Association between the ghrelin Leu72Met polymorphism and type 2 diabetes risk: A meta-analysis

Liao, Ning; Xie, Z.; Huang, Jian; Xie, Zijian

doi:10.1016/j.gene.2012.12.094

Cited by 26 publications

(22 citation statements)

References 24 publications

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“…The Met72 + genotype (GT or TT genotype, the protective genotypes of the present study) has been reported to be associated with the early onset of obesity in 3 studies [19][20][21]. However, it showed a protective effect against fat accumulation in a large population study of 3 cohorts [22] and type 2 diabetes in a recent meta-analysis [23]. According to a monozygotic twin study, the Met allele was more common among twin pairs with a low intra-pair BMI difference than those with a high intra-pair difference [24].…”

contrasting

confidence: 47%

Association Study of 60 Candidate Genes with Antipsychotic-induced Weight Gain in Schizophrenia Patients

et al. 2016

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contrasting

confidence: 47%

Association Study of 60 Candidate Genes with Antipsychotic-induced Weight Gain in Schizophrenia Patients

et al. 2016

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“…This may explain some publication bias in our meta-analysis, which may have affected the results of this meta-analysis in as far as those studies that had produced negative results might not have been published. Thirdly, type 2 diabetes is a complex disease which is affected by an interplay between many factors, including environmental exposure, life style, socioeconomic status and individual susceptibility [ 66 , 67 ]. It is possible that individual susceptibility in different ethnic groups may be modified by environmental exposure, life style and socioeconomic status in a different way.…”

Section: Discussionmentioning

confidence: 99%

Association between ADIPOQ +45T>G Polymorphism and Type 2 Diabetes: A Systematic Review and Meta-Analysis

Fan¹,

Wang²,

Xu³

et al. 2014

IJMS

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Recently, a number of studies have reported the association between the single nucleotide polymorphisms (SNPs) +45T>G polymorphism in the adiponectin (ADIPOQ) gene and type 2 diabetes mellitus (T2DM) risk, though the results are inconsistent. In order to obtain a more precise estimation of the relationship, a meta-analysis was performed. In this current study, the Medline, Embase, Pubmed, ISI Web of Knowledge, Ovid, Science Citation Index Expanded Database, Wanfang Database, and China National Knowledge Infrastructure were searched for eligible studies. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to estimate the strength of association. Forty-five publications were included in the final meta-analysis with 9986 T2DM patients and 16,222 controls for ADIPOQ +45T>G polymorphism according to our inclusion and exclusion criteria. The +45T>G polymorphism was associated with an overall significantly increased risk of T2DM (G vs. T: OR = 1.18, 95% CI = 1.06–1.32; The dominant model: OR = 1.18, 95% CI = 1.03–1.33; The recessive model: OR = 1.47, 95% CI = 1.20–1.78; The homozygous model: OR = 1.62, 95% CI = 1.25–2.09; Except the heterozygous model: OR = 1.11, 95% CI = 0.98–1.24). Subgroup analysis revealed a significant association between the +45T>G polymorphism and T2D in an Asian population. Thus, this meta-analysis indicates that the G allele of the ADIPOQ +45T>G polymorphisms associated with a significantly increased risk of T2DM in the Asian population.

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“…This SNP results in an amino acid substitution (leucine to methionine) at residue 72 which is outside the mature ghrelin product of 28 amino acids. Although its function is yet to be established, this polymorphism has been associated with several medical and psychiatric conditions, including diabetes (Liao et al, 2013), development of obesity (Miraglia del Giudice et al, 2004) and depression (Nakashima et al, 2008). However, its potential involvement in alcohol use disorders (AUD) is less clear.…”

Section: Introductionmentioning

confidence: 99%

The Leu72Met Polymorphism of the Prepro-ghrelin Gene is Associated With Alcohol Consumption and Subjective Responses to Alcohol: Preliminary Findings

Suchankova

Yan

Schwandt

et al. 2017

Alcohol and Alcoholism

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Aims: The orexigenic peptide ghrelin may enhance the incentive value of food-, drug-and alcoholrelated rewards. Consistent with preclinical findings, human studies indicate a role of ghrelin in alcohol use disorders (AUD). In the present study an a priori hypothesis-driven analysis was conducted to investigate whether a Leu72Met missense polymorphism (rs696217) in the prepro-ghrelin gene (GHRL), is associated with AUD, alcohol consumption and subjective responses to alcohol. Method: Association analysis was performed using the National Institute on Alcohol Abuse and Alcoholism (NIAAA) clinical sample, comprising AUD individuals and controls (N = 1127). Then, a post-hoc analysis using data from a human laboratory study of intravenous alcohol selfadministration (IV-ASA, N = 144) was performed to investigate the association of this SNP with subjective responses following a fixed dose of alcohol (priming phase) and alcohol selfadministration (ad libitum phase). Results: The case-control study revealed a trend association (N = 1127, OR = 0.665, CI = 0.44-1.01, P = 0.056) between AUD diagnosis and Leu72Met. In AUD subjects, the SNP was associated with significantly lower average drinks per day (n = 567, β = −2.49, 95% CI = −4.34 to −0.64, P = 0.008) and significantly fewer heavy drinking days (n = 567, β = −12.00, 95% CI = −19.10 to −4.89, P < 0.001). The IV-ASA study further revealed that 72Met carriers had greater subjective responses to alcohol (P < 0.05) when compared to Leu72Leu both at priming and during ad lib selfadministration.

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Association between the ghrelin Leu72Met polymorphism and type 2 diabetes risk: A meta-analysis

Cited by 26 publications

References 24 publications

Association Study of 60 Candidate Genes with Antipsychotic-induced Weight Gain in Schizophrenia Patients

Association Study of 60 Candidate Genes with Antipsychotic-induced Weight Gain in Schizophrenia Patients

Association between ADIPOQ +45T>G Polymorphism and Type 2 Diabetes: A Systematic Review and Meta-Analysis

The Leu72Met Polymorphism of the Prepro-ghrelin Gene is Associated With Alcohol Consumption and Subjective Responses to Alcohol: Preliminary Findings

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