The Prevalence of Human Papillomavirus in Ovarian Cancer: A Systematic Review

Rosa, Maria Inês da; Silva, Geraldo Doneda; Simões, Priscyla Waleska; Souza, Meriene Viquetti de; Panatto, Ana Paula Ronzani; Simon, Carla Sasso; Madeira, Kristian; Medeiros, Lídia Rossi

doi:10.1097/igc.0b013e318280f3e0

Cited by 32 publications

(39 citation statements)

References 25 publications

(24 reference statements)

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“…The etiology of OCa is multifactorial; the main causes are genetic, environmental, and sexual behavior and HPV which is the main pathogen that leads to OCa (21). Previous studies report different ranges of HPV prevalence in OCa, even some studies were unable to detect HPV in OCa (21)(22)(23)(24). A wide range of study results do not demonstrate the exact prevalence of HPV and this could be because of different study conditions like the type of histopathology sampling, sample transferring and storage condition, the type of method that is used for HPV detection, molecular technique conditions, the time of the study, OCa stage, and patient conditions like age, race and ethnicity, sexual behavior, and the genetics.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, they showed that the prevalence of HPV-16 increased during 2000 to 2005 and started to decrease after 2006 in OCa patients (24). The highest prevalence of HPV in OCa patients was 26.9% -35.9%, all of whom were from China (24,29,30). Our results, in comparison with previous studies, showed that the prevalence of HPV-16 in OCa patients has increased in our country; it, of course, could be predicted as the highest prevalence of HPV is in Asia among the continents.…”

Section: Discussionmentioning

confidence: 99%

“…Atalay (2007) in Turkey reported 8.5 % HPV in OCa patients (21). Rosa et al (2013) in a meta-analysis study showed a range of 0% to 66.7% HPV prevalence with a mean of 17.5% in OCa patients and, more, reported the highest HPV prevalence in Asia at 31.4%. In addition, they showed that the prevalence of HPV-16 increased during 2000 to 2005 and started to decrease after 2006 in OCa patients (24).…”

Section: Discussionmentioning

confidence: 99%

“…Rosa et al (2013) in a meta-analysis study showed a range of 0% to 66.7% HPV prevalence with a mean of 17.5% in OCa patients and, more, reported the highest HPV prevalence in Asia at 31.4%. In addition, they showed that the prevalence of HPV-16 increased during 2000 to 2005 and started to decrease after 2006 in OCa patients (24). The highest prevalence of HPV in OCa patients was 26.9% -35.9%, all of whom were from China (24,29,30).…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, the role of HPV in OCa tumor genesis is less clear due to the mentioned reasons. Most European studies have reported negative HPV detection results in OCa patients with a prevalence rang of 0% to 8 % HPV positive (22)(23)(24)(25)(26). In this study we detected 36 % HPV-16 in the patients with OCa.…”

Section: Discussionmentioning

confidence: 99%

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Detection of Human Papilloma Virus Type 16 in Epithelial Ovarian Tumors Samples

Dadashi

Eslami

Faghihloo

et al. 2016

Arch Clin Infect Dis

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Background: Ovarian carcinoma is the most common malignancy in women and is a cancer with a 15% -50% prevalence in the world. Human papilloma virus (HPV) is considered a factor in cervical and ovarian cancer (OCa) and is related to squamous cell carcinoma in the cervical region. The effect of fixed infection may cause chronic inflammation, in the cancer of ovaries it has received very rare attention, although a background of pelvic inflammatory disease (PID) in a case-control study is associated with a higher risk for ovarian carcinoma. HPV-16 is one type of HPV and the most common and important cause of cervical carcinoma in the developed world. Objectives: The aim of this investigation was to evaluate the incidence of HPV-16 in patients with OCa who referred to Imam Hossein hospital of Shahid Beheshti University of Medical Sciences, Tehran, Iran. Methods: In this case-control study that was conducted since May 2015 to October 2015 in Tehran, 140 samples were studied which were obtained from patients with OCa. After obtaining the samples from OCa tissue by a pathologist, for DNA extraction, samples were transferred to the laboratory of the university. DNA was extracted with Kit (intron biotechnology Co. Korea) according to the manufacturer's instructions. To confirm the presence of HPV-16 in the samples of OCa, specific primers for the L1 gene of HPV were designed and standard PCR method was used for the detection of HPV. PCR product was sequenced to confirm the presence of HPV-16. Results: Out of 140 samples of OCa, 70 (50%) samples were malignant cancer and 70 (50%) were benign cancer as the control group. Out of 70 malignant samples 25 (36.0%) were HPV-16 positive. 2.8% of the tissue samples of the control group were positive for HPV-16. Conclusions: These results show a feasible role of HPV-16 in the carcinogenesis of OCa. According to these results, infection with HPV may play a relative role in the spread of OCa or it could comfort its development.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Detection of Human Papilloma Virus Type 16 in Epithelial Ovarian Tumors Samples

Dadashi

Eslami

Faghihloo

et al. 2016

Arch Clin Infect Dis

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Squamous Cell Carcinoma of the Ovary

Spencer

Rice

2014

Uncommon Gynecologic Cancers

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Prevalence of human papillomavirus detection in ovarian cancer: a meta-analysis

Cherif

Thies

Taube

et al. 2021

Eur J Clin Microbiol Infect Dis

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We conducted a meta-analysis of published data to update and estimate the prevalence of HPV in ovarian cancer. A comprehensive literature search was performed according to the PRISMA guidelines. Eligible articles published from 1989 until 2020 by searching Web of Sciences, Pubmed, Embase, and the Cochrane Library Central databases were gathered. A pooled estimation of HPV prevalence with a 95% confidence interval (CI) was calculated based on a random effect model. Quantitative assessment of heterogeneity was explored using Cochrane test and I2. Additionally, publication bias, sensitivity, meta-regression, and subgroup analyses were also performed. Twenty-nine studies involving 2280 patients with ovarian cancer were included. The statistical heterogeneity was high (I2 = 88%, P<0.0001). The pooled prevalence of HPV in ovarian cancer cases was 15.9% (95% CI, 11–22). In subgroup analyses, the highest prevalence of HPV was reported by studies from Asia (30.9%; 95% CI, 20–44) and Eastern Europe (29.3%; 95% CI, 4.4–78). Furthermore, the most frequently detected HPV genotype was HPV16 (54%; 95% CI, 27.9–55), followed by HPV18 (23.2%; 95% CI, 18.8–28.2). Our meta-analysis suggests a great difference in the prevalence of HPV detected in ovarian cancer by different studies, which is not seen in strongly HPV-associated cancers such as cervical cancer. However, the prevalence varied markedly by geographic region. Considering the substantial heterogeneity found, more studies with control groups and precise assays measuring HPV mRNA expression are needed to further evaluate the link and causative aetiology between HPV and ovarian cancer.

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The Prevalence of Human Papillomavirus in Ovarian Cancer: A Systematic Review

Abstract: We found a high prevalence of HPV-positive DNA in ovarian cancer cases, but the role of HPV in ovarian cancer remains inconclusive. Further studies are needed to control case to answer this question.

Cited by 32 publications

References 25 publications

Detection of Human Papilloma Virus Type 16 in Epithelial Ovarian Tumors Samples

Detection of Human Papilloma Virus Type 16 in Epithelial Ovarian Tumors Samples

Squamous Cell Carcinoma of the Ovary

Prevalence of human papillomavirus detection in ovarian cancer: a meta-analysis

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