SUMMARYAim: Cardiovascular diseases present major cause of morbidity and mortality in the world as well as in Central Serbia. The aim of this study is to analyze the frequency of risk factors and estimate risk for the development of cardiovascular diseases.Methods: The database was collected from health records of the Health Centre in Kragujevac. The following parameters were observed: gender and age, smoking, anthropometrical measurements and Body Mass Index, the value of systolic and diastolic blood pressure, diabetes, levels of cholesterol, and triglycerids in blood serum. The estimation of risk for developing the fatal cardiovascular disease during the period of ten years is determined according to SCORE system model. The statistical package SPSS version 18.0 was used for the statistical analysis.Results: The study sample consisted of 1,053 people, 505 men and 548 women. 68.8% of people were overweight and obese, arterial hypertension was noted in 72.6%, and diabetes type II in 13.3% of people. 67.6% of people had a high level of total cholesterol in blood serum and 39.6% of people had a high level of triglycerids in blood serum. The metabolic syndrome was noted in 44.3%, and 3 or more risk factors for cardiovascular disease were noted in 65% of the population. We determined a significant statistic difference for age, smoking, nutritional status, dyslipidemia, and diabetes.Conclusion: The high incidence of potentially modifiable risk factors for cardiovascular disease gives a possibility to apply prevention measures for promotion and preservation of health.