Association Study of 60 Candidate Genes with Antipsychotic-induced Weight Gain in Schizophrenia Patients

Ryu, Seungho; Huh, Iksoo; Cho, E.-Y.; Cho, Y.; Park, Tansol; Yoon, Se Chang; Joo, Yeon Ho; Hong, Kyung Sue

doi:10.1055/s-0035-1569267

Cited by 9 publications

(16 citation statements)

References 25 publications

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“…There is also more evidence that supports the hypothesis that the "T" or Met72 allele of the GHRL rs696217 (Leu72Met) polymorphism has a protective effect on NAFLD. Met72Met subjects have lower values of BMI [43,44,45], fat mass [43], visceral fat [43], triglycerides [31], total cholesterol [46], HDL cholesterol [46], LDL cholesterol [46], insulin [31], IR [31], T2D [47], and a higher ghrelin level [31,48]. These findings are in agreement with ours.…”

Section: Discussionsupporting

confidence: 91%

The Leu72Met (rs696217 G>T) Polymorphism of the Ghrelin Gene Might Be a Protective Factor for Nonalcoholic Fatty Liver Disease

Tabaeian

Mahmoudi

Sabzikarian

et al. 2021

JGLD

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Background and Aims: Nonalcoholic fatty liver disease (NAFLD) is a growing problem and the commonest cause of chronic liver disease throughout the world. Given the strong association between NAFLD and insulin resistance and obesity, as well as the central role of ghrelin in these metabolic disorders, we explored whether ghrelin (GHRL) and ghrelin receptor (GHSR) gene polymorphisms were associated with susceptibility to NAFLD. Methods: In this case-control retrospective study which was conducted between April 2010 and July 2013, GHRL (rs696217 or Leu72Met) and GHSR (rs2922126) gene polymorphisms were genotyped in 153 cases with biopsy-proven NAFLD and 157 controls using the polymerase chain reaction - restriction fragment length polymorphism method. Results: The GHRL rs696217 “GT+TT” genotype or “GT” genotype compared with the “GG” genotype occurred less frequently in the patients with NAFLD than the controls and the differences remained significant after adjustment for confounding factors such as age and body mass index (p=0.018; OR=0.35, 95%CI: 0.14–0.84 and p=0.046; OR=0.40, 95%CI: 0.16–0.98, respectively). Furthermore, the GHRL rs696217 ‘T’ allele compared with ‘G’ allele was significantly underrepresented in the cases (p=0.007; OR=0.33, 95%CI: 0.15-0.76). Nevertheless, no significant difference was found for GHSR rs2922126 gene polymorphism. Conclusions: Our findings suggested, for the first time, that the GHRL rs696217 or Leu72Met “GT+TT” genotype and “GT” genotype compared with “GG” genotype, as well as the “T” or Met72 allele compared with “G” or Leu72 allele had a protective effect for NAFLD susceptibility. However, other studies are required to confirm these findings.

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Section: Discussionsupporting

confidence: 91%

The Leu72Met (rs696217 G>T) Polymorphism of the Ghrelin Gene Might Be a Protective Factor for Nonalcoholic Fatty Liver Disease

Tabaeian

Mahmoudi

Sabzikarian

et al. 2021

JGLD

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“…Studies were conducted across 12 countries in a range of settings. Four studies were from Korea, 30,31,34,35 three from the United Kingdom, 19,29,36 two from Spain 37,38 and one each from the United States, 12 Canada, 33 Ireland, 22 India, 39 Greece, 40 Turkey, 41 Israel 42 and France. 43 One study included a population from the United States and Canada 44 and one did not provide the country from which it was conducted.…”

Section: Resultsmentioning

confidence: 99%

Nutrition risk screening methods for adults living with severe mental illness: A scoping review

Hancox

Lee

Armaghanian

et al. 2021

Nutrition & Dietetics

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“…were significantly greater than those seen in homozygous GG carriers [83]. In a recent study, GHRL rs696217 was associated with both weight gain (P = 0.001) and appetite change (P = 0.042) in a Korean population treated with various antipsychotics [48]. As listed in the HapMap database, the rs696217-T frequency is 19.1% in the east Asian population, which is higher than the frequencies in the European (8.8%) and American (5.0%) populations.…”

Section: Ghrlmentioning

confidence: 91%

“…Although rs6313 was found to be in linkage disequilibrium with rs6311, Mou et al failed to demonstrate that rs6311 was associated with AIWG in first-episode SCZ patients [45]. In studies of other ethnicities, the results also remain inconsistent [46][47][48]. As listed in the HapMap project, the minor alleles of rs6313 and rs6311 differ between the Chinese and Caucasian populations, which may produce controversial pharmacogenetic results in different racial studies.…”

Section: Serotonin Receptormentioning

confidence: 99%

“…Pharmacogenetic studies in the Chinese population have many similarities and differences with those in other ethnicities. The candidate-gene approach has been widely used in Chinese studies as well as in studies of other ethnic groups [26,36,48,75]. The candidate genes are mainly antipsychotic affinity receptor-encoding genes (e.g., HTR2C, DRD2, ADRA1A, and HRH1), endocrine regulation-related genes (e.g., GHRL, ADIPOQ, and LEP), and neural development-related genes (e.g., BDNF and NRXN3).…”

Section: Conclusion and Future Perspectivementioning

confidence: 99%

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Pharmacogenetic Correlates of Antipsychotic-Induced Weight Gain in the Chinese Population

et al. 2019

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Antipsychotic-induced weight gain (AIWG) is a common adverse effect of this treatment, particularly with second-generation antipsychotics, and it is a major health problem around the world. We aimed to review the progress of pharmacogenetic studies on AIWG in the Chinese population to compare the results for Chinese with other ethnic populations, identify the limitations and problems of current studies, and provide future research directions in China. Both English and Chinese electronic databases were searched to identify eligible studies. We determined that [ 25 single-nucleotide polymorphisms in 19 genes have been investigated in association with AIWG in Chinese patients over the past few decades. HTR2C rs3813929 is the most frequently studied single-nucleotide polymorphism, and it seems to be the most strongly associated with AIWG in the Chinese population. However, many genes that have been reported to be associated with AIWG in other ethnic populations have not been included in Chinese studies. To explain the pharmacogenetic reasons for AIWG in the Chinese population, genome-wide association studies and multiple-center, standard, unified, and large samples are needed.

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Association Study of 60 Candidate Genes with Antipsychotic-induced Weight Gain in Schizophrenia Patients

Abstract: Our findings suggested the involvement of a GHRL polymorphism in weight gain, which was specifically mediated by appetite change, during antipsychotic treatment in schizophrenia patients.

Cited by 9 publications

References 25 publications

The Leu72Met (rs696217 G>T) Polymorphism of the Ghrelin Gene Might Be a Protective Factor for Nonalcoholic Fatty Liver Disease

The Leu72Met (rs696217 G>T) Polymorphism of the Ghrelin Gene Might Be a Protective Factor for Nonalcoholic Fatty Liver Disease

Nutrition risk screening methods for adults living with severe mental illness: A scoping review

Pharmacogenetic Correlates of Antipsychotic-Induced Weight Gain in the Chinese Population

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