Transcription profiling of immune genes during parasite infection in susceptible and resistant strains of the flour beetles (Tribolium castaneum)

Zhong, Daibin; Wang, Mei-Hui; Pai, Aditi; Yan, Guiyun

doi:10.1016/j.exppara.2013.01.014

Cited by 11 publications

(9 citation statements)

References 37 publications

(41 reference statements)

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“…table 1B), they seem to contradict the concept that the imd pathway is not required during the anti-EPN response. However, they are consistent with the possible attacin function implicated from its differential induction in a different worm infection model involving a tapeworm and the flour beetle as a host [44]. Possible explanations for this discrepancy may be a JNK-dependent induction and/or a developmentally regulated constitutive expression of this gene.…”

Section: Discussionsupporting

confidence: 62%

Genome-Wide Transcriptional Analysis of Drosophila Larvae Infected by Entomopathogenic Nematodes Shows Involvement of Complement, Recognition and Extracellular Matrix Proteins

et al. 2013

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Heterorhabditis bacteriophora is an entomopathogenic nematode (EPN) which infects its host by accessing the hemolymph where it releases endosymbiotic bacteria of the species Photorhabdus luminescens. We performed a genome-wide transcriptional analysis of the Drosophila response to EPN infection at the time point at which the nematodes reached the hemolymph either via the cuticle or the gut and the bacteria had started to multiply. Many of the most strongly induced genes have been implicated in immune responses in other infection models. Mapping of the complete set of differentially regulated genes showed the hallmarks of a wound response, but also identified a large fraction of EPN-specific transcripts. Several genes identified by transcriptome profiling or their homologues play protective roles during nematode infections. Genes that positively contribute to controlling nematobacterial infections encode: a homolog of thioester-containing complement protein 3, a basement membrane component (glutactin), a recognition protein (GNBP-like 3) and possibly several small peptides. Of note is that several of these genes have not previously been implicated in immune responses.

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Section: Discussionsupporting

confidence: 62%

Genome-Wide Transcriptional Analysis of Drosophila Larvae Infected by Entomopathogenic Nematodes Shows Involvement of Complement, Recognition and Extracellular Matrix Proteins

et al. 2013

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“…The red flour beetle (Tribolium castaneum) has received much attention and its immune response shares many similarities with Drosophila (Altincicek et al, 2008(Altincicek et al, , 2013Yokoi et al, 2012a,b;Zhong et al, 2013;Zou et al, 2007). Comparative genome analysis shows 1:1 orthology of intracellular immune signaling pathways (Toll, IMD and JAK/STAT) with Drosophila.…”

Section: Introductionmentioning

confidence: 97%

Immune competence in insect eggs depends on the extraembryonic serosa

Jacobs

Zee

2013

Developmental & Comparative Immunology

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“…It is unknown whether similar mechanisms are also present in those cestode species that have invertebrates in their life-cycle. Hymenolepis diminuta seems to be a perfect model to explore whether a tapeworm needs to cope with an invertebrate intermediate and the mammalian definitive hosts in different ways [ 6 , 24 , 25 ]. This will help in understanding how H .…”

Section: Introductionmentioning

confidence: 99%

Identification of immunogenic proteins of the cysticercoid of Hymenolepis diminuta

et al. 2017

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BackgroundA wide range of molecules are used by tapeworm metacestodes to establish successful infection in the hostile environment of the host. Reports indicating the proteins in the cestode-host interactions are limited predominantly to taeniids, with no previous data available for non-taeniid species. A non-taeniid, Hymenolepis diminuta, represents one of the most important model species in cestode biology and exhibits an exceptional developmental plasticity in its life-cycle, which involves two phylogenetically distant hosts, arthropod and vertebrate.ResultsWe identified H. diminuta cysticercoid proteins that were recognized by sera of H. diminuta-infected rats using two-dimensional gel electrophoresis (2DE), 2D-immunoblotting, and LC-MS/MS mass spectrometry. Proteomic analysis of 42 antigenic spots revealed 70 proteins. The largest number belonged to structural proteins and to the heat-shock protein (HSP) family. These results show a number of the antigenic proteins of the cysticercoid stage, which were present already in the insect host prior to contact with the mammal host. These are the first parasite antigens that the mammal host encounters after the infection, therefore they may represent some of the molecules important in host-parasite interactions at the early stage of infection.ConclusionsThese results could help in understanding how H. diminuta and other cestodes adapt to their diverse and complex parasitic life-cycles and show universal molecules used among diverse groups of cestodes to escape the host response to infection.Electronic supplementary materialThe online version of this article (10.1186/s13071-017-2519-4) contains supplementary material, which is available to authorized users.

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Transcription profiling of immune genes during parasite infection in susceptible and resistant strains of the flour beetles (Tribolium castaneum)

Cited by 11 publications

References 37 publications

Genome-Wide Transcriptional Analysis of <b><i>Drosophila</i></b> Larvae Infected by Entomopathogenic Nematodes Shows Involvement of Complement, Recognition and Extracellular Matrix Proteins

Genome-Wide Transcriptional Analysis of <b><i>Drosophila</i></b> Larvae Infected by Entomopathogenic Nematodes Shows Involvement of Complement, Recognition and Extracellular Matrix Proteins

Immune competence in insect eggs depends on the extraembryonic serosa

Identification of immunogenic proteins of the cysticercoid of Hymenolepis diminuta

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