Metallothionein 1A polymorphisms may influence urine uric acid and N-acetyl-beta-d-glucosaminidase (NAG) excretion in chronic lead-exposed workers

Yang, Chen-Cheng; Chen, Hsin-I; Chiu, Yu-Wen; Tsai, Chih-Hung; Chuang, Hung‐Yi

doi:10.1016/j.tox.2013.02.007

Cited by 12 publications

(8 citation statements)

References 25 publications

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“…Metallothioneins (MTs) are members of the family of low molecular weight cysteine proteins (molecular weights ranging from 500 to 14,000 daltons) (8) . Metallothionein proteins have the ability to bind to the physiological heavy metals (zinc, cooper, selenium) and non-physiological heavy ions (cadmium, mercury, silver, arsenic), using the thiol group of the cysteine amino acids (Cystine amino acid consist about 30% of the amino acid content of the metallothionein proteins) (9) . They exist in all living organisms and accumulate in the membrane of the golgi apparatus (10) .…”

Section: Introductionmentioning

confidence: 99%

METALLOTHIONEIN-2A (RS1610216&RS28366003) GENE POLYMORPHISMS AND THE RISK OF STOMACH ADENOCARCINOMA

Shokrzadeh

Mohammadpour

Ghassemi-Barghi

et al. 2019

Arq. Gastroenterol.

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BACKGROUND: Gastric cancer is the fourth most common cause of worldwide cancer. Also in contrast to the huge advances in curing, the chance of living is very low even in surgery cases. Having a genetic predisposition plays an important role in cancer development. The association between Metallothionein-2A gene polymorphisms and the risk of adenocarcinoma has been widely studied, yet there is only one study on stomach diseases. OBJECTIVE: In this study, we aimed to investigate the association between 2 (MT-2A) polymorphisms and adenocarcinoma. METHODS: This cross-sectional case control study was performed between Mach 2014 and January 2015 at the Tuba Hospital of Sari, Iran. Peripheral blood samples were collected in EDTA tube. DNA extraction was performed using the spin column procedure. The MT-2A polymorphisms MT-2A (rs1610216), (rs28366003) were determined by polymerase chain reaction-restriction fragment length polymorphism analysis in 95 a topic adenocarcinoma patients and 90 healthy individuals from Iranian population. RESULTS: The MT-2A rs1610216 polymorphism increased the risk of adeno carcinoma in our Iranian population [OR: 3.8533; 95%CI, 1.3155-11.2869; P=0.0139] and rs28366003 [OR: 4.0978; 95%CI, 1.2521-13.4108; P=0.0197]. CONCLUSION: The MT-2A gene polymorphism was associated with the risk of adenocarcinoma in the Iranian population.

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Section: Introductionmentioning

confidence: 99%

METALLOTHIONEIN-2A (RS1610216&RS28366003) GENE POLYMORPHISMS AND THE RISK OF STOMACH ADENOCARCINOMA

Shokrzadeh

Mohammadpour

Ghassemi-Barghi

et al. 2019

Arq. Gastroenterol.

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“…Numerous studies confirm an increase in MT concentration as a response to inflammation [ 30 , 31 , 32 ]. There are numerous reports on the relationship between the polymorphism of genes encoding MT and the concentration of metals in the body [ 29 , 33 , 34 , 35 , 36 ]. To date, the above relationships have not been studied in the group of patients with acute pancreatitis.…”

Section: Discussionmentioning

confidence: 99%

“…The PCR reactions in the MT1A gene (located in exon 2 [ 35 ] in the β-domain coding region of MT molecule), MT1B gene (located in intron 1 [ 5 ] in the β-domain coding region of MT molecule) and MT2A gene (located in 3′UTR [ 49 ]) were performed with 20.0 µL as the final volume of PCR reaction mixture. It consisted of 0.6 μL of primers (working concentration: 10 pmol/μL), 2 µL extracted DNA, 12.8 µL PCR clean water and 4 µL Gold Hot-Start PCR Mix (Cat.…”

Section: Methodsmentioning

confidence: 99%

Importance of Genetic Polymorphisms in MT1 and MT2 Genes in Metals Homeostasis and Their Relationship with the Risk of Acute Pancreatitis Occurrence in Smokers—Preliminary Findings

Ściskalska

Ołdakowska

Milnerowicz

2021

IJMS

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This study was aimed at evaluating the changes in metallothionein (MT) concentration in the blood of patients with acute pancreatitis (AP) and healthy subjects, taking into account the extracellular (plasma) and intracellular (erythrocyte lysate) compartments. The impact of single-nucleotide polymorphisms (SNPs) in the MT1A (rs11640851), MT1B (rs964372) and MT2A (rs10636) genes on MT concentration and their association with the concentration of metals (Cu, Zn, Cd) and ceruloplasmin as Cu-related proteins were analyzed. The concentration of a high-sensitivity C-reactive protein (hs-CRP) and IL-6 as markers of inflammation, and malonyldialdehyde (MDA), superoxide dismutase (SODs) activity and the value of total antioxidant capacity (TAC) as parameters describing the pro/antioxidative balance were also assessed. In the AP patient groups, an increased MT concentration in erythrocyte lysate compared to healthy subjects was shown, especially in individuals with the GG genotype for rs964372 in the MT1B gene. A Zn concentration was especially decreased in the blood of smoking AP patients with the AA genotype for SNP rs11640851 in the MT1A gene and the GC genotype for SNP rs10636 in MT2A, compared to non-smokers with AP, which was accompanied by an increase in the value of the Cu/Zn ratio. The exposure to tobacco smoke xenobiotics increased the risk of AP occurrence in subjects with the CC genotype for SNP rs11640851 in the MT1A gene by more than fourfold. The investigated polymorphisms, rs11640851 in the MT1A gene, rs964372 in the MT1B gene and rs10636 in the MT2A gene, seem to be an important factor in maintaining homeostasis in an organism under oxidative stress conditions.

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“…MT binds to and sequesters Pb. It has been proposed that polymorphisms of MT (MT1 and MT2) may affect binding of Pb to MT and lead to an increased PbB (Chen et al 2010;Fernandes et al 2016;Mitra et al 2017;Yang et al 2013b).…”

Section: Hemochromatosis Gene (Hfementioning

confidence: 99%

Toxicological profile for lead

Abadin

Ashizawa²,

Stevens³

et al. 2020

139

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This toxicological profile is prepared in accordance with guidelines developed by the Agency for Toxic Substances and Disease Registry (ATSDR) and the Environmental Protection Agency (EPA). The original guidelines were published in the Federal Register on April 17, 1987. Each profile will be revised and republished as necessary. The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects information for these toxic substances described therein. Each peer-reviewed profile identifies and reviews the key literature that describes a substance's toxicologic properties. Other pertinent literature is also presented, but is described in less detail than the key studies. The profile is not intended to be an exhaustive document; however, more comprehensive sources of specialty information are referenced. CAS# 7439-92-1

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Metallothionein 1A polymorphisms may influence urine uric acid and N-acetyl-beta-d-glucosaminidase (NAG) excretion in chronic lead-exposed workers

Cited by 12 publications

References 25 publications

METALLOTHIONEIN-2A (RS1610216&RS28366003) GENE POLYMORPHISMS AND THE RISK OF STOMACH ADENOCARCINOMA

METALLOTHIONEIN-2A (RS1610216&RS28366003) GENE POLYMORPHISMS AND THE RISK OF STOMACH ADENOCARCINOMA

Importance of Genetic Polymorphisms in MT1 and MT2 Genes in Metals Homeostasis and Their Relationship with the Risk of Acute Pancreatitis Occurrence in Smokers—Preliminary Findings

Toxicological profile for lead

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