Infection palustre et état nutritionnel : résultats d’une cohorte d’enfants âgés de 6 à 59 mois au Kivu en République démocratique du Congo

Mitangala, Prudence; D’Alessandro, Umberto; Donnen, Philippe; Hennart, Philippe; Porignon, Denis; Balaluka, Ghislain Bisimwa; Nyarukweba, D. Zozo; Mbiribindi, N. Cobohwa; Wilmet, Marc

doi:10.1016/j.respe.2012.06.404

Cited by 18 publications

(8 citation statements)

References 23 publications

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“…In the same review, it was observed that malaria was a risk factor for malnutrition, which was in line with our study. On the contrary, studies by Ahmed et al[ 23 ] and Mitangala et al[ 24 ] observed a lower risk of malaria parasitemia among children with severe malnutrition. In our study, we used the RDT results and we did not assess the relationship between malnutrition and parasitemia or malaria by severity category.…”

Section: Discussionmentioning

confidence: 89%

“…A case-control study from Ethiopia reported wasting as a contributing risk to malaria [ 21 ]. Some cohort studies showed a lower contributing risk to malaria infection among malnourished children [ 22 – 24 ], although results from other cross-sectional surveys did not report any association between malaria and malnutrition [ 25 , 26 ]. Meanwhile, others observed malaria infection as a risk factor for under-nutrition [ 27 – 29 ].…”

Section: Introductionmentioning

confidence: 99%

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Malaria increased the risk of stunting and wasting among young children in Ethiopia: Results of a cohort study

et al. 2018

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IntroductionGiven the high prevalence of malnutrition in a malaria-endemic setting, improving nutritional status could serve as a tool to prevent malaria. However, the relationship between the two conditions remains unclear. Therefore, this study assessed the association between under-nutrition and malaria among a cohort of children aged 6 to 59 months old.MethodsTwo cohorts of children were followed for 89 weeks in a rural Rift Valley area of Ethiopia. In the first approach (malaria-malnutrition), a cohort of 2,330 non-stunted and 4,204 non-wasted children were included to assess under-nutrition (outcome) based on their previous malaria status (exposure). In the second approach (malnutrition–malaria), a cohort of 4,468 children were followed-up to measure malaria (outcome), taking under-nutrition as an exposure. A weekly home visit was carried out to identify malaria cases. Four anthropometry surveys were conducted, and generalized estimating equation (GEE) method was used to measure the association between undernutrition and malaria.ResultsThe prevalence of stunting was 44.9% in December 2014, 51.5% in August 2015, 50.7% in December 2015 and 48.1% in August 2016. We observed 103 cases with 118 episodes of malaria, 684 new stunting and 239 new wasting cases. The incidence rate per 10,000 weeks of observation was 3.8 for malaria, 50.4 for stunting and 8.2 for wasting. Children with malaria infection, [Adjusted Odds Ratio (AOR) = 1.9; 95% Confidence Interval (CI), 1.2–2.9)] and younger age (AOR = 1.3; 95% CI, 1.1–1.5) were more likely to be stunted. Furthermore, children with malaria infection (AOR = 8.5; 95% CI, 5.0–14.5) and young age group (AOR = 1.6; 95% CI, 1.2–2.1) were more likely to be wasted. However, stunting and wasting were not risk factors of subsequent malaria illness.ConclusionsMalaria infection was a risk factor for stunting and wasting, but stunting or wasting was not associated with subsequent malaria illness. As our study shows that malaria is a risk factor for stunting and wasting, a close follow-up of the nutritional status of such children may be needed.Trial registrationPACT R2014 11000 882128 (8 September 2014).

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Section: Discussionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Malaria increased the risk of stunting and wasting among young children in Ethiopia: Results of a cohort study

et al. 2018

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“…Although the majority of studies showed no association between malnutrition and parasite density 20/25 (80 %); two evaluations showed a risk association: (1) Weight increments on time to peak P. falciparum parasite density in children of undisclosed age and 28 days of follow-up [ 28 ]; (2) Stunting on P. falciparum parasite density above 300/µL in children above 5 years with 25 weeks of follow-up [ 17 ]; while three comparisons showed a protective association: (1) weight increments on time to peak P. falciparum gametocytaemia in children of undisclosed age and 28 days of follow-up [ 28 ]; (2) Stunting on P. falciparum parasite density of above 5000/µL in children above 5 years with undisclosed follow-up time [ 16 ] and (3) Stunting on P. falciparum parasite density of above 5000/µL in children between 0 and 5 years with 1 year of follow-up [ 15 ].…”

Section: Resultsmentioning

confidence: 99%

“…The inability of anthopometry to distinguish the effect of specific nutrient deficiencies that affect growth in children is another limitation of this method [ 62 ]. Only five studies controlled for malaria treatment exposure [ 17 , 22 , 38 , 44 , 47 ] and four controlled for vector control measures [ 15 , 16 , 34 , 47 ]. Prevention of malaria by intermittent preventive treatment was found to improve weight status in children [ 42 , 63 ].…”

Section: Discussionmentioning

confidence: 99%

Association between anthropometry-based nutritional status and malaria: a systematic review of observational studies

FERREIRA

Alexandre

Salinas

et al. 2015

Malar J

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BackgroundMultiple studies in various parts of the world have analysed the association of nutritional status on malaria using anthropometric measures, but results differ due to the heterogeneity of the study population, species of the parasite, and other factors involved in the host and parasite relationship. The aim of this study was to perform a systematic review on the inter-relationship of nutritional status based on anthropometry and malarial infection.MethodsTwo independent reviewers accessed the MEDLINE and LILACS databases using the same search terms related to malaria and anthropometry. Prospective studies associating anthropometry and malaria (incidence or severity) were selected. References from the included studies and reviews were used to increase the review sensitivity. Data were extracted using a standardized form and the quality of the prospective studies was assessed. Selected articles were grouped based on exposures and outcomes.ResultsThe search identified a total of 1688 studies: 1629 from MEDLINE and 59 from LILACS. A total of 23 met the inclusion criteria. Five additional studies were detected by reading the references of the 23 included studies and reviews, totaling 28 studies included. The mean sample size was 662.1 people, ranging from 57 to 5620. The mean follow-up was 365.8 days, ranging from 14 days to 1 year and 9 months, and nine studies did not report the follow-up period. Prospective studies assessing the relationship between malaria and malnutrition were mostly carried out in Africa. Of the 20 studies with malarial outcomes, fifteen had high and five had average quality, with an average score of 80.5 %. Most anthropometric parameters had no association with malaria incidence (47/52; 90.4 %) or parasite density (20/25; 80 %). However, the impact of malnutrition was noted in malaria mortality and severity (7/17; 41.2 %). Regarding the effects of malaria on malnutrition, malaria was associated with very few anthropometric parameters (8/39; 20.6 %).ConclusionsThis systematic review found that most of the evidence associating malaria and malnutrition comes from P. falciparum endemic areas, with a significant heterogeneity in studies’ design. Apparently malnutrition has not a great impact on malaria morbidity, but could have a negative impact on malaria mortality and severity. Most studies show no association between malaria and subsequent malnutrition in P. falciparum areas. In Plasmodium vivax endemic areas, malaria was associated with malnutrition in children. A discussion among experts in the field is needed to standardize future studies to increase external validity and accuracy.

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“…However, results of prospective studies are mixed for the relationship between nutritional status and malaria incidence [ 15 , 17–20 , 25 , 29 , 45 , 46 ]. Stunting, an indicator of chronic malnutrition that may be associated with an underlying impairment of the immune response [ 47 ], has been associated with both decreased [ 23 , 48 ] and increased risks of malaria [ 15 , 41 ]. The source of conflicting results for studies of malnourishment and malaria is unclear.…”

Section: Discussionmentioning

confidence: 99%

Malaria and Nutritional Status Among Children With Severe Acute Malnutrition in Niger: A Prospective Cohort Study

Oldenburg

Guérin

Berthé

et al. 2018

Clinical Infectious Diseases

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Infection palustre et état nutritionnel : résultats d’une cohorte d’enfants âgés de 6 à 59 mois au Kivu en République démocratique du Congo

Cited by 18 publications

References 23 publications

Malaria increased the risk of stunting and wasting among young children in Ethiopia: Results of a cohort study

Malaria increased the risk of stunting and wasting among young children in Ethiopia: Results of a cohort study

Association between anthropometry-based nutritional status and malaria: a systematic review of observational studies

Malaria and Nutritional Status Among Children With Severe Acute Malnutrition in Niger: A Prospective Cohort Study

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