeared to be disrupted with cocaine. Unlike in the amygdala, methamphetamine-associated memory storage was not disrupted by NMIIi in the hippocampus, nucleus accumbens, or orbitofrontal cortex. NMIIi in the hippocampus did appear to disrupt reconsolidation. Identification of the unique mechanisms responsible for NMII-mediated, amygdala-dependent disruption of memory storage associated with the amphetamine class may enable induction of retrieval-independent vulnerability to other pathological memories.

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supporting

confidence: 88%

Memory disrupting effects of nonmuscle myosin II inhibition depend on the class of abused drug and brain region

et al. 2017

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“…Recent research has shown that the motivational and associative components of cocaine-environment associations may be dissociable and are mediated by different brain regions (Theberge et al, 2010; Ding et al, 2013; Wells et al, 2013). NAc pERK may be more involved with the associative component due to the increase after cocaine-context re-exposure regardless of CPP expression.…”

Section: Discussionmentioning

confidence: 99%

Region and context-specific intracellular responses associated with cocaine-induced conditioned place preference expression

et al. 2015

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The development and maintenance of cocaine addiction depend heavily on learned reward-environment associations that can induce drug-seeking behavior and relapse. Understanding the mechanisms underlying these cue-induced conditioned responses is important for relapse prevention. To test whether intracellular responses measured after cocaine conditioned place preference (CPP) expression are context-dependent, we re-exposed cocaine-treated rats (drug-free) to an environment previously paired with cocaine or saline, 24 h after the CPP test. After 8 days of cocaine CPP training with one of two cocaine doses (5 mg/kg or 20 mg/kg, i.p.), CPP was expressed only after conditioning with the higher cocaine dose. In CPP expressing rats, locomotor responses after re-exposure to the cocaine-chamber were greater than in rats re-exposed to the saline-paired chamber. Nucleus Accumbens (NAc) phosphorylated ERK (pERK) levels were increased after re-exposure to the cocaine-paired, but not the saline-paired chamber, regardless of whether or not CPP behavior was expressed. Caudate Putamen (CPu) pERK and FosB protein levels increased after re-exposure to the cocaine chamber only after conditioning with the higher cocaine dose. Conversely, the higher cocaine dose, independent of environment, resulted in increased NAc FosB, ΔFosB and phosphorylated CREB (pCREB) protein levels compared to those conditioned with 5 mg/kg cocaine (non-CPP-expressing). Our results suggest that NAc ERK phosphorylation may be involved with retrieving the contextual information of a cocaine-association, without necessarily motivating the expression of CPP behavior. Additionally, we show distinct patterns of intracellular responses in the NAc and CPu indicating a region-specific role for pERK/pCREB/FosB intracellular signaling in the retrieval of cocaine-context associations.

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“…and saline (1 ml/kg, i.p.) with a 12-hour interval using an adapted protocol based on our previous studies to avoid the ceiling effects of the rewarding effects3839. The injection doses of TFF3 were chosen based on our previous studies.…”

Section: Methodsmentioning

confidence: 99%

mTOR signalling in the nucleus accumbens shell is critical for augmented effect of TFF3 on behavioural response to cocaine

Luo

Han

Shao

et al. 2016

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Neuropeptides play important roles in modulating the rewarding value of abused drugs. Trefoil factor 3 (TFF3) was recently reported to modulate withdrawal syndrome of morphine, but the effects of TFF3 on the cocaine-induced behavioral changes are still elusive. In the present study, cocaine-induced hyperlocomotion and conditioned place preference (CPP) rat paradigms were provided to investigate the role of TFF3 in the reward response to cocaine. High-performance liquid chromatography (HPLC) analysis was used to analyse the dopamine concentration. The results showed that systemic TFF3 administration (0.1 mg/kg i.p.) significantly augmented cocaine- induced hyperlocomotion and CPP formation, without any effects on locomotor activity and aversive or rewarding effects per se. TFF3 significantly augmented the increment of the dopamine concentration in the NAc and the activity of the mTOR signalling pathway induced by acute cocaine exposure (10 mg/kg, i.p.) in the NAc shell, but not the core. The Intra-NAc shell infusion of rapamycin blocked TFF3-induced hyperactivity in cocaine-treatment rats. These findings indicated that TFF3 could potentiate behavioural response to cocaine, which may be associated with regulating dopamine concentration. Furthermore, the findings indicated that mTOR signalling pathway in the NAc shell is important for TFF3-induced enhancement on the cocaine-induced behavioral changes.

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Region-specific role of Rac in nucleus accumbens core and basolateral amygdala in consolidation and reconsolidation of cocaine-associated cue memory in rats

Abstract: Our findings indicate that Rac in the NAc core and BLA are required for the consolidation and reconsolidation of cocaine-associated cue memory, respectively.

Cited by 28 publications

References 87 publications

Memory disrupting effects of nonmuscle myosin II inhibition depend on the class of abused drug and brain region

Memory disrupting effects of nonmuscle myosin II inhibition depend on the class of abused drug and brain region

Region and context-specific intracellular responses associated with cocaine-induced conditioned place preference expression

mTOR signalling in the nucleus accumbens shell is critical for augmented effect of TFF3 on behavioural response to cocaine

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