p63+ ureteric bud tip cells are progenitors of intercalated cells

El‐Dahr, Samir S.; Li, Yuwen; Liu, Jiao; Gutierrez, Elleny; Hering-Smith, Kathleen S.; Signoretti, Sabina; Pignon, Jean‐Christophe; Sinha, Satrajit; Saifudeen, Zubaida

doi:10.1172/jci.insight.89996

Cited by 15 publications

(12 citation statements)

References 38 publications

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“…1 Moreover, p63 was identified to specifically define a subpopulation of UB tip cells, responsible for the formation of intercalated cells. 24 The genetic determinants of UB branching have been studied extensively, 25 while epigenetic regulations in this process are relatively less studied.…”

Section: Epigenetic Regulation Of Ubmentioning

confidence: 99%

Epigenetic regulation of kidney progenitor cells

Huang

Liu

Vonk

et al. 2020

Stem Cells Translational Medicine

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The reciprocal interactions among the different embryonic kidney progenitor populations lay the basis for proper kidney organogenesis. During kidney development, three types of progenitor cells, including nephron progenitor cells, ureteric bud progenitor cells, and interstitial progenitor cells, generate the three major kidney structures-the nephrons, the collecting duct network, and the stroma, respectively. Epigenetic mechanisms are well recognized for playing important roles in organism development, in fine-tuned control of physiological activities, and in responses to environment stimuli. Recently, evidence supporting the importance of epigenetic mechanisms underlying kidney organogenesis has emerged. In this perspective, we summarize the research progress and discuss the potential contribution of novel stem cell, organoid, and next-generation sequencing tools in advancing this field in the future.

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Section: Epigenetic Regulation Of Ubmentioning

confidence: 99%

Epigenetic regulation of kidney progenitor cells

Huang

Liu

Vonk

et al. 2020

Stem Cells Translational Medicine

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show abstract

“…The elaborated analysis of the imaging studies then confirmed that UB tips are the sites where the progenitor population for collecting ducts and ureter reside. Further genetic studies have revealed that Notch signaling is required for patterning the distribution of FOXI1+ principal and AQP2+ intercalated cells within the mature collecting duct while several additional genes including at least methyltransferase Dot1l, and transcription factors p63 and Tfcp2L1 contribute to the balanced differentiation of each cell type [ 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 ] (for a more detailed overview, see, e.g., [ 101 , 102 ]). It remains to be studied whether collecting duct progenitor maintenance and loss before birth has any link to the previously reported bi-phasic and time-dependent UB branching topology [ 64 ].…”

Section: Collecting Duct Progenitorsmentioning

confidence: 99%

Embryonic Kidney Development, Stem Cells and the Origin of Wilms Tumor

Hohenstein

Kuure

2021

Genes

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The adult mammalian kidney is a poorly regenerating organ that lacks the stem cells that could replenish functional homeostasis similarly to, e.g., skin or the hematopoietic system. Unlike a mature kidney, the embryonic kidney hosts at least three types of lineage-specific stem cells that give rise to (a) a ureter and collecting duct system, (b) nephrons, and (c) mesangial cells together with connective tissue of the stroma. Extensive interest has been raised towards these embryonic progenitor cells, which are normally lost before birth in humans but remain part of the undifferentiated nephrogenic rests in the pediatric renal cancer Wilms tumor. Here, we discuss the current understanding of kidney-specific embryonic progenitor regulation in the innate environment of the developing kidney and the types of disruptions in their balanced regulation that lead to the formation of Wilms tumor.

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“…vHNF1 (Garcia-Villalba et al, 2009), EMX2 (Empty spiracles homolog 2) (Miyamoto et al, 1997), PAX2 (Dressler et al, 1990), LHX1 (Karavanov et al, 1998), GATA3 (Grote, 2005;Grote et al, 2008), RET (Pachnis et al, 1993), WNT11 (Majumdar, 2003), and Vsnl1 (Bridgewater et al, 2011) are expressed in the UB tips and they specify its cell fate. Results from studies indicate that a sub-population of UBPCs, which express the Np63 isoform (N-terminus truncated p63) is dedicated to generating cortical intercalated cells (El-dahr et al, 2017). FOXi1 and a disintegrin and metalloproteinase domain 10 (Adam10)/Notch signaling pathway play critical roles in intercalated and principal cell fate decision in the collecting duct, respectively (Al- Awqati and Schwartz, 2004;Jeong et al, 2009;Vidarsson et al, 2009;Guo et al, 2015).…”

Section: Ureteric Bud Progenitor Cells (Ubpcs)mentioning

confidence: 99%

Cellular and Molecular Mechanisms of Kidney Development: From the Embryo to the Kidney Organoid

Rad

Aghdami

Moghadasali

2020

Front. Cell Dev. Biol.

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Development of the metanephric kidney is strongly dependent on complex signaling pathways and cell-cell communication between at least four major progenitor cell populations (ureteric bud, nephron, stromal, and endothelial progenitors) in the nephrogenic zone. In recent years, the improvement of human-PSC-derived kidney organoids has opened new avenues of research on kidney development, physiology, and diseases. Moreover, the kidney organoids provide a three-dimensional (3D) in vitro model for the study of cell-cell and cell-matrix interactions in the developing kidney. In vitro recreation of a higher-order and vascularized kidney with all of its complexity is a challenging issue; however, some progress has been made in the past decade. This review focuses on major signaling pathways and transcription factors that have been identified which coordinate cell fate determination required for kidney development. We discuss how an extensive knowledge of these complex biological mechanisms translated into the dish, thus allowed the establishment of 3D human-PSC-derived kidney organoids.

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p63+ ureteric bud tip cells are progenitors of intercalated cells

Cited by 15 publications

References 38 publications

Epigenetic regulation of kidney progenitor cells

Epigenetic regulation of kidney progenitor cells

Embryonic Kidney Development, Stem Cells and the Origin of Wilms Tumor

Cellular and Molecular Mechanisms of Kidney Development: From the Embryo to the Kidney Organoid

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