Salzmann's nodular degeneration is a slowly progressive, degenerative condition of the cornea that is rare, noninflammatory, and characterized by bluish-white nodules on the corneal surface.
EtiologyThe disease can be idiopathic, but often times, it is from chronic ocular surface irritation and associated with preexisting corneal diseases. It often presents in patients with a history of keratitis, most commonly trachomatous or phlyctenular, but also in vernal or other forms of keratitis caused by scarlet fever, measles, and uveitis (Das et al. 2005). Other associations include epithelial basement membrane dystrophy, Thygeson's punctate keratitis, postcorneal surgery, keratoconus, contact lens, and ocular trauma.