Salt and Pepper Distribution of Cell Types in the Collecting Duct

Sampogna, Rosemary V.; Al‐Awqati, Qais

doi:10.1681/asn.2012121183

Cited by 7 publications

(10 citation statements)

References 12 publications

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“…This more primitive appearance of the collecting duct is similar to that of frog skin, reptilian bladder, and fish gills (20)(21)(22). In the kidney, the transition from the early part of the distal convoluted tubule to an epithelium containing both principal and intercalated cells coincides with the transition to segments that are derived from the ureteric bud outpouching of the Wolffian duct (2).…”

Section: Intercalated Cell Distribution Nomenclature Morphology Anmentioning

confidence: 52%

“…In the collecting duct, principal and intercalated cells form a "salt and pepper" epithelium ( Figures 1 and 2) (20). This more primitive appearance of the collecting duct is similar to that of frog skin, reptilian bladder, and fish gills (20)(21)(22).…”

Section: Intercalated Cell Distribution Nomenclature Morphology Anmentioning

confidence: 82%

“…The question remains of how these two disparate cell types coordinate their function in these epithelia (20,34). The plasma membrane of each epithelial cell organizes into apical and basolateral domains that develop distinct membrane lipid and transport protein compositions.…”

Section: Intercalated Cell Distribution Nomenclature Morphology Anmentioning

confidence: 99%

“…In addition to the above factors, the Notch signaling pathway also controls the development of primitive epithelia, such as the ones in the connecting segment and the collecting duct (20,48). The Notch signaling cascade is essential for a developmental process called lateral inhibition, where neighboring cells undergo one final step that gives them very different phenotypes.…”

Section: Intercalated Cell Distribution Nomenclature Morphology Anmentioning

confidence: 99%

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Collecting Duct Intercalated Cell Function and Regulation

Roy¹,

Al‐bataineh²,

Pastor-Soler

2015

Clinical Journal of the American Society of Nephrology

202

213

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Intercalated cells are kidney tubule epithelial cells with important roles in the regulation of acid-base homeostasis. However, in recent years the understanding of the function of the intercalated cell has become greatly enhanced and has shaped a new model for how the distal segments of the kidney tubule integrate salt and water reabsorption, potassium homeostasis, and acid-base status. These cells appear in the late distal convoluted tubule or in the connecting segment, depending on the species. They are most abundant in the collecting duct, where they can be detected all the way from the cortex to the initial part of the inner medulla. Intercalated cells are interspersed among the more numerous segment-specific principal cells. There are three types of intercalated cells, each having distinct structures and expressing different ensembles of transport proteins that translate into very different functions in the processing of the urine. This review includes recent findings on how intercalated cells regulate their intracellular milieu and contribute to acid-base regulation and sodium, chloride, and potassium homeostasis, thus highlighting their potential role as targets for the treatment of hypertension. Their novel regulation by paracrine signals in the collecting duct is also discussed. Finally, this article addresses their role as part of the innate immune system of the kidney tubule.

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Section: Intercalated Cell Distribution Nomenclature Morphology Anmentioning

confidence: 52%

Section: Intercalated Cell Distribution Nomenclature Morphology Anmentioning

confidence: 82%

Section: Intercalated Cell Distribution Nomenclature Morphology Anmentioning

confidence: 99%

Section: Intercalated Cell Distribution Nomenclature Morphology Anmentioning

confidence: 99%

See 2 more Smart Citations

Collecting Duct Intercalated Cell Function and Regulation

Roy¹,

Al‐bataineh²,

Pastor-Soler

2015

Clinical Journal of the American Society of Nephrology

202

213

View full text Add to dashboard Cite

show abstract

“…There is limited knowledge of the UBTC transcriptome at the earliest stages of mouse and rat kidney development (7). Current models posit that UBTC give rise to bipotent UB precursors capable of differentiating to PC or IC and that Notch and Foxi1 signaling dictate the decisions for fate commitment and/or are required for fate maintenance (2,8,9). However, a number of fundamental questions remain unanswered.…”

Section: Introductionmentioning

confidence: 99%