Malaria and Nutritional Status Among Children With Severe Acute Malnutrition in Niger: A Prospective Cohort Study

Oldenburg, Catherine E.; Guérin, Philippe J.; Berthé, Fatou; Grais, Rebecca F.; Isanaka, Sheila

doi:10.1093/cid/ciy207

Cited by 28 publications

(37 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For malaria, especially in community-based studies, the diagnosis is unreliable because fever, one of the main symptoms of malarial disease, is unspecific. It is also not established if a low anthropometric status is a protective or a risk factor for malaria [43, 44].…”

Section: Discussionmentioning

confidence: 99%

Severe acute malnutrition and mortality in children in the community: Comparison of indicators in a multi-country pooled analysis

et al. 2019

View full text Add to dashboard Cite

Objectives This study aims to describe the mortality risk of children in the community who had severe acute malnutrition (SAM) defined by either a mid-upper arm circumference (MUAC) <115mm, a low weight-for-height Z-score (WHZ) <-3 or both criteria. Methods We pooled individual-level data from children aged 6–59 months enrolled in 3 community-based studies in the Democratic Republic of the Congo (DRC), Senegal and Nepal. We estimate the mortality hazard using Cox proportional hazard models in groups defined by either anthropometric indicator. Results In total, we had 49,001 time points provided by 15,060 children available for analysis, summing to a total of 143,512 person-months. We found an increasing death rate with a deteriorating nutritional status for all anthropometrical indicators. Children identified as SAM only by a low MUAC (<115mm) and those identified only by a low WHZ (Z-score <-3) had a similar mortality hazard which was about 4 times higher than those without an anthropometric deficit. Having both a low MUAC and a low WHZ was associated with an 8 times higher hazard of dying compared to children within the normal range. The 2 indicators identified a different set of children; the proportion of children identified by both indicators independently ranged from 7% in the DRC cohort, to 35% and 37% in the Senegal and the Nepal cohort respectively. Conclusion In the light of an increasing popularity of using MUAC as the sole indicator to identify SAM children, we show that children who have a low WHZ, but a MUAC above the cut-off would be omitted from diagnosis and treatment despite having a similar risk of death.

show abstract

Section: Discussionmentioning

confidence: 99%

Severe acute malnutrition and mortality in children in the community: Comparison of indicators in a multi-country pooled analysis

et al. 2019

View full text Add to dashboard Cite

show abstract

“…[16][17][18][19] A recent prospective study found no association between nutritional status and incident malaria, but malaria at baseline was associated with greater weight gain and reduced height gain over time. 20 Here, we examined the association between anthropometry and malaria infection in a population-based sample of children younger than 5 years in a region of Niger where malnutrition and malaria are co-endemic. The study population participated in a cluster-randomized trial for trachoma and all children received mass azithromycin distribution over 3 years.…”

Section: Introductionmentioning

confidence: 99%

Anthropometry and Malaria among Children in Niger: A Cross-Sectional Study

O’Brien

Amza

Kadri

et al. 2018

The American Journal of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

The complex relationship between malnutrition and malaria affects morbidity and mortality in children younger than 5 years, particularly in parts of sub-Saharan Africa where these conditions occur together seasonally. Previous research on this relationship has been inconclusive. Here, we examine the association between anthropometric indicators and malaria infection in a population-based sample of children younger than 5 years in Niger. This cross-sectional study is a secondary analysis of a cluster-randomized trial comparing treatment strategies for trachoma in Niger. We included children aged 6-60 months residing in the 48 communities enrolled in the trial who completed anthropometric and malaria infection assessments at the final study visit. We evaluated the association between anthropometric indicators, including height-for-age -score (HAZ) and weight-for-age-score (WAZ) and indicators of malaria infection, including malaria parasitemia and clinical malaria. In May 2013, we collected data from 1,649 children. Of these, 780 (47.3%) were positive for malaria parasitemia and 401 (24.3%) had clinical malaria. In models of malaria parasitemia, the adjusted odds ratio (aOR) was 1.05 (95% confidence interval [CI]: 1.00-1.10) for HAZ and 1.07 (95% CI: 0.99, 1.15) for WAZ. In models of clinical malaria, the aOR was 1.07 (95% CI: 1.02-1.11) for HAZ and 1.09 (95% CI: 1.01-1.19) for WAZ. Overall, we did not find evidence of an association between most anthropometric indicators and malaria infection. Greater height may be associated with an increased risk of clinical malaria.

show abstract

“…Opinions are mixed on the role of under nutrition in susceptibility to malaria illness and mortality. [12,13] observed a strong seasonal pattern of both malaria incidence and admission to the therapeutic nutritional program,…”

Section: Exposurementioning

confidence: 99%

Malaria and Nutritional Status of Children in Anambra State, Nigeria

Okeke

Ononye

Imakwu

et al. 2020

AJRiZ

View full text Add to dashboard Cite

Malaria is a major cause of morbidity especially in children less than five years of age. This study was conducted to determine the relationship between malaria infection and nutritional status of some purposely selected children aged 0–36 months from hospitals in Anambra State, Nigeria. Data were collected on nutritional status using anthropometric data – age, height, weight and mid-upper arm circumference (MUAC). Malaria infection status was obtained through microscopic examination of thick films blood smears. The prevalence of malnutrition (weight-for-height Z - scores) among malaria uninfected in the community and hospital surveys was 26.7% and 9.2% respectively, while the prevalence among the malaria parasite infected children was 21.4% and 7.4% in the community and hospital respectively. The average number of malnourished children with Z-scores <-2SD were slightly higher than WHO standard. More malaria infected boys had Z-scores <-2SD compared to the WHO standard. Prevalence of malnutrition based on MUAC among malaria parasite infected children was very high (100% and 98.1% in community and hospital, respectively). The average number of stunted (height-for-age Z-score) children in both community and hospital survey was very high compare to WHO standard. It may be concluded that there is a high rate of malnutrition based on MUAC among malaria infected children in Anambra State.

show abstract

Malaria and Nutritional Status Among Children With Severe Acute Malnutrition in Niger: A Prospective Cohort Study

Abstract: We assessed the relationships between nutritional status and malaria infection among children with severe acute malnutrition. Baseline nutritional status was not associated with malaria infection. Malaria infection was associated with increased weight gain and decreased linear growth.

Cited by 28 publications

References 49 publications

Severe acute malnutrition and mortality in children in the community: Comparison of indicators in a multi-country pooled analysis

Severe acute malnutrition and mortality in children in the community: Comparison of indicators in a multi-country pooled analysis

Anthropometry and Malaria among Children in Niger: A Cross-Sectional Study

Malaria and Nutritional Status of Children in Anambra State, Nigeria

Contact Info

Product

Resources

About