Effect of glucose ingestion in plasma markers of inflammation and oxidative stress: Analysis of 16 plasma markers from oral glucose tolerance test samples of normal and diabetic patients

Choi, Hyo Geun; Jeon, Soon Young; Hong, Won Kyung; Jung, Seung Eun; Kang, Hyun Ju; Kim, Jun Woo; Jeon, Jae‐Pil; Han, Bok Ghee

doi:10.1016/j.diabres.2012.01.005

Cited by 26 publications

(27 citation statements)

References 20 publications

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“…Interestingly, all measured chemokines increased their circulating concentration upon oral glucose stimulation. Our finding is consistent for IL8, but inconsistent for IL6 and MCP1 [34,35], while glucose-stimulated circulating RANTES and fractalkine concentrations have not been reported. It is remarkable that the glucose-stimulated increase in plasma IL6 concentration is within the reported elevation after an acute bout of exercise [36].…”

Section: Discussionsupporting

confidence: 67%

Assessment of the Role of Metabolic Determinants on the Relationship between Insulin Sensitivity and Secretion

et al. 2016

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BackgroundInsulin secretion correlates inversely with insulin sensitivity, which may suggest the existence of a crosstalk between peripheral organs and pancreas. Such interaction might be mediated through glucose oxidation that may drive the release of circulating factors with action on insulin secretion.AimTo evaluate the association between whole-body carbohydrate oxidation and circulating factors with insulin secretion to consecutive oral glucose loading in non-diabetic individuals.MethodsCarbohydrate oxidation was measured after an overnight fast and for 6 hours after two 3-h apart 75-g oral glucose tolerance tests (OGTT) in 53 participants (24/29 males/females; 34±9 y; 27±4 kg/m2). Insulin secretion was estimated by deconvolution of serum C-peptide concentration, β cell function by mathematical modelling and insulin sensitivity from an OGTT. Circulating lactate, free-fatty acids (FFA) and candidate chemokines were assessed before and after OGTT. The effect of recombinant RANTES (regulated on activation, normal T cell expressed and secreted) and IL8 (interleukin 8) on insulin secretion from isolated mice islets was also measured.ResultsCarbohydrate oxidation assessed over the 6-h period did not relate with insulin secretion (r = -0.11; p = 0.45) or β cell function indexes. Circulating lactate and FFA showed no association with 6-h insulin secretion. Circulating chemokines concentration increased upon oral glucose stimulation. Insulin secretion associated with plasma IL6 (r = 0.35; p<0.05), RANTES (r = 0.30; p<0.05) and IL8 (r = 0.41; p<0.05) determined at 60 min OGTT. IL8 was independently associated with in vivo insulin secretion; however, it did not affect in vitro insulin secretion.ConclusionWhole-body carbohydrate oxidation appears to have no influence on insulin secretion or putative circulating mediators. IL8 may be a potential factor influencing insulin secretion.

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Section: Discussionsupporting

confidence: 67%

Assessment of the Role of Metabolic Determinants on the Relationship between Insulin Sensitivity and Secretion

et al. 2016

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“…Fasting glucose(84±1 vs. 87±1mg/dL, P=0.08) and insulin(4[3,9] vs. 3[2,7]uIU/mL, P=0.14) were comparable between both HIV-infected and non-HIV-infected groups. At 120 minutes, glucose levels rose to similar levels within each group(129±8 vs. 114±11 mg/dL, change glucose P≤0.0001 and P=0.04, HIV and non-HIV).…”

Section: Resultsmentioning

confidence: 93%

“…Similar studies investigating inflammation during OGTT in the obese and diabetes populations have generated mixed results, with hyperinsulinemia having decreased, increased or neutral effects on markers of generalized inflammation and immune activation[8, 9]. As some evidence suggests IR is monocyte and macrophage-mediated through inhibition of insulin signaling pathways or impaired GLUT4 translocation[10], we may have anticipated neutral effects of insulin on immune markers during the OGTT if this were an exclusive and unidirectional relationship.…”

Section: Discussionmentioning

confidence: 94%

Acute hyperinsulinemia effects on systemic markers of immune activation in HIV

O’Malley

Burdo²,

Robinson³

et al. 2017

Aids

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Summary The well-treated HIV population remains at risk for insulin resistance and chronic immune activation. We tested the effects of acute hyperinsulinemia on inflammation in HIV. Twenty HIV-infected and 10 non-HIV-infected individuals well-matched for BMI underwent oral glucose tolerance testing to stimulate insulin secretion and assess for changes in circulating sCD163, sCD14, and MCP-1. sCD14 decreased significantly after stimulation of hyperinsulinemia and no significant changes in sCD163 or MCP-1 were demonstrated in HIV-infected and non-HIV-infected groups.

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“…Należy ono do białek ostrej fazy i jest syntetyzowane głównie w wątrobie. Aczkolwiek w ostatnich latach wykazano, że źródłem CRP jest nie tylko wą-troba, ale również makrofagi [23][24]. Białko CRP jest produkowane w odpowiedzi na działanie interleukiny-6 (IL-6).…”

Section: Correlation Of Serum Concentrations Of Cxcl8/il8 Clinical Anunclassified

“…Białko CRP jest produkowane w odpowiedzi na działanie interleukiny-6 (IL-6). Na powierzchni śródbłonka nasila ekspresję cząstek adhezyjnych oraz syntezę białka CXCL8/IL8, zmniejsza biodostępność tlenku azotu i bierze udział w aktywacji składowych dopełniacza [24]. Z drugiej strony CXCL8/IL8 indukuje aktywacje i migrację monocytów/makrofagów, granulocytów zasadochłonnych, limfocytów CD4 oraz komórek NK.…”

Section: Correlation Of Serum Concentrations Of Cxcl8/il8 Clinical Anunclassified

Serum concentrations of selected chemokines (CXCL1/GROα and CXCL8/IL8) in patients with type 1 diabetes

Zorena¹,

Jachimowicz-Duda²,

Raczyńska³

2014

Pediatr. Endocrinol.

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Zorena K. i inni: Ocena stężenia wybranych chemokin (CXCL1/GROα oraz CXCL8/IL8) w surowicy pacjentów z cukrzycą typu 1Vol. 13/2014 Nr 1(46) Endokrynologia Pediatryczna Pediatric Endocrinology 9Celem pracy była ocena stężeń wybranych chemokin (CXCL1/GROα) oraz interleukiny 8 (CXCL8/IL8) w surowicy pacjentów z cukrzycą typu 1 (T1DM). Pacjenci i metody. Badania przeprowadzono w grupie 59 pacjentów z T1DM, których podzielono na trzy grupy. W pierwszej grupie było 23 pacjentów z proliferacyjną retinopatią cukrzycową (PDR), w drugiej grupie -15 młodocianych pacjentów z T1DM oraz nieproliferacyjną retinopatią cukrzycową (NPDR), w trzeciej grupie -21 pacjentów z T1DM, lecz bez objawów retinopatii cukrzycowej. U wszystkich pacjentów z T1DM wykonano badania biochemiczne, całodobowy pomiar ciśnienia tętniczego, badania okulistyczne oraz oznaczono stężenia chemokin CXCL1/GROα oraz CXCL8/IL8 w surowicy krwi metodą immunoenzymatyczną (ELISA). Wyniki. U pacjentów z T1DM oraz PDR wykryto znamiennie wyższe stężenie CXCL8/IL8 w surowicy w porównaniu z grupą pacjentów z T1DM oraz NPDR jak też w porównaniu z grupą pacjentów z T1DM, ale bez objawów retinopatii cukrzycowej (226,9±58,3 vs 142,6±32,2pg/ml vs 89,3±15,9). Natomiast nie wykryto różnic znamiennie statystycznych porównując stężenia CXCL-1/Gro-α w surowicy w grupie pacjentów z T1DM i PDR z grupą pacjentów z T1DM oraz NPDR, a także w porównaniu z grupą pacjentów z T1DM bez retinopatii cukrzycowej (69±17 vs 53±12pg/ml vs 47±13). Analiza modelu wielokrotnej regresji krokowej wykazała, że czas trwania cukrzycy, HbA1c oraz białko CRP są niezależnymi czynnikami wpływającymi na poziom CXCL8/IL8 u pacjentów z retinopatią cukrzycową. Współczynnik determinacji dla tego modelu określono na poziomie R 2 =26%. Ponadto na podstawie analizy krzywych Receiver Operating Characteristic (ROC) dla surowiczego stężenia CXCL8/IL8 określono próg referencyjny AUC ROC na poziomie 218 pg/ml. Wnioski. Nasze wyniki badań wskazują na udział w reakcji zapalnej chemokiny CXCL8/IL8, lecz nie CXCL1/GRO-α u pacjentów z T1DM. Sugerujemy, ze oprócz badania STRESZCZENIE/ABSTRACTOcena stężenia wybranych chemokin (CXCL1/GROα oraz CXCL8/IL8) w surowicy pacjentów z cukrzycą typu 1

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Effect of glucose ingestion in plasma markers of inflammation and oxidative stress: Analysis of 16 plasma markers from oral glucose tolerance test samples of normal and diabetic patients

Cited by 26 publications

References 20 publications

Assessment of the Role of Metabolic Determinants on the Relationship between Insulin Sensitivity and Secretion

Assessment of the Role of Metabolic Determinants on the Relationship between Insulin Sensitivity and Secretion

Acute hyperinsulinemia effects on systemic markers of immune activation in HIV

Serum concentrations of selected chemokines (CXCL1/GROα and CXCL8/IL8) in patients with type 1 diabetes

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