“…DP has also been noted in a patient with dietary nickel hypersensitivity, in patients with pregnancy pemphigoid, and even in a case of pemphigus. [5][6][7] The pathogenesis of BP involves autoantibodies directed against hemidesmosomal proteins in the basement membrane zone, which in most cases are 180-kDa collagen XVII (BPAG2), a transmembrane protein, and the 230-kDa BP antigen (BPAG1), which is an intracellular protein. 2 The expression of BP antigens is found to be greatest in plantar skin, and this may be the reason for the localization, at least initially, to the soles and palms.…”